1. Peripartum type B aortic dissection in patients with Marfan syndrome who underwent aortic root replacement: a case series study
- Author
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Yutaka Osuga, Masahiko Bougaki, Tomoyuki Fujii, Takayuki Iriyama, Takeshi Nagamatsu, Kan Nawata, Haruo Yamauchi, Sonoko Maemura, Atushi Komatsu, Toshio Nakayama, Ryo Inuzuka, Hironobu Hyodo, Rieko Shitara, Seisuke Sayama, Daishi Fujita, and Norifumi Takeda
- Subjects
Adult ,Marfan syndrome ,Pediatrics ,medicine.medical_specialty ,Pregnancy, High-Risk ,Pregnancy Complications, Cardiovascular ,Population ,Aortic Diseases ,030204 cardiovascular system & hematology ,Marfan Syndrome ,03 medical and health sciences ,Aortic aneurysm ,Postoperative Complications ,0302 clinical medicine ,Japan ,Pregnancy ,Peripartum Period ,medicine ,Humans ,education ,Retrospective Studies ,Aortic dissection ,education.field_of_study ,030219 obstetrics & reproductive medicine ,business.industry ,Incidence ,Incidence (epidemiology) ,Pregnancy Outcome ,Obstetrics and Gynecology ,medicine.disease ,Surgery ,Aortic Dissection ,Female ,Risk Adjustment ,business ,Vascular Surgical Procedures ,Case series - Abstract
OBJECTIVE To investigate pregnancy outcomes, especially the risk of pregnancy-related aortic dissection (AD), in patients with Marfan syndrome (MFS) after prophylactic aortic root replacement (ARR). DESIGN Retrospective case series study. SETTING Tertiary perinatal care centre at a university hospital. POPULATION Pregnant women fulfilling the revised Ghent nosology (2010) criteria for MFS who were managed at our institute. METHODS The pregnancy outcomes of all patients with MFS managed at our institute between 1982 and September 2016 were reviewed retrospectively based on medical records. MAIN OUTCOME MEASURES Obstetrical management and complication including the incidence of AD throughout the peripartum period. RESULTS Among 22 patients (28 pregnancies) who had been managed as potential MFS or related disorders, 14 (17 pregnancies) fulfilled the revised Ghent nosology (2010) criteria for MFS and were enrolled in this study. Five patients (five pregnancies) had received ARR before conception: three (60%) developed type B aortic dissection [AD(B)] during the peripartum period, compared with only one of 10 patients (12 pregnancies) without ARR (P
- Published
- 2017
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