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2. The Impact of Cardiovascular Vulnerabilities in Non Hodgkin Lymphoma Patients Treated with Chimeric Antigen Receptor T Cell Therapy

Author

Landego, Ivan, Flynn, Jessica R, Goldman, Adam, Devlin, Sean M., Luttwak, Efrat, Luna De Abia, Alejandro, Corona, Magdalena, Kedmi, Meirav, Sdayoor, Inbal, Fried, Shalev, Shem-Tov, Noga, Shimoni, Avichai, Danylesko, Ivetta, Hammoud, Mohammad, Yerushalmi, Ronit, Nagler, Arnon, Marcus, Ronit, El-Moghraby, Ahmed, Rehman, Mahin, Dahi, Parastoo B., Giralt, Sergio A., Lin, Richard J., Palomba, Maria Lia, Scordo, Michael, Shah, Gunjan L., Perales, Miguel-Angel, Mahmood, Syed, Avigdor, Abraham, Liu, Jennifer, and Shouval, Roni

Abstract

INTRODUCTION:CAR-T therapy is an effective treatment for hematological malignancies. However, in recent years there is a growing body of literature suggesting adverse cardiovascular (CV) events among patients treated with CAR-T therapy. Whether cardiovascular risk factors serve as determinants of CV complications and CAR-T outcomes is unclear. The aim of this study is to investigate the landscape and prognostic role of CV comorbidities in patients with non-Hodgkin lymphoma (NHL) treated with autologous CD19- CAR-T.

Published
2023
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