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12 results on '"Knisbacher, Binyamin A."'

1. Proteogenomic Analysis of SF3B1 mut CLL Reveals Altered Protein Signaling Cascades and Metabolomic Pathways

Author

Klaeger, Susan, primary, Tausch, Eugen, additional, Knisbacher, Binyamin A., additional, Apffel, Annie, additional, Clauser, Karl R, additional, Williams, Corinne, additional, Clish, Clary, additional, Rassenti, Laura Z., additional, Kipps, Thomas J., additional, Fischer, Kirsten, additional, Hallek, Michael, additional, Gillette, Michael A, additional, Neuberg, Donna S., additional, Getz, Gad, additional, Mani, DR, additional, Stilgenbauer, Stephan, additional, Wu, Catherine J., additional, and Carr, Steven A, additional

Published
2022
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2. Association of Clonal Hematopoiesis of Indeterminate Potential with Time to First Treatment, Incidence of Richter's Syndrome, and Overall Survival in Patients with Chronic Lymphocytic Leukemia

Author

Vijenthira, Abi, primary, Sekar, Aswin, additional, Gibson, Christopher J., additional, Martindale, Stephen P., additional, Fardoun, Rayan, additional, Tyekucheva, Svitlana, additional, Ren, Yue, additional, Fernandes, Stacey M., additional, Knisbacher, Binyamin A., additional, Hahn, Cynthia K., additional, Getz, Gad, additional, Wu, Catherine J., additional, Davids, Matthew S., additional, and Brown, Jennifer R., additional

Published
2022
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4. Prevalence of Clonal Hematopoiesis of Indeterminate Potential in Patients with Monoclonal B-Cell Lymphocytosis Compared to Untreated Chronic Lymphocytic Leukemia

Author

Patel, Anisha V., primary, Vijenthira, Abirami, additional, Sekar, Aswin, additional, Gibson, Christopher J., additional, Martindale, Stephen P., additional, Fardoun, Rayan, additional, Tyekucheva, Svitlana, additional, Fernandes, Stacey M., additional, Knisbacher, Binyamin A., additional, Hahn, Cynthia K., additional, Getz, Gad, additional, Wu, Catherine J., additional, Davids, Matthew S., additional, and Brown, Jennifer R., additional

Published
2022
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5. Evolutionary History of Transformation from Chronic Lymphocytic Leukemia to Richter Syndrome

Author

Parry, Erin Michelle, primary, Guieze, Romain, additional, Leshchiner, Ignaty, additional, Johnson, Connor, additional, Tausch, Eugen, additional, Parikh, Sameer A., additional, Lemvigh, Camilla K, additional, Broséus, Julien, additional, Hergalant, Sébastien, additional, Messer, Connor, additional, Utro, Filippo, additional, Levovitz, Chaya, additional, Rhrissorrakrai, Kahn, additional, Li, Liang, additional, Li, Shuqiang, additional, Fell, Geoffrey G, additional, Redd, Robert A., additional, Lin, Ziao, additional, Knisbacher, Binyamin A., additional, Schneider, Christof, additional, Fernandes, Stacey M., additional, Hess, Julian M., additional, Rassenti, Laura Z., additional, Kipps, Thomas J., additional, Jain, Nitin, additional, Wierda, William G., additional, Cymbalista, Florence, additional, Feugier, Pierre, additional, Kay, Neil E., additional, Livak, Kenneth J, additional, Danysh, Brian P, additional, Stewart, Chip, additional, Neuberg, Donna S., additional, Davids, Matthew S., additional, Brown, Jennifer R., additional, Parida, Laxmi, additional, Stilgenbauer, Stephan, additional, Getz, Gad, additional, and Wu, Catherine J., additional

Published
2022
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6. ZNF683 (Hobit) Marks a CD8+ T Cell Population Associated with Anti-Tumor Immunity Following Anti-PD-1 Therapy for Richter Syndrome

Author

Lemvigh, Camilla K, primary, Parry, Erin Michelle, additional, Deng, Stephanie L, additional, Dangle, Nathan J, additional, Ruthen, Neil, additional, Knisbacher, Binyamin A., additional, Broséus, Julien, additional, Hergalant, Sébastien, additional, Guieze, Romain, additional, Li, Shuqiang, additional, Yin, Shanye, additional, Huang, Teddy, additional, Livak, Kenneth J, additional, Getz, Gad, additional, Neuberg, Donna S., additional, Feugier, Pierre, additional, Kharchenko, Peter, additional, Wierda, William G., additional, Olsen, Lars Rønn, additional, Jain, Nitin, additional, and Wu, Catherine J., additional

Published
2022
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7. The CLL-1100 Project: Towards Complete Genomic Characterization and Improved Prognostics for CLL

Author

Knisbacher, Binyamin A., primary, Lin, Ziao, additional, Hahn, Cynthia K., additional, Nadeu, Ferran, additional, Duran-Ferrer, Martí, additional, Stevenson, Kristen E., additional, Tausch, Eugen, additional, Barbera-Mourelle, Alex, additional, Dunford, Andrew, additional, Anand, Shankara, additional, Delgado, Julio, additional, Hess, Julian M., additional, Taylor-Weiner, Amaro, additional, Kretzmer, Helene, additional, Bousquets Muñoz, Pablo, additional, Shaughnessy, Conner J., additional, Fernandes, Stacey M., additional, Sivina, Mariela, additional, Rassenti, Laura Z., additional, Meissner, Alexander, additional, Wiestner, Adrian, additional, Burger, Jan A., additional, Kipps, Thomas J., additional, Brown, Jennifer R, additional, Hallek, Michael, additional, Aguet, François, additional, Neuberg, Donna S., additional, Puente, Xose S, additional, Stewart, Chip, additional, Martín-Subero, José I., additional, Stilgenbauer, Stephan, additional, Wu, Catherine J., additional, Campo, Elías, additional, and Getz, Gad, additional

Published
2020
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8. RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Author

Gutierrez, Catherine, primary, Ouspenskaia, Tamara, additional, Fu, Doris, additional, Waddicor, Peyton, additional, Biran, Anat, additional, Liani, Aviv, additional, Lazarian, Gregory, additional, Ten Hacken, Elisa, additional, Witten, Elizabeth, additional, Regis, Fara Faye, additional, Joyal, Heather, additional, Billington, Leah, additional, Lucas, Fabienne, additional, Zheng, Mei, additional, Tye, Blake, additional, Hernandez-Sanchez, Maria, additional, Quijada Álamo, Miguel, additional, Li, Shuqiang, additional, Knisbacher, Binyamin A., additional, Lin, Ziao, additional, Al'Khafaji, Aziz, additional, Wang, Lili, additional, Livak, Kenneth J., additional, Neuberg, Donna S., additional, Cymbalista, Florence, additional, Getz, Gad, additional, Churchman, Stirling, additional, Carrasco, Ruben D., additional, Shao, Sichen, additional, Regev, Aviv, additional, and Wu, Catherine J., additional

Published
2020
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11. ZNF683(Hobit) Marks a CD8+ T Cell Population Associated with Anti-Tumor Immunity Following Anti-PD-1 Therapy for Richter Syndrome

Author

Lemvigh, Camilla K, Parry, Erin Michelle, Deng, Stephanie L, Dangle, Nathan J, Ruthen, Neil, Knisbacher, Binyamin A., Broséus, Julien, Hergalant, Sébastien, Guieze, Romain, Li, Shuqiang, Yin, Shanye, Huang, Teddy, Livak, Kenneth J, Getz, Gad, Neuberg, Donna S., Feugier, Pierre, Kharchenko, Peter, Wierda, William G., Olsen, Lars Rønn, Jain, Nitin, and Wu, Catherine J.

Published
2022
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12. RPS15and TP53Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Author

Gutierrez, Catherine, Ouspenskaia, Tamara, Fu, Doris, Waddicor, Peyton, Biran, Anat, Liani, Aviv, Lazarian, Gregory, Ten Hacken, Elisa, Witten, Elizabeth, Regis, Fara Faye, Joyal, Heather, Billington, Leah, Lucas, Fabienne, Zheng, Mei, Tye, Blake, Hernandez-Sanchez, Maria, Quijada Álamo, Miguel, Li, Shuqiang, Knisbacher, Binyamin A., Lin, Ziao, Al'Khafaji, Aziz, Wang, Lili, Livak, Kenneth J., Neuberg, Donna S., Cymbalista, Florence, Getz, Gad, Churchman, Stirling, Carrasco, Ruben D., Shao, Sichen, Regev, Aviv, and Wu, Catherine J.

Abstract

Amongst the novel putative drivers identified by large-scale sequencing studies of chronic lymphocytic leukemia (CLL) is the ribosomal protein RPS15. Mutated in 5.3% of CLL, it co-occurs with heterozygous TP53alterations in 36% of RPS15-mutated samples. Mutation of this mediator of ribosome maturation and translation is associated with poor disease prognosis and enriched in cohorts with del(17p) and relapsed CLL, suggesting a role in disease progression and therapeutic resistance. However, the impact of RPS15mutation on B cell function and CLL development, in the presence or absence of TP53mutation, has yet to be characterized. To this end, we developed overexpression HG3 CLL cell lines modeling four common RPS15mutations (G134R, H137Y, S138F, and S139F) and a conditional knock-in mouse model of the S138F mutation with and without heterozygous Trp53deletion (generated by crossing Rps15and Trp53mutant mice with Cd19-Cre mice).

Published
2020
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