1. Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients
- Author
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Obiageli N. Onwuazor, Jaimie Claudio, A. Keith Stewart, John D. Shaughnessy, Bart Barlogie, Xiao-Yan Wen, Lihua Zhuang, Esther Masih-Khan, and Ding Yan Wang
- Subjects
musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,Immunology ,DNA Mutational Analysis ,Chromosomal translocation ,medicine.disease_cause ,Fibroblast growth factor ,Biochemistry ,Polymorphism, Single Nucleotide ,Translocation, Genetic ,Bone Marrow ,Medicine ,SNP ,Humans ,Point Mutation ,Protein Isoforms ,Receptor, Fibroblast Growth Factor, Type 3 ,Multiple myeloma ,Chromosomes, Human, Pair 14 ,Mutation ,business.industry ,Reverse Transcriptase Polymerase Chain Reaction ,Point mutation ,Cell Biology ,Hematology ,DNA, Neoplasm ,Fibroblast growth factor receptor 3 ,Protein-Tyrosine Kinases ,medicine.disease ,Molecular biology ,Receptors, Fibroblast Growth Factor ,Neoplasm Proteins ,stomatognathic diseases ,Mutagenesis, Insertional ,medicine.anatomical_structure ,Bone marrow ,Chromosomes, Human, Pair 4 ,business ,Multiple Myeloma - Abstract
The t(4;14) translocation in multiple myeloma (MM) is identified in 15% of patient samples and dysregulates both FGFR3 and multiple myeloma SET domain (MMSET).[1][1] Activating FGFR3 mutations are observed in cell lines and late-stage MM, but the incidence of mutation in newly diagnosed patients
- Published
- 2003