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1. Hope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation (a national multicenter study)

Author

Jost, Edgar, Schmid, Christoph, Baurmann, Herrad, Blau, Igor, Holderried, Tobias, Hertenstein, Bernd, Hänel, Mathias, Bornhäuser, Martin, Neidlinger, Helga, Kobbe, Guido, Winkler, Julia, Schroeder, Thomas, Bug, Gesine, Hopfer, Olaf, Finke, Jürgen, Hasenkamp, Justin, Krüger, William, Müller, Lutz, Kröger, Nikolaus, Eder, Matthias, Luft, Thomas, Hilgendorf, Inken, Ringhoffer, Mark, Stölzel, Friedrich, Scheid, Christoph, Platzbecker, Uwe, Wortmann, Friederike, Heinicke, Thomas, Wagner, Eva, Klein, Stefan, Burchert, Andreas, Tischer, Johanna, Stelljes, Matthias, Schäfer-Eckart, Kerstin, Wolff, Daniel, Junghanss, Christian, Ritter, Markus, Kaufmann, Martin, Bethge, Wolfgang, Mytilineos, Joannis, Einsel, Hermann, Sockel, Katja, Neu, Annika, Goeckenjan, Maren, Ditschkowski, Markus, Kröger, Nicolaus, Ayuk, Francis A., Stoelzel, Friedrich, Middeke, Jan Moritz, Bertz, Hartmut, Beverungen, David, von Bonin, Malte, Egger-Heidrich, Katharina, Heberling, Lisa, Trautmann-Grill, Karolin, Teipel, Raphael, Fraccaroli, Alessia, Fante, Matthias, Scheid, Christof, Holtick, Udo, Blau, Igor Wolfgang, Wulf, Gerald, Schwerdtfeger, Rainer, Kaun, Stephan, Winter, Susann, Theuser, Catrin, Beyersmann, Jan, Bornhaeuser, Martin, Schmeller, Sandra, and Schetelig, Johannes

Published
2024
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2. Double-Blind, Placebo Controlled, Randomized, Multicenter, Phase II Study to Assess the Efficacy of the High Affinity CXCR4 Inhibitor BL-8040 As Addition to Consolidation Therapy in AML By the SAL and OSHO Leukemia Study Groups

Author

Jaramillo Segura, Sonia, Wass, Maxi, Schaffrath, Judith, Rieger, Kathrin, Nogai, Axel, Hänel, Mathias, Herbst, Regina, Stölzel, Friedrich, Röllig, Christoph, Jost, Edgar, Schlenk, Richard F., Noppeney, Richard, Brandts, Christian H., Krug, Utz, Götze, Katharina S., Buske, Sebastian, Florschütz, Axel, Schubert, Jörg, Opitz, Bernhard, Mohren, Martin, Eßeling, Eva, von Witzendorff, Stephan, Subklewe, Marion, Kaufmann, Martin, Frickhofen, Norbert, Scholz, Christian W., Schäfer-Eckart, Kerstin, Kunzmann, Volker, Schmidt-Hieber, Martin, Sayer, Herbert G., Rank, Andreas, Hemmati, Philipp, Schüler, Frank, Kowoll, Simone, Scheller, Marina, Steighardt, Jörg, Edemir, Bayram, Müller, Lutz Peter, Gliko-Kabir, Irit, Ludwig-Kraus, Beatrice, Edemir, Sabine, Sorani, Ella, Binder, Mascha, Vainstein, Abi, Kadosh, Shaul, Gromann, Cora, Wienke, Andreas, Baldus, Claudia D., Platzbecker, Uwe, Serve, Hubert, Bornhäuser, Martin, Junghanss, Christian, and Müller-Tidow, Carsten

Subjects
Immunology, ddc:610, Cell Biology, Hematology, Biochemistry
Published
2022

3. Increased LFS Following Hematopoietic Cell Transplantation As Compared to Conventional Consolidation Therapy in Patients >60 Years with AML in First Complete Remission and a Matched Donor: Results of a Randomized Phase III Study

Author

Niederwieser, Dietger, primary, Hasenclever, Dirk, additional, Berdel, Wolfgang E., additional, Biemond, Bart J., additional, Al-Ali, Haifa Kathrin, additional, Chalandon, Yves, additional, Van Gelder, Michel, additional, Junghanss, Christian, additional, Gahrton, Goesta, additional, Haenel, Mathias, additional, Hehlmann, Rüdiger, additional, Heinicke, Thomas, additional, Hochhaus, Andreas, additional, Iacobelli, Simona, additional, Kooy, Rien van Marwijk, additional, Kröger, Nicolaus, additional, Janssen, Jeroen J.W.M., additional, Jentzsch, Madlen, additional, Breywisch, Frank, additional, Mohty, Mohamad, additional, Masouridi-Levrat, Stavroula, additional, Ossenkoppele, Gert, additional, Passweg, Jakob, additional, Pönisch, Wolfram, additional, Schetelig, Johannes, additional, Schliemann, Christoph, additional, Schwind, Sebastian, additional, Stelljes, Matthias, additional, Valk, Peter JM, additional, Lowenberg, Bob, additional, and Cornelissen, Jan J., additional

Published
2022
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4. Increased LFS Following Hematopoietic Cell Transplantation As Compared to Conventional Consolidation Therapy in Patients >60 Years with AML in First Complete Remission and a Matched Donor: Results of a Randomized Phase III Study

Author

Niederwieser, Dietger, Hasenclever, Dirk, Berdel, Wolfgang E., Biemond, Bart J., Al-Ali, Haifa Kathrin, Chalandon, Yves, Van Gelder, Michel, Junghanss, Christian, Gahrton, Goesta, Haenel, Mathias, Hehlmann, Rüdiger, Heinicke, Thomas, Hochhaus, Andreas, Iacobelli, Simona, Kooy, Rien van Marwijk, Kröger, Nicolaus, Janssen, Jeroen J.W.M., Jentzsch, Madlen, Breywisch, Frank, Mohty, Mohamad, Masouridi-Levrat, Stavroula, Ossenkoppele, Gert, Passweg, Jakob, Pönisch, Wolfram, Schetelig, Johannes, Schliemann, Christoph, Schwind, Sebastian, Stelljes, Matthias, Valk, Peter JM, Lowenberg, Bob, and Cornelissen, Jan J.

Published
2022
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5. Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)

Author

Kantarjian, Hagop M., Shah, Neil P., Cortes, Jorge E., Baccarani, Michele, Agarwal, Mohan B., Undurraga, María Soledad, Wang, Jianxiang, Kassack Ipiña, Juan Julio, Kim, Dong-Wook, Ogura, Michinori, Pavlovsky, Carolina, Junghanss, Christian, Milone, Jorge H., Nicolini, Franck E., Robak, Tadeusz, Van Droogenbroeck, Jan, Vellenga, Edo, Bradley-Garelik, M. Brigid, Zhu, Chao, and Hochhaus, Andreas

Published
2012
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6. Phenotypes of JAK2-Mutated Polycythemia Vera and Essential Thrombocythemia with and without Thromboembolic Events: Results of the Hinc-207 (OSHO #91) Study

Author

Hennersdorf, Tony, primary, Jaekel, Nadja, additional, Schulze, Susann, additional, Kaempfe, Dietrich, additional, Spohn, Claudia, additional, Moeller, Regina, additional, Schwarz, Maik, additional, Hurtz, Hans-Juergen, additional, Ruessel, Joern, additional, Tornow, Peter, additional, Neef, Ute, additional, Schmalfeld, Marion, additional, Jentsch-Ullrich, Kathleen, additional, Lange, Thoralf, additional, Junghanss, Christian, additional, Kragl, Brigitte, additional, and Al-Ali, Haifa Kathrin, additional

Published
2020
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7. Incidence, Risk Factors, Treatment and Long Term Outcome of Refractory and First Relapse AML Patients in the OSHO Studies

Author

Niederwieser, Dietger, primary, Krahl, Rainer, additional, Kahl, Christoph, additional, Wolf, Hans-Heinrich, additional, Scholl, Sebastian, additional, Cross, Michael, additional, Hegenbart, Ute, additional, Peter, Norma, additional, Niederwieser, Christian, additional, Florschütz, Axel, additional, Reifenrath, Kolija, additional, Zojer, Niklas, additional, Jakob, Christian, additional, Junghanss, Christian, additional, Sayer, Herbert G., additional, Schmidt, Volker, additional, Schwind, Sebastian, additional, Maschmeyer, Georg, additional, Fischer, Thomas, additional, Hochhaus, Andreas, additional, Al-Ali, Haifa Kathrin, additional, and Heinicke, Thomas, additional

Published
2019
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8. Hope for Motherhood: Pregnancy After Allogeneic Hematopoietic Cell Transplantation – a National Multicenter Study

Author

Sockel, Katja, Neu, Annika, Goeckenjan, Maren, Ditschkowski, Markus, Hilgendorf, Inken, Kröger, Nicolaus, Ayuk, Francis A., Stoelzel, Friedrich, Middeke, Jan Moritz, Eder, Matthias, Bethge, Wolfgang, Finke, Jürgen, Bertz, Hartmut, Kobbe, Guido, Kaufmann, Martin, Platzbecker, Uwe, Beverungen, David, Schmid, Christoph, von Bonin, Malte, Egger-Heidrich, Katharina, Heberling, Lisa, Trautmann-Grill, Karolin, Teipel, Raphael, Bug, Gesine, Tischer, Johanna, Fraccaroli, Alessia, Fante, Matthias, Wolff, Daniel, Luft, Thomas, Winkler, Julia, Schäfer-Eckart, Kerstin, Scheid, Christof, Holtick, Udo, Klein, Stefan, Blau, Igor Wolfgang, Burchert, Andreas, Wulf, Gerald, Hasenkamp, Justin, Schwerdtfeger, Rainer, Kaun, Stephan, Junghanss, Christian, Wortmann, Friederike, Winter, Susann, Neidlinger, Helga, Theuser, Catrin, Beyersmann, Jan, Bornhaeuser, Martin, Schmeller, Sandra, Schetelig, Johannes, Jost, Edgar, Schmid, Christoph, Baurmann, Herrad, Blau, Igor, Holderried, Tobias, Hertenstein, Bernd, Hänel, Mathias, Bornhäuser, Martin, Neidlinger, Helga, Kobbe, Guido, Winkler, Julia, Schroeder, Thomas, Bug, Gesine, Hopfer, Olaf, Finke, Jürgen, Hasenkamp, Justin, Krüger, William, Müller, Lutz, Kröger, Nikolaus, Eder, Matthias, Luft, Thomas, Hilgendorf, Inken, Ringhoffer, Mark, Stölzel, Friedrich, Scheid, Christoph, Platzbecker, Uwe, Wortmann, Friederike, Heinicke, Thomas, Wagner, Eva, Klein, Stefan, Burchert, Andreas, Tischer, Johanna, Stelljes, Matthias, Schäfer-Eckart, Kerstin, Wolff, Daniel, Junghanss, Christian, Ritter, Markus, Kaufmann, Martin, Bethge, Wolfgang, Mytilineos, Joannis, and Einsel, Hermann

Abstract

•Successful pregnancies are possible among female alloHCT recipients, although birth rate is more than six times lower than in the general population.•Key factors increasing the chance of motherhood were younger age at HCT, non-malignant disease, no TBI or dose <8Gy and RIC/NMA conditioning

Published
2024
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10. The Addition of Sorafenib to Standard AML Treatment Results in a Substantial Reduction in Relapse Risk and Improved Survival. Updated Results from Long-Term Follow-up of the Randomized-Controlled Soraml Trial

Author

Rollig, Christoph, primary, Serve, Hubert, additional, Hüttmann, Andreas, additional, Noppeney, Richard, additional, Müller-Tidow, Carsten, additional, Krug, Utz, additional, Baldus, Claudia D., additional, Brandts, Christian H., additional, Kunzmann, Volker, additional, Einsele, Hermann, additional, Krämer, Alwin, additional, Schäfer-Eckart, Kerstin, additional, Neubauer, Andreas, additional, Burchert, Andreas, additional, Giagounidis, Aristoteles, additional, Krause, Stefan W., additional, Mackensen, Andreas, additional, Aulitzky, Walter E., additional, Herbst, Regina, additional, Hänel, Mathias, additional, Kiani, Alexander, additional, Frickhofen, Norbert, additional, Kullmer, Johannes, additional, Kaiser, Ulrich, additional, Link, Hartmut, additional, Geer, Thomas, additional, Reichle, Albrecht, additional, Junghanss, Christian, additional, Repp, Roland, additional, Heits, Frank, additional, Durk, Heinz Albert, additional, Illmer, Thomas, additional, Bornhäuser, Martin, additional, Schaich, Markus, additional, Parmentier, Stefani Barbara, additional, Goerner, Martin, additional, Thiede, Christian, additional, von Bonin, Malte, additional, Schetelig, Johannes, additional, Kramer, Michael, additional, Berdel, Wolfgang E., additional, and Ehninger, Gerhard, additional

Published
2017
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11. Comparison of Treatment Strategies in Patients over 60 Years with AML: Final Analysis of a Prospective Randomized German AML Intergroup Study

Author

Niederwieser, Dietger, primary, Hoffmann, Verena Sophia, additional, Pfirrmann, Markus, additional, Al-Ali, Haifa Kathrin, additional, Schwind, Sebastian, additional, Vucinic, Vladan, additional, Krahl, Rainer, additional, Kahl, Christoph, additional, Wolf, Hans-Heinrich, additional, Kreibich, Ute, additional, Hähling, Detlef, additional, Hegenbart, Ute, additional, Hirt, Carsten, additional, Peter, Norma, additional, Florschuetz, Axel, additional, Reifenrath, Kolja, additional, Schulze, Antje, additional, Zojer, Niklas, additional, Scholl, Sebastian, additional, Junghanss, Christian, additional, Pönisch, Wolfram, additional, Heyn, Simone, additional, Sayer, Herbert G., additional, Hochhaus, Andreas, additional, Heinicke, Thomas, additional, Fischer, Thomas, additional, Krämer, Alwin, additional, Dreger, Peter, additional, Maschmeyer, Georg, additional, Krug, Utz, additional, Sauerland, Maria Christina, additional, Heinecke, Achim, additional, Hehlmann, Rüdiger, additional, Lengfelder, Eva, additional, Hiddemann, Wolfgang, additional, Serve, Hubert, additional, Müller-Tidow, Carsten, additional, Berdel, Wolfgang E, additional, and Büchner, Thomas, additional

Published
2016
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12. Improved Safety with the Use of Subcutaneous Bortezomib in Combination with Panobinostat and Dexamethasone: Preliminary Data from a Panobinostat Global Expanded Treatment Protocol

Author

Guenther, Andreas, primary, Mügge, Lars-Olof, additional, Haenel, Mathias, additional, Schjesvold, Fredrik H., additional, Lechner, Daniel, additional, Yaser, Sameer, additional, Hebart, Holger, additional, Gisslinger, Heinz, additional, Greil, Richard, additional, Gunsilius, Eberhard, additional, Goerner, Martin, additional, Weisel, Katja, additional, Dürig, Jan, additional, Elemary, Mohamed, additional, Wolleschak, Denise, additional, Klein, Stefan A., additional, Munder, Markus, additional, Kiani, Alexander, additional, Nahi, Hareth, additional, Junghanss, Christian, additional, Campello-Iddison, Valerie, additional, Deniau, Ythier, additional, Feng, Xiaoshu, additional, and Einsele, Hermann, additional

Published
2016
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13. Hypomethylating Agents and Casein Kinase 2 Inhibitor Act Synergistic and Reveal Significant Anti-Leukemic Effects in Acute Lymphoblastic Leukemia Cells

Author

Roolf, Catrin, primary, Richter, Anna, additional, Konkolefski, Christoph, additional, Khodamoradi, Yascha, additional, Knuebel, Gudrun, additional, Sekora, Anett, additional, Stenzel, Jan, additional, Krause, Bernd Joachim, additional, Vollmar, Brigitte, additional, Jeremias, Irmela, additional, Panse, Jens P., additional, Murua Escobar, Hugo, additional, and Junghanss, Christian, additional

Published
2016
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14. Impact of Infusion Rate on the Early Engraftment Following Allogeneic Intra Bone Marrow Infusion of Hematopoietic Stem Cells in a Canine DLA-Identical Reduced Intensity Transplantation Model

Author

Schaefer, Stephanie, primary, Werner, Juliane, additional, Lange, Sandra, additional, Neumann, Katja, additional, Machka, Christoph, additional, murua Escobar, Hugo, additional, Roolf, Catrin, additional, Knuebel, Gudrun, additional, Lindner, Iris, additional, Vogel, Heike, additional, Freund, Mathias, additional, and Junghanss, Christian, additional

Published
2015
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15. Higher Incidence of Secondary AML and Adverse Molecular Markers, Together with Lower CR and Higher AML Related Death Rates in Elderly Compared to Younger Patients: Results from 2435 Patients Included in the Two German AML Intergroup Studies

Author

Niederwieser, Dietger, primary, Hoffmann, Verena Sophia, additional, Krug, Utz, additional, Krahl, Rainer, additional, Sauerland, Christina, additional, Spiekermann, Karsten, additional, Bohlander, Stefan K., additional, Hegenbart, Ute, additional, Poenisch, Wolfram, additional, Vucinic, Vladan, additional, Cross, Michael, additional, Jaekel, Nadja, additional, Pfirrmann, Markus, additional, Schulze, Antje, additional, Kraemer, Alwin, additional, Maschmeyer, Georg, additional, Junghanss, Christian, additional, Scholl, Sebastian, additional, Jakob, Christian, additional, Heinicke, Thomas, additional, Haehling, Detlev, additional, Peter, Norma, additional, Kreibich, Ute, additional, Busemann, Christoph, additional, Al-Ali, Haifa Kathrin, additional, Elmaagacli, Ahmet H., additional, Opitz, B, additional, Wolf, Hans-Heinrich, additional, Hiddemann, Wolfgang, additional, Berdel, Wolfgang E, additional, and Buechner, Thomas, additional

Published
2015
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16. Imatinib (IM) in Combination with Hydroxyurea Showed Significantly Lower Major Molecular Response Rates at 6 Months but Similar MMR at 18 Months in Patients with CML1st CP Compared to IM Alone. Final Results of the CML2004 Study. NCT 02480608

Author

Lange, Thoralf, Krahl, Rainer, von Grünhagen, Ulrich, Al-Ali, Haifa Kathrin, Andreas, Schwarzer, Jentsch-Ulrich, Kathleen, Spohn, Claudia, Lakner, Volker, Assmann, Michael, Junghanss, Christian, Pfirrmann, Markus, Gil, Arthur, Hehlmann, Rüdiger, Deininger, Michael W., and Niederwieser, Dietger

Published
2017
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17. Final Results of a Prospective Randomized Multicenter Phase III Trial Comparing Treosulfan/Fludarabine to Reduced Intensity Conditioning with Busulfan/Fludarabine Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Elderly or Comorbid Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome

Author

Beelen, Dietrich W, Trenschel, Rudolf, Stelljes, Matthias, Masszi, Tamás, Reményi, Péter, Wagner-Drouet, Eva-Maria Maria, Dreger, Peter, Bethge, Wolfgang, Ciceri, Fabio, Stoelzel, Friedrich, Junghanss, Christian, Michallet, Mauricette, and Markiewicz, Miroslaw

Published
2017
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18. Nilotinib (Tasigna®) and Chemotherapy for First-Line Treatment in Elderly Patients with De Novo Philadelphia Chromosome/BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL): A Trial of the European Working Group for Adult ALL (EWALL-PH-02)

Author

Ottmann, Oliver G., primary, Pfeifer, Heike, additional, Cayuela, Jean-Michel, additional, Spiekermann, Karsten, additional, Beck, Joachim, additional, Jung, Wolfram E, additional, Viardot, Andreas, additional, Kerstin, Schäfer-Eckart, additional, Reichle, Albrecht, additional, Maury, Sébastien, additional, Schmitz, Norbert, additional, Heidenreich, Daniela, additional, Panse, Jens, additional, Junghanß, Christian, additional, Raffoux, Emmanuel, additional, Suarez, Felipe, additional, Guillerm, Gäelle, additional, Alexis, Magda, additional, Lissandre, Severine, additional, Huguet, Françoise, additional, Isnard, Françoise, additional, Lepretre, Stephane, additional, Escoffre-Barbe, Martine, additional, Ribera, Josep-Maria, additional, Goekbuget, Nicola, additional, Dombret, Herve, additional, Hoelzer, Dieter, additional, and Rousselot, Philippe, additional

Published
2014
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19. Prognostic Factors for Overall Survival in Relapsed Acute Myeloid Leukemia

Author

Heinicke, Thomas, primary, Krahl, Rainer, additional, Kahl, Christoph, additional, Scholl, Sebastian, additional, Wolf, Hans-Heinrich, additional, Hähling, Detlev, additional, Hegenbart, Ute, additional, Peter, Norma, additional, Schulze, Antje, additional, Florschütz, Axel, additional, Reifenrath, Kolja, additional, Zojer, Niklas, additional, Jakob, Christian, additional, Junghanss, Christian, additional, Sayer, Herbert G., additional, Maschmeyer, Georg, additional, Hochhaus, Andreas, additional, Fischer, Thomas, additional, Niederwieser, Dietger, additional, and Al-Ali, Haifa Kathrin, additional

Published
2014
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20. Response to Lenalidomide, Doxorubicin and Dexamethasone (RAD) in Newly Diagnosed Multiple Myeloma Is Independent of Cytogenetic Risk and Retained after Double Stem Cell Transplant

Author

Knop, Stefan, primary, Langer, Christian, additional, Engelhardt, Monika, additional, Mügge, Lars-Olof, additional, Reichle, Albrecht, additional, Rösler, Wolf, additional, Bassermann, Florian, additional, Hertenstein, Bernd, additional, Sturm, Isrid, additional, Röllig, Christoph, additional, Ostermann, Helmut, additional, Schäfer-Eckart, Kerstin, additional, Ringhoffer, Mark, additional, Günther, Andreas, additional, Junghanss, Christian, additional, Biersack, Harald, additional, Strifler, Susanne, additional, Bachinger, Andreas, additional, Einsele, Hermann, additional, and Bargou, Ralf C., additional

Published
2014
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21. Long Term Follow up of the AML97-Study for Patients with AML Older Than 60 Years: A Study of the East German Hematology and Oncology Study Group (OSHO)

Author

Kahl, Christoph, primary, Krahl, Rainer, additional, Al-Ali, Haifa Kathrin, additional, Sayer, Herbert G., additional, Schulze, Antje, additional, Herold, Michael, additional, Hänel, Mathias, additional, Scholl, Sebastian, additional, Hochhaus, Andreas, additional, Uharek, Lutz, additional, Maschmeyer, Georg, additional, Hähling, Detlev, additional, Junghanss, Christian, additional, Peter, Norma, additional, Kämpfe, Dietrich, additional, Kettner, Erika, additional, Heinicke, Thomas, additional, Fischer, Thomas, additional, Kreibich, Ute, additional, Wolf, Hans-Heinrich, additional, and Niederwieser, Dietger, additional

Published
2014
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22. Higher Leukemia Free Survival after Post-Induction Hematopoietic Cell Transplantation Compared to Consolidation Therapy in Patients >60 Years with Acute Myelogenous Leukemia (AML): Report from the AML 2004 East German Study Group (OSHO)

Author

Niederwieser, Dietger, primary, Al-Ali, Haifa Kathrin, additional, Krahl, Rainer, additional, Kahl, Christoph, additional, Wolf, Hans-Heinrich, additional, Kreibich, Ute, additional, Vucinic, Vladan, additional, Haehling, Detlev, additional, Hegenbart, Ute, additional, Kraemer, Alwin, additional, Hirt, Carsten, additional, Peter, Norma, additional, Opitz, Bernhard, additional, Florschütz, Axel, additional, Reifenrath, Kolja, additional, Schulze, Antje, additional, Zojer, Niklas, additional, Scholl, Sebastian, additional, Jakob, Christian, additional, Junghanss, Christian, additional, Pönisch, Wolfram, additional, Heyn, Simone, additional, Sayer, Herbert G., additional, Hochhaus, Andreas, additional, Heinicke, Thomas, additional, Fischer, Thomas, additional, Maschmeyer, Georg, additional, and Dreger, Peter, additional

Published
2014
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23. Engraftment Effects of Intra Bone Marrow Compared to Intravenous Transplantation of Allogeneic Hematopoietic Stem Cells Following a Reduced Intensity Conditioning in a DLA-Identical Canine Littermate Model

Author

Werner, Juliane, primary, Schaefer, Stephanie, additional, Lange, Sandra, additional, Machka, Christoph, additional, Knuebel, Gudrun, additional, Sekora, Anett, additional, Roolf, Catrin, additional, Murua Escobar, Hugo, additional, Vogel, Heike, additional, Lindner, Iris, additional, Freund, Mathias, additional, and Junghanss, Christian, additional

Published
2014
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24. Polymorphism nt7778G/T In Mitochondrial ATP8 Gene Promotes Protective Effect On Reactive Oxygen Species Level In Murine Hematopoietic Cells During Aging

Author

Kretzschmar, Christin, primary, Roolf, Catrin, additional, Timmer, Katrin, additional, Knübel, Gudrun, additional, Sekora, Anett, additional, Müller, Sarah, additional, Tiedge, Markus, additional, Baltrusch, Simone, additional, Köhling, Rüdiger, additional, Ibrahim, Saleh, additional, Freund, Mathias, additional, and Junghanss, Christian, additional

Published
2013
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27. Increasing The Dose Of AraC In Consolidation Therapy Does Not Lead To Higher Overall Survival Or Improved Relapse Incidence In Patients With AML Over The Age Of 60 Years

Author

Niederwieser, Dietger, primary, Krahl, Rainer, additional, Jakob, Christian, additional, Heinicke, Thomas, additional, Kahl, Christoph, additional, Schulze, Antje, additional, Wolf, Hans-Heinrich, additional, Opitz, Bernhard, additional, Kreibich, Ute, additional, Rothmann, Frank, additional, Junghanss, Christian, additional, Haehling, Detlev, additional, Schulze, Manfred, additional, Peter, Norma, additional, Hegenbart, Ute, additional, Al-Ali, Haifa Kathrin, additional, Hirt, Carsten, additional, Poenisch, Wolfram, additional, Lange, Thoralf, additional, Heyn, Simone, additional, Vucinic, Vladan, additional, Bartsch, Kristina, additional, Fischer, Thomas, additional, Maschmeyer, Georg, additional, and Hochhaus, Andreas, additional

Published
2013
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28. Prognostic Factors For Overall Survival In Elderly Patients With Relapsed Acute Myeloid Leukemia – Retrospective Study On Behalf Of The East German Study Group For Hematology and Oncology (OSHO)

Author

Heinicke, Thomas, primary, Krahl, Rainer, additional, Jakob, Christian, additional, Kahl, Christoph, additional, Wolf, Hans-Heinrich, additional, Kreibich, Ute, additional, Rothmann, Frank, additional, Hähling, Detlev, additional, Schulze, Manfred, additional, Wedding, Ulrich, additional, Hegenbart, Ute, additional, Hirt, Carsten, additional, Peter, Norma, additional, Opitz, Bernhard, additional, Schulze, Antje, additional, Junghanss, Christian, additional, Hochhaus, Andreas, additional, Fischer, Thomas, additional, Niederwieser, Dietger, additional, and Al-Ali, Haifa Kathrin, additional

Published
2013
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29. Conditioning with Treosulfan and Fludarabine for Patients with Refractory or Relapsed Non-Hodgkin Lymphoma (NHL),

Author

Schmitt, Michael, primary, Trenschel, Rudolf, additional, Sayer, Herbert G., additional, Schneider, Catarina, additional, Glass, Aenne, additional, Hilgendorf, Inken, additional, Treschl, Anne, additional, Junghanss, Christian, additional, Borchert, Kersten, additional, Koenigsmann, Michael, additional, Casper, Jochen, additional, Beelen, Dietrich, additional, Freund, Mathias, additional, and Kahl, Christoph, additional

Published
2011
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31. Intra-Bone Marrow Transplantation of CD34+ Enriched Grafts Following a Non-Myeloablative Conditioning Allows Successful Engraftment In DLA-Identical Canine Litters.

Author

Knueppel, Anne, primary, Killian, Doreen, additional, Lange, Sandra, additional, Vogel, Heike, additional, Lindner, Iris, additional, Dunkelmann, Simone, additional, Prall, Friedrich, additional, Freund, Mathias, additional, Knuebel, Gudrun, additional, Sekora, Anett, additional, and Junghanss, Christian, additional

Published
2010
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32. Low Levels of Global (LINE) and CDH13 Methylation at Diagnosis and Rapid Clearance of Marrow Blasts Correlate with A Better Haematological Response to Azacitidine in Patients with Newly Diagnosed and Refractory/Relapsed AML Not Eligible for or Resistant to Chemotherapy: A Multi-Centre Phase I/II-Study of the East German Haematology and Oncology Study Group (OSHO).

Author

Cross, Michael, primary, Jaekel, Nadja, additional, Krahl, Rainer, additional, Junghanss, Christian, additional, Maschmeyer, Georg, additional, Tran, Thao, additional, Hoppe, Gisa, additional, Niederwieser, Dietger, additional, and Al-Ali, Haifa Kathrin, additional

Published
2009
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33. Reduction of Relapse Incidence and Improvement of Leukemia Free Survival by Allogeneic Stem Cell Transplantation in Patients with AML and Normal Karyotype Irrespective of the FLT3-ITD Status.

Author

Schueler, Frank, primary, Basara, Nadezda, additional, Maschmeyer, Georg, additional, Fischer, Thomas, additional, Herold, Michael, additional, Sayer, Herbert G., additional, Wolf, Hans-Heinrich, additional, Kreibich, Ute, additional, Haehling, Detlev, additional, Doelken, Gottfried, additional, Junghanss, Christian, additional, Grobe, Norbert, additional, Krahl, Rainer, additional, Al-Ali, Haifa Kathrin, additional, Poenisch, Wolfram, additional, and Niederwieser, Dietger, additional

Published
2009
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34. Experience with a Therapeutic Platelet Transfusion Strategy in Acute Myeloid Leukemia: Preliminary Results of a Randomized Multicenter Study After Enrolment of 175 Patients.

Author

Wandt, Hannes, primary, Schaefer-Eckart, Kerstin, additional, Pilz, Bettina, additional, Thalheimer, Markus, additional, Ho, Anthony D, additional, Schaich, Markus, additional, Kaufmann, Martin, additional, Aulitzky, Walter E., additional, Haenel, Mathias, additional, Herbst, Regina, additional, Doelken, Gottfried, additional, Klenner, Anne Friederike, additional, Freund, Mathias, additional, Junghanss, Christian, additional, and Ehninger, Gerhard, additional

Published
2009
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37. Ten Year Follow up Analysis of the OSHO Phase III Trial (AML 96) Comparing Different Application Modes of AraC in Patients below 60 Years with Acute Myeloid Leukemia (AML): No Impact of AraCApplication Mode on Remission Rate, Toxicity, Disease-Free Survival or Overall Survival

Author

Becker, Cornelia, primary, Krahl, Rainer, primary, Schulze, Antje, primary, Maschmeyer, Georg, primary, Junghanß, Christian, primary, Franke, Astrid, primary, Peter, Norma, primary, Haenel, Mathias, primary, Wedding, Ulrich, primary, Wolf, Hans-Heinrich, primary, Haehling, Detlev, primary, Meran, Johannes, primary, Doelken, Gottfried, primary, Kaempfe, Dietrich, primary, Kettner, Erika, primary, Grobe, Norbert, primary, Florschuetz, Axel, primary, Kreibich, Ute, primary, Schirmer, Veronika, primary, Ittel, Thomas, primary, Schulze, Mathias, primary, Huhn, Renate, primary, Zschuppe, Ernst, primary, Opitz, Bernd, primary, Assmann, Michael, primary, Hasenclever, Dirk, primary, Poenisch, Wolfram, primary, Helbig, Werner, primary, and Niederwieser, Dietger W., primary

Published
2008
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38. Severity of Chronic Gvhd and Personality Determines Quality of Life and the Activity Profile: Results of a Prospective German Multicenter Validation Trial

Author

Wolff, Daniel, primary, Herzberg, Philipp, additional, Heussner, Pia, additional, Mumm, Friederike, additional, Hilgendorf, Inken, additional, von Harsdorf, Stephanie, additional, Gerbitz, Armin, additional, Greinix, Hildegard T., additional, Hahn, Joachim, additional, Junghanss, Christian, additional, and Holler, Ernst, additional

Published
2008
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42. Allogeneic Blood Stem Cell Transplantation in Patients with Hematologic Diseases after Conditioning with Treosulfan and Fludarabine.

Author

Casper, Jochen, primary, Wilhelm, Stefan, primary, Steiner, Beate, primary, Wolff, Daniel, primary, Grobe, Norbert, primary, Haehling, Detlev, primary, Hartung, Gernot, primary, Hilgendorf, Inken, primary, Lueck, Andreas, primary, Junghanss, Christian, primary, Kahl, Christoph, primary, Pichlmeier, Uwe, primary, and Freund, Mathias, primary

Published
2005
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43. Casein Kinase II Inhibition By CX-4945 and Epigenetic Modulation By Decitabine Demonstrate Significant Antiproliferative Activity As Single Agents As Well As in Combination in Acute B-Lymphoblastic Leukemia Cells

Author

Richter, Anna, Roolf, Catrin, Sender, Sina, Kong, Weibo, Knübel, Gudrun, Sekora, Anett, Gladbach, Yvonne Saara, Hamed, Mohamed, Fuellen, Georg, Vollmar, Brigitte, Jeremias, Irmela, Panse, Jens P., Murua Escobar, Hugo, and Junghanss, Christian

Abstract

Introduction:Aberrant PI3K/AKT signaling is frequently observed in B cell precursor acute lymphoblastic leukemia (B-ALL) resulting in increased cell proliferation and survival. Casein kinase II (CK2) is a regulator of both, PI3K signaling and epigenetic mechanisms in hematological neoplasms. CK2 induces downregulation of de novomethylation and DNA damage response control. However, it is unclear if maintenance methylation is also influenced by CK2. We performed extended in vitroand in vivoanalyses with CK2 inhibitor CX-4945 (CX) alone and in combination with hypomethylating agent Decitabine (DEC) or PI3K pathway inhibitors to enhance anti-leukemic efficiency. We hypothesized that demethylation and CK2 blockade act synergistically and have anti-leukemic activity.

Published
2017
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44. Nilotinib (Tasigna®) and Chemotherapy for First-Line Treatment in Elderly Patients with De NovoPhiladelphia Chromosome/BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL): A Trial of the European Working Group for Adult ALL (EWALL-PH-02)

Author

Ottmann, Oliver G., Pfeifer, Heike, Cayuela, Jean-Michel, Spiekermann, Karsten, Beck, Joachim, Jung, Wolfram E, Viardot, Andreas, Kerstin, Schäfer-Eckart, Reichle, Albrecht, Maury, Sébastien, Schmitz, Norbert, Heidenreich, Daniela, Panse, Jens, Junghanß, Christian, Raffoux, Emmanuel, Suarez, Felipe, Guillerm, Gäelle, Alexis, Magda, Lissandre, Severine, Huguet, Françoise, Isnard, Françoise, Lepretre, Stephane, Escoffre-Barbe, Martine, Ribera, Josep-Maria, Goekbuget, Nicola, Dombret, Herve, Hoelzer, Dieter, and Rousselot, Philippe

Published
2014
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