1. DaPeCa-1: diagnostic accuracy of sentinel lymph node biopsy in 222 patients with penile cancer at four tertiary referral centres - a national study from Denmark
- Author
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Peter Sommer, Birgitte Grønkær Toft, Vivi Bakholdt, Jens Ahm Sørensen, Jørgen Bjerggaard Jensen, Kasper Ørding Olsen, Kirsten Bouchelouche, Henrik Nerstrøm, Kim Predbjørn Krarup, Søren Høyer, Jakob Kristian Jakobsen, and Bjarne Kromann-Andersen
- Subjects
Male ,multicentre ,Denmark ,030232 urology & nephrology ,Tertiary Care Centers ,lymph node staging ,Neoplasm Recurrence, Local/diagnostic imaging ,0302 clinical medicine ,Interquartile range ,Lymph Nodes/diagnostic imaging ,medicine.diagnostic_test ,Middle Aged ,Sentinel node ,Dissection ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Penile Neoplasms/diagnostic imaging ,Carcinoma, Squamous Cell ,medicine.medical_specialty ,Urology ,Sentinel lymph node ,squamous cell carcinoma of the penis ,Malignancy ,Carcinoma, Squamous Cell/diagnostic imaging ,03 medical and health sciences ,Predictive Value of Tests ,Biopsy ,Sentinel Lymph Node Biopsy/methods ,medicine ,Humans ,Penile cancer ,Radionuclide Imaging ,Penile Neoplasms ,Aged ,Retrospective Studies ,Neoplasm Staging ,Groin ,Sentinel Lymph Node Biopsy ,business.industry ,penile cancer ,sensitivity ,medicine.disease ,Denmark/epidemiology ,Surgery ,sentinel node ,Lymph Node Excision ,Lymph Nodes ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Objectives To estimate the diagnostic accuracy of sentinel lymph node biopsy (SNB) in patients with penile cancer and assess SNB complications in a national multicentre setting. Patients and methods Retrospectively data were collected from records in four university centres by one medical doctor covering all SNBs performed in Denmark between 1 January 2000 and 31 December 2010. Patients had either impalpable lymph nodes (LNs) in one or both groins, or had a palpable inguinal mass from which aspiration cytology failed to reveal malignancy. Patients were injected with nanocolloid technetium and had a scintigram recorded before the SNB. The primary endpoint was LN recurrence on follow-up. The secondary endpoint was complications after SNB. Diagnostic accuracy was computed. Results In all, 409 groins in 222 patients were examined by SNB. The median (interquartile range) follow-up of patients who survived was 6.6 (5–10) years. Of 343 negative groins, eight were false negatives. The sensitivity was 89.2% (95% confidence interval 79.8–95.2%) per groin. Interestingly, four of 67 T1G1 patients had a positive SNB. In all, 28 of 222 (13%) patients had complications of Clavien-Dindo grade I–IIIa. Conclusion Penile cancer SNB with a close follow-up stages LN involvement reliably and has few complications in a national multicentre setting. Inguinal LN dissection was avoided in 76% of patients.
- Published
- 2015
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