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6 results on '"Caldwell, Charles"'

1. Clinical Activity of Abemaciclib (LY2835219), a Cell Cycle Inhibitor Selective for CDK4 and CDK6, in Patients with Relapsed or Refractory Mantle Cell Lymphoma

Author

Morschhauser, Franck, primary, Bouabdallah, Kamal, additional, Stilgenbauer, Stephan, additional, Thieblemont, Catherine, additional, Wolf, Martin, additional, de Guibert, Sophie, additional, Zettl, Florian, additional, Hahka-Kemppinen, Marjo, additional, Xiaohui Wang, David, additional, Brueck, Patrick, additional, Caldwell, Charles, additional, Beckmann, Richard, additional, Gelbert, Lawrence, additional, Cronier, Damien, additional, Lin, Ji, additional, Li, Lily, additional, Chan, Edward M., additional, Pfreundschuh, Michael, additional, Wilhem, Martin, additional, and Hess, Georg, additional

Published
2014
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2. Genome-Wide DNA Methylation Landscape Defines IGHV Mutated and Unmutated B Cell Chronic Lymphocytic Leukemias

Author

Luo, Junfeng, primary, Choi, Justin, additional, Pei, Lirong, additional, Awan, Farrukh, additional, Lee, Eun-Joon, additional, Liu, Jimei, additional, Shull, Austin, additional, McCarthy, Brian A., additional, Wilson, James M., additional, Taylor, Kristen H., additional, Wang, Xinguo, additional, Buckhaults, Phillip Joe, additional, Munn, David H., additional, Caldwell, Charles W., additional, Yan, Xiao-Jie, additional, Chiorazzi, Nicholas, additional, and Shi, Huidong, additional

Published
2012
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5. Relationship Between T200 Antigen Expression and Stages of B Cell Differentiation in Resurgent Hyperplasia of Bone Marrow

Author

Caldwell, Charles W. and Patterson, William P.

Abstract

Using monoclonal antibodies (MoAbs) and dual-parameter flow cytometric techniques, bone marrow mononuclear cells (MMC) from patients with resurgent hyperplasia were analyzed for their coexpression of HLe-1 (T200) and antigens normally associated with particular stages of B cell differentiation. The marrow from those with resurgent hyperplasia contained increased numbers of B cell precursors in multiple stages of differentiation compared to controls, thus providing a useful model system for studies of B cell differentiation. These studies indicate that the quantitative expression of T200 is differentiation-related on normal and malignant B cells and B cell precursors. Immature cells express low amounts of T200, while increasing levels of maturity correlated with increasing amounts of the antigen. This study increases the understanding of relationships between B cell surface antigens and T200 and further demonstrates that B cell hyperplasia occurs commonly in association with bone marrow reactive or resurgent processes. The quantitative, rather than only the qualitative, expression of T200 is therefore a useful marker of B cell differentiation in reactive hyperplasia and in further investigation of B cell malignancy.

Published
1987
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