1. Do men with mild erectile dysfunction have the same risk factors as the general erectile dysfunction clinical trial population?
- Author
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Lee, Jay C., Bénard, Francois, Carrier, Serge, Talwar, Varun, and Defoy, Isabelle
- Subjects
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MEN'S health , *CLINICAL trials , *RANDOMIZED controlled trials , *BLIND experiment , *HYPERCHOLESTEREMIA , *ETIOLOGY of diseases ,IMPOTENCE risk factors - Abstract
OBJECTIVE • To compare the underlying risk for diseases associated with erectile dysfunction (ED; i.e. cardiovascular disease and diabetes) in a population of men with mild ED relative to a general ED clinical trial population. PATIENTS AND METHODS • Men enrolled in a randomized, doubleblind placebo-controlled (DBPC) trial of sildenafil for the treatment of mild ED were compared with a database of men enrolled in 67 of the manufacturer’s other DBPC sildenafil trials. • The main outcome measures were baseline demographics, comorbidities and concomitant medications. RESULTS • In both populations, most men were white, approximately one quarter were smokers, and most had an organic component to their ED etiology. • In the mild ED population ( N = 176) versus the database population ( N = 14 537), mean ± SD (range) age was 50 ± 12 (19-84) versus 55 ± 11 (18–89) years, body mass index was 29 ± 5 (20–48) versus 28 ± 5 (11–64) kg/m² and ED duration was 3.5 ± 3.2 ( < 1–18) versus 4.6 ± 4.7 ( < 1–45) years. • The prevalence of comorbidities associated with ED was similar (hypertension 26.1% ( n = 46) vs 32.8%; diabetes mellitus 13.6% ( n = 24) vs 22.1%; dyslipidemias 12.5% ( n = 22) vs 11.7%; hypercholesterolemia 12.5% ( n= 22) vs 9.5%; gastro-esophageal reflux disease 10.8% ( n = 19) vs 6.0%; benign prostatic hyperplasia 9.7% ( n = 17) vs 9.9%; depression 6.3% ( n = 11) vs 5.6%; and anxiety 4.0% ( n = 7) vs 1.6%), as was the rate of use of medications for those comorbidities. CONCLUSIONS • Men with mild ED have similar risk factors to a general ED clinical trial population. Thus, mild ED is an important indicator of risk for underlying disease associated with ED. • Inquiry into ED should be part of routine clinical evaluation to facilitate rapid identification and early intervention. • Men complaining of mild ED should be evaluated adequately for underlying cardiovascular risk. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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