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1. Hope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation (a national multicenter study)

Author

Jost, Edgar, Schmid, Christoph, Baurmann, Herrad, Blau, Igor, Holderried, Tobias, Hertenstein, Bernd, Hänel, Mathias, Bornhäuser, Martin, Neidlinger, Helga, Kobbe, Guido, Winkler, Julia, Schroeder, Thomas, Bug, Gesine, Hopfer, Olaf, Finke, Jürgen, Hasenkamp, Justin, Krüger, William, Müller, Lutz, Kröger, Nikolaus, Eder, Matthias, Luft, Thomas, Hilgendorf, Inken, Ringhoffer, Mark, Stölzel, Friedrich, Scheid, Christoph, Platzbecker, Uwe, Wortmann, Friederike, Heinicke, Thomas, Wagner, Eva, Klein, Stefan, Burchert, Andreas, Tischer, Johanna, Stelljes, Matthias, Schäfer-Eckart, Kerstin, Wolff, Daniel, Junghanss, Christian, Ritter, Markus, Kaufmann, Martin, Bethge, Wolfgang, Mytilineos, Joannis, Einsel, Hermann, Sockel, Katja, Neu, Annika, Goeckenjan, Maren, Ditschkowski, Markus, Kröger, Nicolaus, Ayuk, Francis A., Stoelzel, Friedrich, Middeke, Jan Moritz, Bertz, Hartmut, Beverungen, David, von Bonin, Malte, Egger-Heidrich, Katharina, Heberling, Lisa, Trautmann-Grill, Karolin, Teipel, Raphael, Fraccaroli, Alessia, Fante, Matthias, Scheid, Christof, Holtick, Udo, Blau, Igor Wolfgang, Wulf, Gerald, Schwerdtfeger, Rainer, Kaun, Stephan, Winter, Susann, Theuser, Catrin, Beyersmann, Jan, Bornhaeuser, Martin, Schmeller, Sandra, and Schetelig, Johannes

Published
2024
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2. Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

Author

Christen, Friederike, Hoyer, Kaja, Yoshida, Kenichi, Hou, Hsin-An, Waldhueter, Nils, Heuser, Michael, Hills, Robert K., Chan, Willy, Hablesreiter, Raphael, Blau, Olga, Ochi, Yotaro, Klement, Piroska, Chou, Wen-Chien, Blau, Igor-Wolfgang, Tang, Jih-Luh, Zemojtel, Tomasz, Shiraishi, Yuichi, Shiozawa, Yusuke, Thol, Felicitas, Ganser, Arnold, Löwenberg, Bob, Linch, David C., Bullinger, Lars, Valk, Peter J.M., Tien, Hwei-Fang, Gale, Rosemary E., Ogawa, Seishi, and Damm, Frederik

Published
2019
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3. Amsa/ARA-C Followed By TBI 4 Gy or High Dose Chemotherapy Conditioning Regimens in Primary Refractory AML - Significantly Worse Outcomes in Younger Patients Conditioned with 4 Gy TBI

Author

Al Hamed, Rama, Labopin, Myriam, Bethge, Wolfgang, Ganser, Arnold, Brecht, Arne, Tischer, Johanna, Kröger, Nicolaus, Bunjes, Donald, Einsele, Hermann, Verbeek, Mareike, Blau, Igor Wolfgang, Kaufmann, Martin, Brissot, Eolia, Bazarbachi, Ali, Schmid, Christoph, Spyridonidis, Alexandros, Nagler, Arnon, Ciceri, Fabio, and Mohty, Mohamad

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

4. Continuously Improving Outcome over Time after Second Allogeneic Stem Cell Transplantation in Relapsed Acute Myeloid Leukemia - a Retrospective Analysis of 1540 Patients on Behalf of the Acute Leukemia Working Party of EBMT

Author

Schmälter, Ann-Kristin, Ngoya, Maud, Finke, Jürgen, Kröger, Nicolaus, Stölzel, Friedrich, Stelljes, Matthias, Valerius, Thomas, Tischer, Johanna, Schröder, Thomas, Dreger, Peter, Blau, Igor Wolfgang, Savani, Bipin, Giebel, Sebastian, Esteve, Jordi, Bazarbachi, Ali, Nagler, Arnon, Schmid, Christoph, Ciceri, Fabio, and Mohty, Mohamad

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

5. Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

Author

Garg, Manoj, Nagata, Yasunobu, Kanojia, Deepika, Mayakonda, Anand, Yoshida, Kenichi, Haridas Keloth, Sreya, Zang, Zhi Jiang, Okuno, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Miyano, Satoru, Ding, Ling-Wen, Alpermann, Tamara, Sun, Qiao-Yang, Lin, De-Chen, Chien, Wenwen, Madan, Vikas, Liu, Li-Zhen, Tan, Kar-Tong, Sampath, Abhishek, Venkatesan, Subhashree, Inokuchi, Koiti, Wakita, Satoshi, Yamaguchi, Hiroki, Chng, Wee Joo, Kham, Shirley-Kow Yin, Yeoh, Allen Eng-Juh, Sanada, Masashi, Schiller, Joanna, Kreuzer, Karl-Anton, Kornblau, Steven M., Kantarjian, Hagop M., Haferlach, Torsten, Lill, Michael, Kuo, Ming-Chung, Shih, Lee-Yung, Blau, Igor-Wolfgang, Blau, Olga, Yang, Henry, Ogawa, Seishi, and Koeffler, H. Phillip

Published
2015
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6. Gvhd Prophylaxis Incorporating Methotrexate in Allo-HCT for Chronic Myeloid Malignancies and sAML: A Retrospective Analysis from the Cmwp of the EBMT

Author

Luft, Thomas, primary, Gras, Luuk, additional, Kostner, Linda, additional, Kröger, Nicolaus, additional, Schroeder, Thomas, additional, Platzbecker, Uwe, additional, Schetelig, Johannes, additional, Peffault de Latour, Régis, additional, Stelljes, Matthias, additional, Sengeloev, Henrik, additional, Ganser, Arnold, additional, Blau, Igor Wolfgang, additional, Dreger, Peter, additional, Yakoub-Agha, Ibrahim, additional, Maertens, Johan, additional, Salmenniemi, Urpu, additional, Bethge, Wolfgang, additional, Mielke, Stephan, additional, Kobbe, Guido, additional, Pouli, Anastasia, additional, de Wreede, Liesbeth C., additional, Raj, Kavita, additional, Drozd-Sokolowska, Joanna, additional, McLornan, Donal P., additional, and Robin, Marie, additional

Published
2022
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7. Registry Data Indicate a Meaningful Chance for Successful Pregnancies after Allogeneic Stem Cell Transplantation: Results from the German Stem Cell Transplant Registry (DRST)

Author

Sockel, Katja, primary, Frank, Sandra, additional, Neu, Annika, additional, Ditschkowski, Markus, additional, Hilgendorf, Inken, additional, Goeckenjan, Mareen, additional, Stoelzel, Friedrich, additional, Middeke, Jan Moritz, additional, Kröger, Nicolaus, additional, Ayuk, Francis A., additional, Eder, Matthias, additional, Bethge, Wolfgang, additional, Finke, Jürgen, additional, Bertz, Hartmut, additional, Kobbe, Guido, additional, Kaufmann, Martin, additional, Platzbecker, Uwe, additional, Beverungen, David, additional, Schmid, Christoph, additional, von Bonin, Malte, additional, Egger-Heidrich, Katharina, additional, Heberling, Lisa, additional, Trautmann-Grill, Karolin, additional, Teipel, Raphael, additional, Bug, Gesine, additional, Tischer, Johanna, additional, Fraccaroli, Alessia, additional, Holler, Barbara, additional, Wolff, Daniel, additional, Luft, Thomas, additional, Roesler, Wolf, additional, Schäfer-Eckart, Kerstin, additional, Dressler, Sabine, additional, Scheid, Christof, additional, Holtick, Udo, additional, Klein, Stefan, additional, Blau, Igor Wolfgang, additional, Burchert, Andreas, additional, Wulf, Gerald, additional, Hasenkamp, Justin, additional, Schwerdtfeger, Rainer, additional, Kaun, Stephan, additional, Wittke, Christoph, additional, Wortmann, Friederike, additional, Neidlinger, Helga, additional, Bornhaeuser, Martin, additional, Schetelig, Johannes, additional, and of the German Cooperative Transplant Study Group, on Behalf, additional

Published
2022
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8. Validation of the Transplant Conditioning Intensity (TCI) Score for Allogeneic Hematopoietic Cell Transplantation

Author

Spyridonidis, Alexandros, primary, Labopin, Myriam, additional, Gedde-Dahl, Tobias, additional, Ganser, Arnold, additional, Stelljes, Matthias, additional, Craddock, Charles, additional, Wagner, Eva Maria, additional, Versluis, Jurjen, additional, Schroeder, Thomas, additional, Blau, Igor Wolfgang, additional, Wulf, Gerald, additional, Dreger, Peter, additional, Olesen, Gitte, additional, Sengeloev, Henrik, additional, Kröger, Nicolaus, additional, Potter, Victoria, additional, Forcade, Edouard, additional, Passweg, Jakob, additional, Peffault de Latour, Régis, additional, Maertens, Johan, additional, Wilson, Keith, additional, Bourhis, Jean-Henri, additional, Savani, Bipin, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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10. Therapy-Related AML: Clinical/Biological Features and Long-Term Outcome in a Cohort of 1133 Adult AML Patients

Author

Gross, Sophia, primary, Ihlow, Jana, additional, Busack, Leonie, additional, Adamiak, Kacper, additional, Schrezenmeier, Jens F., additional, Jesse, Julia, additional, Schwarz, Michaela, additional, Floercken, Anne, additional, Rieger, Kathrin, additional, Krönke, Jan, additional, le Coutre, Philipp, additional, Boldt, Vivien, additional, von Bruenneck, Ann-Christin, additional, Horst, David, additional, Burmeister, Thomas, additional, Blau, Igor Wolfgang, additional, Keller, Ulrich, additional, Bullinger, Lars, additional, and Westermann, Joerg, additional

Published
2022
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11. Trends in the Use of Hematopoietic Stem Cell Transplantation in the Management of Relapsed/Refractory Diffuse Large B Cell Lymphoma. a Retrospective Analysis of the Lymphoma Working Party of the EBMT

Author

Sureda, Anna, primary, Boumendil, Ariane, additional, Berning, Philipp, additional, Finel, Hervé, additional, Caillot, Denis, additional, Roesler, Wolf, additional, Finke, Jürgen, additional, Blau, Igor Wolfgang, additional, Leblond, Veronique, additional, Bittenbring, Joerg, additional, Tsoulkani, Anna, additional, Carpenter, Ben, additional, Nagler, Arnon, additional, Blaise, Didier, additional, Dreger, Peter, additional, and Schmitz, Norbert, additional

Published
2022
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12. Implications and Prognostic Impact of Mass Spectrometry in Patients with Newly-Diagnosed Multiple Myeloma

Author

Mai, Elias K, primary, Huhn, Stefanie, additional, Miah, Kaya, additional, Poos, Alexandra M, additional, Scheid, Christof, additional, Weisel, Katja, additional, Bertsch, Uta, additional, Munder, Markus, additional, Berlanga, Oscar, additional, Hose, Dirk, additional, Seckinger, Anja, additional, Jauch, Anna, additional, Blau, Igor Wolfgang, additional, Haenel, Mathias, additional, Salwender, Hans, additional, Benner, Axel, additional, Raab, Marc S, additional, Goldschmidt, Hartmut, additional, and Weinhold, Niels, additional

Published
2022
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13. Single-Cell Clonal Tracking in Allogeneic Hematopoietic Stem Cell Transplantation Reveals Time Dependent and Distinct Functional Patterns in Traceable Donor T Cell Clones

Author

Wittenbecher, Friedrich, primary, Keilholz, Luisa, additional, Obermayer, Benedikt, additional, Conrad, Thomas, additional, Frentsch, Marco, additional, Blau, Igor Wolfgang, additional, Vuong, Lam Giang, additional, Borchert, Franziska, additional, Lesch, Stella, additional, Movasshagi, Kamran, additional, Tietze-Bürger, Carola, additional, Penack, Olaf, additional, Ahn, Johann, additional, Beule, Dieter, additional, Bullinger, Lars, additional, and Na, Il-Kang, additional

Published
2021
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14. Comparative Study of Unrelated and Haploidentical Donor Hematopoietic Cell Transplant for Chronic Myeloid Leukemia with Post Transplant Cyclophosphamide As Graft-Versus-Host Disease Prophylaxis: A Study from the Chronic Malignancies Working Party of EBMT

Author

Ortí, Guillermo, primary, Gras, Luuk, additional, Zinger, Nienke, additional, Kulagin, Aleksandr D., additional, Byrne, Jennifer, additional, Apperley, Jane F, additional, Halaburda, Kazimierz, additional, Blau, Igor Wolfgang, additional, Clark, Andrew, additional, Kröger, Nicolaus, additional, Griskevicius, Laimonas, additional, Carlson, Kristina, additional, Collin, Matthew P., additional, Bloor, Adrian, additional, Angelucci, Emanuele, additional, Blaise, Didier, additional, Aljurf, Mahmoud, additional, Lopez Corral, Lucia, additional, Anagnostopoulos, Achilles, additional, Beguin, Yves, additional, Wrobel, Tomasz, additional, Rigacci, Luigi, additional, Hayden, Patrick John, additional, Chalandon, Yves, additional, and Yakoub-Agha, Ibrahim, additional

Published
2021
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15. Allogeneic Stem Cell Transplantation in Patients Aged ≥70 Years: Epidemiology, Outcomes, and Risk Factors Based on the German Registry for Stem Cell Transplantation (DRST)

Author

Weller, Jan Frederic, primary, Kaufmann, Louisa, additional, Lengerke, Claudia, additional, Finke, Jürgen, additional, Schetelig, Johannes, additional, Platzbecker, Uwe, additional, Einsele, Hermann, additional, Beelen, Dietrich W., additional, Faul, Christoph, additional, Stelljes, Matthias, additional, Dreger, Peter, additional, Blau, Igor Wolfgang, additional, Wulf, Gerald, additional, Tischer, Johanna, additional, Scheid, Christof, additional, Elmaagacli, Ahmet, additional, Neidlinger, Helga, additional, Frank, Sandra, additional, Bornhäuser, Martin, additional, Bethge, Wolfgang A, additional, Fleischhauer, Katharina, additional, Kröger, Nicolaus, additional, and Christopeit, Maximilian, additional

Published
2021
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16. Prediction of Early Death and Severe Infections during Novel Agent-Based Induction Therapy in Newly-Diagnosed Multiple Myeloma: An Intergroup Analysis from the German Speaking Myeloma Multicenter Group, the Dutch-Belgian Cooperative Trial Group for Hematology Oncology Foundation and the European Myeloma Network

Author

Mai, Elias K, primary, Hielscher, Thomas, additional, Bertsch, Uta, additional, Salwender, Hans, additional, Zweegman, Sonja, additional, Munder, Markus, additional, Pantani, Lucia, additional, Brossart, Peter, additional, Beksac, Meral, additional, Blau, Igor Wolfgang, additional, Raab, Marc-Steffen, additional, Dürig, Jan, additional, Giesen, Nicola, additional, Besemer, Britta, additional, Fenk, Roland, additional, Reimer, Peter, additional, van der Holt, Bronno, additional, Haenel, Mathias, additional, Metzler, Ivana v., additional, Graeven, Ullrich, additional, Boccadoro, Mario, additional, Scheid, Christof, additional, Dimopoulos, Meletios A., additional, Weisel, Katja, additional, Cavo, Michele, additional, Sonneveld, Pieter, additional, and Goldschmidt, Hartmut, additional

Published
2021
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17. Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia with Hyperdiploid Complex Karyotype: A Study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Poiré, Xavier, primary, Labopin, Myriam, additional, Polge, Emmanuelle, additional, Ganser, Arnold, additional, Socie, Gerard, additional, Gedde-Dahl, Tobias, additional, Forcade, Edouard, additional, Finke, Jürgen, additional, Chalandon, Yves, additional, Bulabois, Claude-Eric, additional, Yakoub-Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Kröger, Nicolaus, additional, Blau, Igor Wolfgang, additional, Nagler, Arnon, additional, Esteve, Jordi, additional, and Mohty, Mohamad, additional

Published
2021
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18. Elotuzumab in Combination with Lenalidomide, Bortezomib, Dexamethasone and Autologous Transplantation for Newly-Diagnosed Multiple Myeloma: Results from the Randomized Phase III GMMG-HD6 Trial

Author

Goldschmidt, Hartmut, primary, Mai, Elias K, additional, Bertsch, Uta, additional, Besemer, Britta, additional, Haenel, Mathias, additional, Miah, Kaya, additional, Fenk, Roland, additional, Schlenzka, Jana, additional, Munder, Markus, additional, Dürig, Jan, additional, Blau, Igor Wolfgang, additional, Huhn, Stefanie, additional, Hose, Dirk, additional, Jauch, Anna, additional, Kunz, Christina, additional, Neubauer, Andreas, additional, Scheid, Christof, additional, Schroers, Roland, additional, Metzler, Ivana v., additional, Schieferdecker, Aneta, additional, Thomalla, Joerg, additional, Reimer, Peter, additional, Mahlberg, Rolf, additional, Graeven, Ullrich, additional, Kremers, Stephan, additional, Martens, Uwe M., additional, Kunz, Christian, additional, Hensel, Manfred, additional, Seidel-Glaetzer, Andrea, additional, Weisel, Katja, additional, Raab, Marc-Steffen, additional, and Salwender, Hans, additional

Published
2021
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19. Retrospective Comparison between 12-Gray and 8-Gray Total Body Irradiation (TBI) before Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Lymphoblastic Leukemia in First Complete Remission

Author

Spyridonidis, Alexandros, primary, Labopin, Myriam, additional, Savani, Bipin B., additional, Giebel, Sebastian, additional, Schmid, Christoph, additional, Peric, Zinaida, additional, Bug, Gesine, additional, Schönland, Stefan, additional, Kröger, Nicolaus, additional, Stelljes, Matthias, additional, Schroeder, Thomas, additional, McDonald, Andrew, additional, Blau, Igor Wolfgang, additional, Bornhäuser, Martin, additional, Rovira, Montserrat, additional, Bethge, Wolfgang, additional, Neubauer, Andreas, additional, Ganser, Arnold, additional, Bourhis, Jean-Henri, additional, Edinger, Matthias, additional, Lioure, Bruno, additional, Wulf, Gerald, additional, Schaefer-Eckart, Kerstin, additional, Arat, Mutlu, additional, Bazarbachi, Ali, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2021
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20. Two-Year Landmark Survival Analysis after Allogeneic Hematopoietic Cell Transplantation in Acute Lymphoblastic Leukemia: An Analysis from the ALWP of the EBMT

Author

Patel, Vivek, primary, Labopin, Myriam, additional, Schroeder, Thomas, additional, Blau, Igor Wolfgang, additional, Gjaerde, Lars Klingen, additional, Aljurf, Mahmoud, additional, Socié, Gérard, additional, Salmenniemi, Urpu, additional, Bethge, Wolfgang A, additional, Passweg, Jakob, additional, Balsat, Marie, additional, Nicholson, Emma, additional, Tischer, Johanna, additional, Giebel, Sebastian, additional, Peric, Zinaida, additional, Brissot, Eolia, additional, Dholaria, Bhagirathbhai, additional, Savani, Bipin B., additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2021
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23. Patterns of Renal Recovery and Toxicity with Novel Agent-Based Induction Triplets in Newly Diagnosed Multiple Myeloma - an Analysis of Two Prospective Studies By the German DSMM Myeloma Study Group

Author

Bachmann, Friederike, primary, Held, Swantje, additional, Engelhardt, Monika, additional, Langer, Christian, additional, Wolleschak, Denise, additional, Fleissner, Janik, additional, Mügge, Lars-Olof, additional, Duerk, Heinz, additional, Schreder, Martin, additional, Schaefer-Eckart, Kerstin, additional, Blau, Igor-Wolfgang, additional, Gramatzki, Martin, additional, Liebisch, Peter, additional, Reichle, Albrecht, additional, Metzler, Ivana, additional, Bassermann, Florian, additional, Metzner, Bernd, additional, Röllig, Christoph, additional, Hertenstein, Bernd, additional, Dechow, Tobias, additional, Jung, Wolfram, additional, Ostermann, Helmut, additional, Hebart, Holger, additional, Maschmeyer, Georg, additional, Salwender, Hans Jürgen, additional, von Lilienfeld-Toal, Marie, additional, Eckardt, Kai-Uwe, additional, Straka, Christian, additional, Einsele, Hermann, additional, and Knop, Stefan, additional

Published
2019
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24. Treatment Response and Long-Term Survival in Multiple Myeloma in the GMMG-HD4 Trial - Neither Profit All Molecular Entities Alike, Nor Are Remissions to Different Regimen Equal

Author

Seckinger, Anja, primary, Salwender, Hans Jürgen, additional, Martin, Hans, additional, Scheid, Christof, additional, Hielscher, Thomas, additional, Bertsch, Uta, additional, Hummel, Manuela, additional, Jauch, Anna, additional, Knauf, Wolfgang, additional, Emde, Martina, additional, Beck, Susanne, additional, Neben, Kai, additional, Lokhorst, Henk M., additional, van der Holt, Bronno, additional, Duehrsen, Ulrich, additional, Dürig, Jan, additional, Lindemann, Hans-Walter, additional, Schmidt-Wolf, Ingo, additional, Haenel, Mathias, additional, Lathan, Bernd, additional, Raab, Marc S, additional, Müller-Tidow, Carsten, additional, Sonneveld, Pieter, additional, Blau, Igor Wolfgang, additional, Hillengass, Jens, additional, Weisel, Katja, additional, Goldschmidt, Hartmut, additional, and Hose, Dirk, additional

Published
2018
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27. Lenalidomide, Adriamycin and Dexamethasone (RAD) Versus Bortezomib, Lenalidomide and Dexamethasone (VRD) in Newly Diagnosed Multiple Myeloma (MM) - Post-Induction Response and MRD Results By Flow Cytometry and NGS from a Phase 3 Randomized Controlled Clinical Trial (RCT)

Author

Stübig, Thomas, primary, Langer, Christian, additional, Engelhardt, Monika, additional, Mügge, Lars-Olof, additional, Bassermann, Florian, additional, Schreder, Martin, additional, Schäfer-Eckart, Kerstin, additional, Blau, Igor Wolfgang, additional, Wolleschak, Denise, additional, Reichle, Albrecht, additional, Metzler, Ivana, additional, Metzner, Bernd, additional, Rollig, Christoph, additional, Hertenstein, Bernd, additional, Dürk, Heinz, additional, Biersack, Harald, additional, Menzel, Helge, additional, Dechow, Tobias, additional, Schleicher, Jan, additional, Gramatzki, Martin, additional, Brümmendorf, Tim H., additional, Fuhrmann, Stephan, additional, Bittrich, Max, additional, Appelt, Franziska, additional, Müller, Martina, additional, Krönke, Jan, additional, Reusch, Julia, additional, Schmidt, Christian, additional, Brüggemann, Monika, additional, Held, Swantje, additional, Knop, Stefan, additional, and Einsele, Hermann, additional

Published
2018
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29. Hope for Motherhood: Pregnancy After Allogeneic Hematopoietic Cell Transplantation – a National Multicenter Study

Author

Sockel, Katja, Neu, Annika, Goeckenjan, Maren, Ditschkowski, Markus, Hilgendorf, Inken, Kröger, Nicolaus, Ayuk, Francis A., Stoelzel, Friedrich, Middeke, Jan Moritz, Eder, Matthias, Bethge, Wolfgang, Finke, Jürgen, Bertz, Hartmut, Kobbe, Guido, Kaufmann, Martin, Platzbecker, Uwe, Beverungen, David, Schmid, Christoph, von Bonin, Malte, Egger-Heidrich, Katharina, Heberling, Lisa, Trautmann-Grill, Karolin, Teipel, Raphael, Bug, Gesine, Tischer, Johanna, Fraccaroli, Alessia, Fante, Matthias, Wolff, Daniel, Luft, Thomas, Winkler, Julia, Schäfer-Eckart, Kerstin, Scheid, Christof, Holtick, Udo, Klein, Stefan, Blau, Igor Wolfgang, Burchert, Andreas, Wulf, Gerald, Hasenkamp, Justin, Schwerdtfeger, Rainer, Kaun, Stephan, Junghanss, Christian, Wortmann, Friederike, Winter, Susann, Neidlinger, Helga, Theuser, Catrin, Beyersmann, Jan, Bornhaeuser, Martin, Schmeller, Sandra, Schetelig, Johannes, Jost, Edgar, Schmid, Christoph, Baurmann, Herrad, Blau, Igor, Holderried, Tobias, Hertenstein, Bernd, Hänel, Mathias, Bornhäuser, Martin, Neidlinger, Helga, Kobbe, Guido, Winkler, Julia, Schroeder, Thomas, Bug, Gesine, Hopfer, Olaf, Finke, Jürgen, Hasenkamp, Justin, Krüger, William, Müller, Lutz, Kröger, Nikolaus, Eder, Matthias, Luft, Thomas, Hilgendorf, Inken, Ringhoffer, Mark, Stölzel, Friedrich, Scheid, Christoph, Platzbecker, Uwe, Wortmann, Friederike, Heinicke, Thomas, Wagner, Eva, Klein, Stefan, Burchert, Andreas, Tischer, Johanna, Stelljes, Matthias, Schäfer-Eckart, Kerstin, Wolff, Daniel, Junghanss, Christian, Ritter, Markus, Kaufmann, Martin, Bethge, Wolfgang, Mytilineos, Joannis, and Einsel, Hermann

Abstract

•Successful pregnancies are possible among female alloHCT recipients, although birth rate is more than six times lower than in the general population.•Key factors increasing the chance of motherhood were younger age at HCT, non-malignant disease, no TBI or dose <8Gy and RIC/NMA conditioning

Published
2024
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31. DNMT3A Mutations in AML Patients: Prognostic Impact and Comparative Analysis of Mutations Burden in Diagnostic Samples, after Standard Therapy, and after Allogeneic Stem Cell Transplantation

Author

Blau, Olga, primary, Behrenbeck, Franziska, additional, Suckert, Nikola, additional, Fransecky, Lars R., additional, Baldus, Claudia D., additional, Arnold, Renate, additional, Pezzutto, Antonio, additional, Dörken, Bernd, additional, and Blau, Igor Wolfgang, additional

Published
2016
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32. Evaluation of Stem Cell Mobilization in Patients with Multiple Myeloma after Lenalidomide-Based Induction Chemotherapy within the GMMG-HD6 Trial

Author

Wuchter, Patrick, primary, Bertsch, Uta, additional, Salwender, Hans-Juergen, additional, Munder, Markus, additional, Haenel, Mathias, additional, Benner, Axel, additional, Becker, Natalia, additional, Fenk, Roland, additional, Duerig, Jan, additional, Blau, Igor Wolfgang, additional, Lisenko, Katharina, additional, Hillengass, Jens, additional, Raab, Marc S., additional, Baertsch, Marc Andrea, additional, Seidel-Glaetzer, Andrea, additional, Ho, Anthony D, additional, Graeven, Ullrich, additional, Scheid, Christof, additional, Weisel, Katja, additional, and Goldschmidt, Hartmut, additional

Published
2016
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33. Immunological Subgroups Predicting Efficacy of Elotuzumab in Multiple Myeloma Patients: Insights from the GMMG-HD6 Clinical Trial

Author

Ton, Gigi Nu Hoang Quy, Kriegsmann, Katharina, Awwad, Mohamed H.S., Benner, Axel, Bertsch, Uta, Besemer, Britta, Hänel, Mathias, Fenk, Roland, Schlenzka, Jana, Munder, Markus, Dürig, Jan, Blau, Igor Wolfgang, Huhn, Stefanie, Hose, Dirk, Jauch, Anna, Neubauer, Andreas, Weinhold, Niels, Scheid, Christof, Schroers, Roland, von Metzler, Ivana, Schieferdecker, Aneta, Thomalla, Jörg, Reimer, Peter, Mahlberg, Rolf, Graeven, Ullrich, Kremers, Stephan, Martens, Uwe, Kunz, Christian, Hensel, Manfred, Seidel-Glätzer, Andrea, Weisel, Katja, Salwender, Hans, Müller-Tidow, Carsten, Raab, Marc S., Goldschmidt, Hartmut, Mai, Elias K., and Hundemer, Michael

Abstract

Introduction: Elotuzumab, a monoclonal antibody targeting SLAM family member 7 protein (SLAMF7) on multiple myeloma (MM) cells, has shown promise in relapsed/refractory MM when combined with immunomodulatory agents. However, its effectiveness in newly diagnosed patients did not show improved progression-free survival (PFS) nor overall survival. In a previous study we demonstrated that elotuzumab specifically depleted high SLAMF7 expressing regulatory CD8 +T cells by macrophage induced antibody dependent phagocytosis. This study aimed to identify immunological predictive factors for elotuzumab efficacy, enabling improved risk stratification and personalized treatment decisions based on the detection and quantification of SLAMF7-positive T cell subsets.

Published
2023
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36. A Predictive Score for Early Mortality during Induction Therapy in Newly Diagnosed Transplant-Eligible Multiple Myeloma - an Analysis from Five GMMG and HOVON Multicenter Phase III Trials

Author

Mai, Elias K, Hielscher, Thomas, Bertsch, Uta, Schlenzka, Jana, Salwender, Hans Jürgen, Lokhorst, Henk M, Munder, Markus, van der Holt, Bronno, Gerecke, Christian, Pfreundschuh, Michael, Duhrsen, Ulrich, Brossart, Peter, Zweegman, Sonja, Neben, Kai, Hillengass, Jens, Raab, Marc-Steffen S, Hose, Dirk, Vellenga, Edo, Merz, Maximilian, Breitkreutz, Iris, Jauch, Anna, Kersten, Marie José, Martin, Hans, Lindemann, Hans-Walter, Peter, Norma, Croockewit, Sandra, Blau, Igor Wolfgang, Scheid, Christof, Weisel, Katja C., Sonneveld, Pieter, and Goldschmidt, Hartmut

Published
2017
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37. Direct Assessment of IgA and IgG Paraprotein By Hevylite Assay and Correlation to IMWG Response and Progression-Free Survival in Newly Diagnosed, Transplant-Eligible Multiple Myeloma Patients in the Prospective Phase III GMMG-MM5 Trial

Author

Scheid, Christof, Seckinger, Anja, Dürig, Jan, Weisel, Katja C., Kunz, Christina, Bertsch, Uta, Hielscher, Thomas, Munder, Markus, Lindemann, Hans-Walter, Huegle-Doerr, Barbara, Huhn, Stefanie, Mai, Elias K, Jauch, Anna, Rabold, Bernhard, Gerecke, Christian, Brossart, Peter, Goerner, Martin, Bernhard, Helga, Hoffmann, Martin, Hillengass, Jens, Raab, Marc-Steffen S, Blau, Igor Wolfgang, Haenel, Mathias, Hose, Dirk, Goldschmidt, Hartmut, and Salwender, Hans Jürgen

Published
2017
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38. Response-Adapted Lenalidomide Maintenance in Newly Diagnosed, Transplant-Eligible Multiple Myeloma: Results from the Multicenter Phase III GMMG-MM5 Trial

Author

Goldschmidt, Hartmut, Mai, Elias K, Dürig, Jan, Scheid, Christof, Weisel, Katja C., Kunz, Christina, Bertsch, Uta, Hielscher, Thomas, Munder, Markus, Lindemann, Hans-Walter, Huegle-Doerr, Barbara, Hose, Dirk, Seckinger, Anja, Huhn, Stefanie, Jauch, Anna, Rabold, Bernhard, Elmaagacli, Ahmet, Gerecke, Christian, Brossart, Peter, Goerner, Martin, Bernhard, Helga, Hoffmann, Martin, Hillengass, Jens, Raab, Marc-Steffen S, Blau, Igor Wolfgang, Hänel, Mathias, and Salwender, Hans Jürgen

Published
2017
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39. Results from the 208-Week (4-Year) Follow-up of RESPONSE Trial, a Phase 3 Study Comparing Ruxolitinib (Rux) with Best Available Therapy (BAT) for the Treatment of Polycythemia Vera (PV)

Author

Kiladjian, Jean-Jacques, Verstovsek, Srdan, Griesshammer, Martin, Masszi, Tamás, Durrant, Simon, Passamonti, Francesco, Harrison, Claire N., Pane, Fabrizio, Zachee, Pierre, Kirito, Keita, Besses, Carlos, Hino, Masayuki, Varela, Ana Ines, Miller, Carole B., Rumi, Elisa, Rosti, Vittorio, Blau, Igor Wolfgang, Mesa, Ruben A, Dong, Tuochuan, Francillard, Nathalie, Laughlin, Mary, and Vannucchi, Alessandro M.

Published
2017
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42. Treosulfan Based Conditioning Prior To Allogeneic Stem Cell Transplantation (HSCT) For Acute Myelogenous Leukemia (AML): A Retrospective Analysis From The ALWP Of The EBMT

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Shimoni, Avichai, additional, Beelen, Dietrich, additional, Kyrcz-Krzemien, Slawomira, additional, Schufer-Eckart, Kerstin, additional, Volin, Liisa, additional, Hallek, Michael, additional, Griskevicius, Laimonas, additional, Blau, Igor-Wolfgang, additional, Casper, Jochen, additional, Ciceri, Fabio, additional, and Mohty, Mohamad, additional

Published
2013
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43. Prognostic Value Of sFLC Ratio At Baseline On Response After Induction Therapy In Patients With Multiple Myeloma In The GMMG MM5 Trial

Author

Moohialdin, Mabast, primary, Salwender, Hans, additional, Bertsch, Uta, additional, Duerig, Jan, additional, Kunz, Christina, additional, Hielscher, Thomas, additional, Zorn, Markus, additional, Haenel, Mathias, additional, Blau, Igor Wolfgang, additional, Hose, Dirk, additional, Schurich, Baerbel, additional, Neben, Kai, additional, Seckinger, Anja, additional, Munder, Markus, additional, Lindemann, Walter, additional, Zeis, Matthias, additional, Gerecke, Christian, additional, Schmidt-Wolf, Ingo GH, additional, Weisel, Katja, additional, Scheid, Christof, additional, and Goldschmidt, Hartmut, additional

Published
2013
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44. GMMG MM5 Trial In Newly Diagnosed Multiple Myeloma To Evaluate PAd Vs VCD Induction Prior To High Dose Treatment Followed By Lenalidomide Consolidation and Maintenance – Final Analysis On Induction Therapy

Author

Goldschmidt, Hartmut, primary, Duerig, Jan, additional, Bertsch, Uta, additional, Kunz, Christina, additional, Hielscher, Thomas, additional, Haenel, Mathias, additional, Blau, Igor Wolfgang, additional, Hose, Dirk, additional, Jauch, Anna, additional, Schurich, Baerbel, additional, Neben, Kai, additional, Seckinger, Anja, additional, Huegle-Doerr, Barbara, additional, Merz, Maximilian, additional, Munder, Markus, additional, Lindemann, Walter, additional, Zeis, Matthias, additional, Gerecke, Christian, additional, Schmidt-Wolf, Ingo GH, additional, Weisel, Katja, additional, Scheid, Christof, additional, and Salwender, Hans, additional

Published
2013
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45. Aberrant Expression Of miRNA and mRNA Of Cell Cycle and Adhesion-Related Genes In Bone Marrow Stroma Cells Derived From Patients With Multiple Myeloma

Author

Antonio Pezzutto, Bernd Dörken, Marlies Wächter, Olga Blau, Rimma Berenstein, Axel Nogai, and Blau Igor Wolfgang

Subjects
Angiogenesis, Immunology, Cell Biology, Hematology, Biology, Cell cycle, medicine.disease, Biochemistry, Molecular biology, medicine.anatomical_structure, Downregulation and upregulation, Cell culture, Gene expression, medicine, CDKN1B, Bone marrow, Multiple myeloma
Abstract

Multiple myeloma (MM) is a B-cell malignancy characterized by accumulation of malignant plasma cells (PC) within the bone marrow. The bone marrow microenvironment such as bone marrow stroma cells (BMSC) supports MM disease progression, resistance to chemotherapy, protects the tumor cells against apoptosis and causes osteolytic bone disease and angiogenesis. The aim of this study was to identify constitutive genetic alterations in BMSC derived from patients with MM (MM-BMSC) in comparison to BMSC from healthy donors. For BMSC selection, mononuclear cells were isolated from fresh bone marrow aspirates and were further expanded in cell culture. We studied 25 MM patients and 5 healthy donors. Senescence status was determined in passage 1 of cell cultures. MM-BSMC displayed a considerably higher percentage of senescence cells (p A downregulation of CCNE1 (p=0,05), CDKN1B (p=0,29), and an upregulation of CCND1 (p=0,05), VCAM-1 (p=0,33), ICAM-1 (p=0,33), and IKK-alpha (p=0,05) was demonstrated. Furthermore, the expression profile of miRNAs, targeting the analyzed mRNA genes or correlating with senescence, was studied (miR-16, miR-221, miR-126, miR-223, miR-485-5p and miR-519d). For miRNA detection treatment with Poly(A)-Polymerase and cDNA-Synthesis with a Poly(T)VN-Adaptor primer were carried out following an amplification with an universal reverse primer corresponding to the adaptor sequence and a miRNA-specific primer. miR-16, miR-223, miR-485-5p and miR-519d were significantly upregulated, (p=0,02; p=0,004; p=0,02; and p=0,002, respectively), whereas miR-221 and miR-126 showed no considerable differences to BMSC obtained from healthy donors. Next we investigated incubation of immunmodulatory drug Lenalidomid in BMSC cultures. Cells were treated with 10 µM Lenalidomid over 72 hours and expression was normalized to a 0,01 % DMSO control. Significant difference in gene expression were visible for ICAM-1 (p=0,01). For CDKN1B (p=0,16) and VCAM-1 (p=0,12) we demonstrated changes in gene expression. Our results indicate aberrant expression of cell cycle and adhesion-related genes, such as CCNE1, CCND1 and CDKN1B VCAM-1, ICAM-1 and IKK-alpha in MM-BMSC as compared with healthy donors. Furthermore, we found significant upregulation of miR-16, miR-223, miR-485-5p and miR-519d. Further investigation are needed to determine molecular mechanisms in MM-BMSC and PC interaction that lead to constitutive changes in BMSC characteristics and gene expression patterns. Disclosures: No relevant conflicts of interest to declare.

Published
2013

46. Prognostic Impact of Recipient and Donor CMV Serostatus in Acute Leukemia Patients After Allogeneic Stem Cell Transplantation At the Era of Preemptive Therapy.

Author

Schmidt-Hieber, Martin, primary, Labopin, Myriam, additional, Beelen, Dietrich, additional, Volin, Liisa, additional, Ehninger, Gerhard, additional, Finke, Jürgen, additional, Socie, Gerard, additional, Schwerdtfeger, Rainer, additional, Kröger, Nicolaus, additional, Ganser, Arnold, additional, Niederwieser, Dietger, additional, Feldmann, Ulrike, additional, Müller, Carlheinz, additional, Polge, Emanuelle, additional, Blau, Igor Wolfgang, additional, and Mohty, Mohamad, additional

Published
2012
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48. A Phase II Study of Elacytarabine/Idarubicin As Second Course Remission-Induction in Patients with Acute Myeloid Leukemia Who Failed Cytarabine/Anthracycline, and Evaluation of the Impact of the Nucleoside Transporter hENT1 on Response

Author

Rizzieri, David A., primary, Vey, Norbert, additional, Schlenk, Richard F., additional, Thomas, Xavier, additional, Huguet, Françoise, additional, Gjertsen, Bjorn, additional, Krauter, Jürgen, additional, Blau, Igor Wolfgang, additional, Johansen, Malin, additional, Gianelli-Borradori, Athos, additional, Jacobsen, Tove Flem, additional, Rao, Jianyu, additional, and Krug, Utz, additional

Published
2011
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50. Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts

Author

Blau, Olga, primary, Baldus, Claudia Dorothea, additional, Hofmann, Wolf-Karsten, additional, Thiel, Gundula, additional, Nolte, Florian, additional, Burmeister, Thomas, additional, Türkmen, Seval, additional, Benlasfer, Ouidad, additional, Schümann, Elke, additional, Sindram, Annette, additional, Molkentin, Mara, additional, Mundlos, Stefan, additional, Keilholz, Ulrich, additional, Thiel, Eckhard, additional, and Blau, Igor Wolfgang, additional

Published
2011
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