Leighton, Samuel P., Krishnadas, Rajeev, Upthegrove, Rachel, Marwaha, Steven, Steyerberg, Ewout W., Gkoutos, Georgios V., Broome, Matthew R., Liddle, Peter F., Everard, Linda, Singh, Swaran P., Freemantle, Nicholas, Fowler, David, Jones, Peter B., Sharma, Vimal, Murray, Robin, Wykes, Til, Drake, Richard J., Buchan, Iain, Rogers, Simon, Cavanagh, Jonathan, Lewis, Shon W., Birchwood, Max, and Mallikarjun, Pavan K.
AimsPsychosis is a major mental illness with first onset in young adults. The prognosis is poor in around half of the people affected, and difficult to predict. The few tools available to predict prognosis have major weaknesses which limit their use in clinical practice. We aimed to develop and validate a risk prediction model of symptom non-remission in first-episode psychosis.MethodOur development cohort consisted of 1027 patients with first-episode psychosis recruited between 2005 to 2010 from 14 early intervention services across the National Health Service in England. Our validation cohort consisted of 399 patients with first-episode psychosis recruited between 2006 to 2009 from a further 11 English early intervention services. The one-year non-remission rate was 52% and 54% in the development and validation cohorts, respectively. Multivariable logistic regression was used to develop a risk prediction model for non-remission, which was externally validated.ResultThe prediction model showed good discrimination (C-statistic of 0.74 (0.72, 0.76) and adequate calibration with intercept alpha of 0.13 (0.03, 0.23) and slope beta of 0.99 (0.87, 1.12). Our model improved the net-benefit by 16% at a risk threshold of 50%, equivalent to 16 more detected non-remitted first-episode psychosis individuals per 100 without incorrectly classifying remitted cases.ConclusionOnce prospectively validated, our first episode psychosis prediction model could help identify patients at increased risk of non-remission at initial clinical contact.