44 results on '"Machado-Neto, João Agostinho"'
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2. Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia
3. Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3RT618I Cells
4. IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia
5. Potency and Efficacy of Pharmacological PIP4K2 Inhibitors in Acute Lymphoblastic Leukemia
6. Identification of Vulnerabilities for Pharmacological Inhibition of PIP4K2s in Acute Myeloid Leukemia
7. Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors
8. Cephalochromin-Induced Mitochondrial Damage Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia Models
9. Irs1S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality
10. IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia
11. Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell
12. Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome
13. Clinical Impact and Therapeutic Opportunity of Insulin Receptor Substrates 1/2 in Acute Myeloid Leukemia
14. Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2V617F Cells
15. Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1T315I mutant Cells
16. Multitarget Antileukemic Effects of Metformin in Myeloproliferative Neoplasm Cells: Inhibition of JAK2/STAT Signaling and Mitochondrial Activity
17. Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1A Expression in Acute Lymphoblastic Leukemia Cells
18. Pharmacological IRS1/2 Inhibition Reduces Cell Viability in BCR-ABL1 Positive Cells
19. Antisense Long Non-Coding RNA in the LEF1 Locus Regulates Sense LEF1 Expression in Leukemic Cell Line KG1
20. ARHGAP21 Is Upregulated and Triggers the Modulation of Rho Gtpase Signaling Pathways during Megakaryocytic Differentiation
21. Metformin Reduces Tumor Burden and Splenomegaly in JAK2V617F Murine Models
22. DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients
23. IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia
24. Stathmin 1 Is Highly Expressed in Acute Promyelocytic Leukemia and Microtubule Dynamics Is a Potential Target for ATRA-Resistant APL Cells
25. Long Non-Coding Transcript in LEF1 Locus Is a Novel Regulator of Cell Cycle and Apoptotic Pathways in Myeloid Leukemic Cells
26. The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms
27. Nix (BNIP3L) Is Downregulated in High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia and Its Silencing Enhances Decitabine-Mediated Apoptosis
28. IRS2 Inhibition Reduces Cell Proliferation and Has Cumulative Effects with Ruxolitinib in JAK2 V617F Cells
29. Stathmin 1 Silencing Amplifies Ruxolitinib-Induced Apoptosis in JAK2V617F Cells
30. Cellular and Molecular Effects of NVP-BKM120 in Lymphoblastic Leukemia Cells
31. Hematopoietic Cell Kinase (HCK) Is Involved in Myelodysplastic Syndromes and Acute Leukemia Pathophysiology By Modulating PI3K Pathway and Enhancing Erythroid Differentiation
32. Downregulation Of SPINT2 Expression In Stromal Cells From Myelodysplastic Syndrome Patients Increases HGF and SDF-1 Secretion and Promotes Cell-Cell Adhesion By Alteration In Integrin Expression
33. Stathmin 1 Is Involved In The Highly Proliferative Phenotype Of High-Risk Myelodysplastic Syndromes and Acute Leukemia Cells
34. ANKHD1 Silencing Reduces In Vitro Clonogenicity and In Vivo Tumorogenicity Of Multiple Myeloma Cells
35. FMNL1 Is Downregulated In Myelodysplastic Syndromes and Is Involved In Megakaryocytic Differentiation
36. VASP Protein, a Binding Partner Of BCR-ABL and FAK, May Be Implicated In The Chronic Myeloid Leukemia Phenotype
37. Familial Mastocytosis: Identification Of KIT K509I Mutation and Its In Vitro Sensitivity To Imatinib, Dasatinib and PKC412
38. Irs1S57XHeterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality
39. DNMT3AIs Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients
40. Pharmacological IRS1/2 Inhibition Induces Apoptosis in BCR-ABL1T315Imutant Cells
41. Pharmacological IGF1R/IRS Inhibitor, NT157, Effectively Induces Apoptosis and CDKN1AExpression in Acute Lymphoblastic Leukemia Cells
42. IRS2Inhibition Reduces Cell Proliferation and Has Cumulative Effects with Ruxolitinib in JAK2V617F Cells
43. Familial Mastocytosis: Identification Of KIT K509I Mutation and Its In VitroSensitivity To Imatinib, Dasatinib and PKC412
44. ANKHD1 Silencing Reduces In VitroClonogenicity and In VivoTumorogenicity Of Multiple Myeloma Cells
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