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10 results on '"Brady, Michael"'

1. Indolent Lymphoma and Vitamin D (ILyAD): A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Supplemental Effect of Vitamin D on Event-Free Survival in Patients with Low Tumor Burden Indolent Non-Hodgkin Lymphoma Treated with Rituximab

Author

Friedberg, Jonathan W., primary, Brady, Michael T., additional, Strawderman, Myla, additional, Kahl, Brad S., additional, Leonard, John P., additional, Lossos, Izidore S., additional, Flowers, Christopher R., additional, Sutamtewagul, Grerk, additional, Cohen, Jonathon B., additional, Peterson, Derick R., additional, and Nastoupil, Loretta J., additional

Published
2019
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2. Ilyad: A Phase III Double Blind, Randomized Trial Evaluating Vitamin D (Cholecalciferol) in Patients with Low Tumor-Burden Indolent Non-Hodgkin Lymphoma Treated with Rituximab Therapy

Author

Friedberg, Jonathan W., Brady, Michael T., Myla, Strawderman, Kahl, Brad S., Lossos, Izidore S., Cohen, Jonathon B., Reagan, Patrick M., Casulo, Carla, Averill, Barbara L., Link, Brian K., Barr, Paul M., Leonard, John P., Ashton, John M., Peterson, Derick R, and Nastoupil, Loretta J.

Abstract

Background: We and others have reported a significant association between low vitamin D levels at diagnosis of indolent B-cell lymphomas and inferior overall survival; the magnitude of this association is stronger than conventional clinical prognostic features. Vitamin D insufficiency impairs rituximab-mediated cytotoxicity and impairs macrophage function, which impacts rituximab responses in vivo. We therefore conducted a phase III, double-bind study of oral cholecalciferol vs. placebo for three years in patients with indolent lymphoma treated with rituximab monotherapy.

Published
2023
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5. Follicular lymphoma tumor–infiltrating T-helper (TH) cells have the same polyfunctional potential as normal nodal TH cells despite skewed differentiation

Author

Hilchey, Shannon P., primary, Rosenberg, Alexander F., additional, Hyrien, Ollivier, additional, Secor-Socha, Shelley, additional, Cochran, Matthew R., additional, Brady, Michael T., additional, Wang, Jyh-Chiang E., additional, Sanz, Iñaki, additional, Burack, W. Richard, additional, Quataert, Sally A., additional, and Bernstein, Steven H., additional

Published
2011
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9. Follicular lymphoma tumor–infiltrating T-helper (TH) cells have the same polyfunctional potential as normal nodal THcells despite skewed differentiation

Author

Hilchey, Shannon P., Rosenberg, Alexander F., Hyrien, Ollivier, Secor-Socha, Shelley, Cochran, Matthew R., Brady, Michael T., Wang, Jyh-Chiang E., Sanz, Iñaki, Burack, W. Richard, Quataert, Sally A., and Bernstein, Steven H.

Abstract

The follicular lymphoma (FL) T-cell microenvironment plays a critical role in the biology of this disease. We therefore determined the lineage, differentiation state, and functional potential of FL-infiltrating CD4+T-helper cells (TH) compared with reactive and normal lymph node (NLN) THcells. Relative to NLNs, FL cells have decreased proportions of naive and central memory but increased proportions of effector memory THcells. We further show differences in the distribution and anatomical localization of CXCR5+THpopulations that, on the basis of transcription factor analysis, include both regulatory and follicular helper T cells. On Staphylococcusenterotoxin-B stimulation, which stimulates T cells through the T-cell receptor, requires no processing by APCs, and can overcome regulator T cell-mediated suppression, the proportion of uncommitted primed precursor cells, as well as TH2 and TH17 cells is higher in FL cells than in reactive lymph nodes or NLNs. However, the proportion of TH1 and polyfunctional THcells (producing multiple cytokines simultaneously) is similar in FL cells and NLNs. These data suggest that, although TH-cell differentiation in FL is skewed compared with NLNs, FL THcells should have the same intrinsic ability to elicit antitumor effector responses as NLN THcells when tumor suppressive mechanisms are attenuated.

Published
2011
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10. Follicular lymphoma tumor-infiltrating T-helper (TH) cells have the same polyfunctional potential as normal nodal TH cells despite skewed differentiation.

Author

Hilchey, Shannon P., Rosenberg, Alexander F., Hyrien, Ollivier, Secor-Socha, Shelley, Cochran, Matthew R., Brady, Michael T., Wang, Jyh-Chiang E., Sanz, Iñaki, Burack, W. Richard, Quataert, Sally A., and Bernstein, Steven H.

Subjects
*T cells, *FACTOR analysis, *TRANSCRIPTION factors, *LYMPH nodes, *TUMORS, *STAPHYLOCOCCUS
Abstract

The follicular lymphoma (FL) T-cell microenvironment plays a critical role in the biology of this disease. We therefore determined the lineage, differentiation state, and functional potential of FL-infiltrating CD4+ T-helper cells (TH) compared with reactive and normal lymph node (NLN) TH cells. Relative to NLNs, FL cells have decreased proportions of naive and central memory but increased proportions of effector memory TH cells. We further show differences in the distribution and anatomical localization of CXCR5+ TH populations that, on the basis of transcription factor analysis, include both regulatory and follicular helper T cells. On Staphylococcus enterotoxin-B stimulation, which stimulates T cells through the T-cell receptor, requires no processing by APCs, and can overcome regulator T cell-mediated suppression, the proportion of uncommitted primed precursor cells, as well as TH2 and TH17 cells is higher in FL cells than in reactive lymph nodes or NLNs. However, the proportion of TH1 and polyfunctional TH cells (producing multiple cytokines simultaneously) is similar in FL cells and NLNs. These data suggest that, although TH-cell differentiation in FL is skewed compared with NLNs, FL TH cells should have the same intrinsic ability to elicit antitumor effector responses as NLN TH cells when tumor suppressive mechanisms are attenuated. [ABSTRACT FROM AUTHOR]

Published
2011
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