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Your search keyword '"Garming Legert, Karin"' showing total 4 results
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4 results on '"Garming Legert, Karin"'

2. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease

Author

Munneke, J. Marius, primary, Björklund, Andreas T., additional, Mjösberg, Jenny M., additional, Garming-Legert, Karin, additional, Bernink, Jochem H., additional, Blom, Bianca, additional, Huisman, Cynthia, additional, van Oers, Marinus H. J., additional, Spits, Hergen, additional, Malmberg, Karl-Johan, additional, and Hazenberg, Mette D., additional

Published
2014
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3. Thymic Function Predicts Response to Mesenchymal Stromal Cell Treatment in Chronic GvHD: A Phase II Clinical Study

Author

Boberg, Erik, Von Bahr, Lena, Heldring, Nina, Afram, Gabriel, Iacobaeus, Ellen, Lindström, Carina, Garming-Legert, Karin, Ljungman, Per, Sugars, Rachael, Davies, Lindsay, Kadri, Nadir, and Le Blanc, Katarina

Abstract

There is no established treatment for patients unresponsive to first line therapy for chronic graft versus host disease (cGVHD). Infusion of mesenchymal stromal cells (MSCs) is a promising alternative in this situation, but the treatment efficacy and mechanism of action have not yet been established. Furthermore, there is great need for biomarkers for selecting patients that are more likely to respond to MSC therapy.

Published
2017
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4. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.

Author

Marius Munneke, J., Björklund, Andreas T., Mjösberg, Jenny M., Garming-Legert, Karin, Bernink, Jochem H., Blom, Bianca, Huisman, Cynthia, van Oers, Marinus H. J., Spits, Hergen, Malmberg, Karl-Johan, and Hazenberg, Mette D.

Subjects
*LYMPHOID tissue, *STEM cell transplantation, *EPITHELIAL cells, *NEUTROPHILS, *MONOCYTES
Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemotherapy, and allogeneic HSCT on composition, phenotype, and recovery of circulating innate lymphoid cells (ILCs) in 51 acute leukemia patients. We found that reconstitution of ILC1, ILC2, and NCR-ILC3 was slow compared with that of neutrophils and monocytes. NCR+ ILC3 cells, which are not present in the circulation of healthy persons, appeared both after induction chemotherapy and after allogeneic HSCT. Circulating patient ILCs before transplantation, as well as donor ILCs after transplantation, expressed activation (CD69), proliferation (Ki-67), and tissue homing markers for gut (α4β7, CCR6) and skin (CCR10 and CLA). The proportion of ILCs expressing these markers was associated with a decreased susceptibility to therapy-induced mucositis and acute GVHD. Taken together, these data suggest that ILC recovery and treatment-related tissue damage are interrelated and affect the development of GVHD. [ABSTRACT FROM AUTHOR]

Published
2014
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