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11. Role of IbeaGene in Hbmecs Invasion and Biofilm Formation Induced By Neonatal Meningitis Escherichia coli

Author

Zhang, Jimin, Lin, Qiongxi, Wang, Lei, Yang, Shaojie, He, Xiaolong, Peng, Liang, and Cao, Hong

Abstract

Background:Bacterial meningitis is a severe infectious disease that affects the central nervous system and can result in high mortality rates and neurological complications. In neonates, meningitis is mainly caused by neonatal meningitis Escherichia coli(NMEC), which invades the intestine, leading to hematogenous spreadand potential bacterial meningitis through blood-brain barrier. Previous studies indicated that the ability of NMEC to adhere and invade is associated with biofilm formation and a deficiency in ibeA may result in decreased virulence and biofilm-forming ability of avian pathogenic Escherichia coli(APEC). Furthermore, the ibeAgene is positioned downstream of ibeR. Our previous studies have shown that ibeRand ibeAgenes can both regulate the virulence and relevant phenotypes in E. coliK1. However, the effects of ibeRand ibeAon the biofilm formation and invasion of K1 strain remain to be further studied. Recent studies suggest that indole may act as a signaling molecule to regulate the expression of adhesion and biofilm-promoting factors in E. coli. However, the mechanism by which indole affects biofilms is still unclear. This study aimed to investigate the mechanism of ibeAinhibition of indole-induced NMEC invasion and biofilm formation.

Published
2023
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