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Your search keyword '"Malec, Lynn M."' showing total 21 results
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21 results on '"Malec, Lynn M."'

4. Hemophilia Natural History Study (ATHN 7): Baseline Characteristics, Adverse Events, and Self-Reported Health Status of Individuals with Hemophilia a and B

Author

Buckner, Tyler W., primary, Carpenter, Shannon L, additional, Croteau, Stacy E., additional, Cuker, Adam, additional, Daoud, Nabil, additional, Kempton, Christine L, additional, Malec, Lynn M, additional, McLean, Thomas W., additional, Raffini, Leslie J., additional, Staber, Janice M, additional, Wang, Michael, additional, Watson, Crystal, additional, Zia, Ayesha, additional, and Recht, Michael, additional

Published
2020
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5. Inhibit Clinical Trials Platform to Prevent and Eradicate Inhibitors: Feasibility Survey of Current Prophylaxis and Immune Tolerance Practices

Author

Ragni, Margaret V., primary, Xavier, Frederico, additional, Seaman, Craig D., additional, Acharya, Suchitra, additional, McGuinn, Catherine E., additional, Werner, Eric J., additional, Lawrence, Courtney Elizabeth, additional, Wheeler, Allison P., additional, Reiss, Ulrike, additional, Ayala, Irmel, additional, Cockrell, Erin, additional, Tarango, Cristina, additional, Dunn, Amy, additional, Kulkarni, Roshni, additional, Ahuja, Sanjay P, additional, Chitlur, Meera B., additional, Pipe, Steven W., additional, Malec, Lynn M, additional, Rodriguez, Vilmarie, additional, Crary, Shelley, additional, Brown, Deborah, additional, Diaz, Rosa, additional, Velez, Maria, additional, Leissinger, Cindy A., additional, Carpenter, Shannon L, additional, Knoll, Christine M., additional, Wang, Michael, additional, Young, Guy, additional, Thornburg, Courtney D, additional, Lasky, Joseph L, additional, Lucas, Tiffany Lin, additional, Hwang, Nina, additional, Vehec, Deborah, additional, Ivanco, Dana, additional, Haller, Tamara L., additional, Bertolet, Marnie, additional, and Brooks, Maria M, additional

Published
2020
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6. U.S. Cohort Study of Previously Untreated Patients with Congenital Hemophilia (ATHN 8: PUPs Study): Association between Family History and Age of Diagnosis

Author

Thornburg, Courtney D, primary, Friedman, Kenneth D, additional, Guerrera, Michael F, additional, He, Chunla, additional, Malec, Lynn M, additional, Simpson, Mindy L, additional, Tarantino, Michael D, additional, Van Den Berg, H. Marijke, additional, Watson, Crystal, additional, and Carpenter, Shannon L, additional

Published
2020
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9. Von Willebrand Disease Minimize Menorrhagia (VWDMin) Trial

Author

Ragni, Margaret V., primary, Seaman, Craig D., additional, Gilligan, Diana, additional, Philipp, Claire S., additional, Neff, Anne T., additional, Sidonio, Robert F., additional, Kuriakose, Philip, additional, Wang, Tzu-Fei, additional, Malec, Lynn M., additional, Pruthi, Rajiv K., additional, Majerus, Elaine, additional, Rodgers, George M., additional, Nance, Danielle, additional, Hwang, Nina, additional, Konkle, Barbara A., additional, Leavitt, Andrew D., additional, Lasky, Joseph, additional, Wheeler, Allison P., additional, Kulkarni, Roshni, additional, Singleton, Tammuella, additional, Ivanco, Dana, additional, Youm, Elynna, additional, Koerbel, Glory, additional, Rothenberger, Scott, additional, and Rubio, Doris M., additional

Published
2019
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12. Von Willebrand Factor to Prevent Postpartum Hemorrhage

Author

Machin, Nicoletta, primary, Ragni, Margaret V., additional, James, Andra H., additional, Seaman, Craig D., additional, Malec, Lynn M., additional, Kessler, Craig M., additional, Konkle, Barbara, additional, Kouides, Peter, additional, Neff, Anne T., additional, Philipp, Claire S., additional, and Brooks, Maria M., additional

Published
2016
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15. Von Willebrand Factor for Menorrhagia: A Survey and Literature Review

Author

Machin, Nicoletta, primary, Ragni, Margaret V., additional, Malec, Lynn M., additional, Brambilla, Donald, additional, Coyle, Thomas, additional, Davis, Joanna A., additional, Drygalski, Annette, additional, James, Andra H, additional, Jobe, Shawn M, additional, Konkle, Barbara A., additional, Kouides, Peter, additional, Kuriakose, Philip, additional, Ma, Alice D., additional, Majerus, Elaine M., additional, Nance, Danielle, additional, Neff, Anne T., additional, Philipp, Claire S., additional, Wang, Tzu-Fei, additional, and Yaish, Hassan M., additional

Published
2015
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19. Validation Study Of The Composite Score To Identify Von Willebrand Disease in Children

Author

Malec, Lynn M., primary, Moore, Charity G., additional, Bennett, Carolyn M., additional, Yee, Donald L, additional, Kerlin, Bryce A., additional, Witmer, Char, additional, Gunawardena, Sriya, additional, Kulkarni, Roshni, additional, Gupta, Sweta, additional, Kouides, Peter A., additional, Brown, Deborah, additional, Bujnicki, Heather L., additional, and Ragni, Margaret V., additional

Published
2013
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20. Observational Study of Recombinant Factor-VIII-Fc, Eloctate, in Hemophilia Patients with and without Inhibitors

Author

Ebbert, Patrick T., Ragni, Margaret V., Xavier, Frederico, Malec, Lynn M., and Seaman, Craig D.

Abstract

Background:Inhibitor formation is a serious complication of hemophilia A, occurring in up to 30% with severe disease. It is associated with a T-cell response to infused factor VIII which neutralizes and renders it ineffective. Bypass therapy (rVIIa, FEIBA) is less effective, resulting in high morbidity and mortality. While immune tolerance (ITI) with high-dose FVIII neutralizes the inhibitor, it is costly, invasive, and unsuccessful in 30%. Basic studies suggest rFVIIIFc, Eloctate,is less immunogenic than standard recombinant FVIII, rFVIII, as the Fc portion contains regulatory T cells that promote tolerance. In the hemophilia mouse model, rFVIIIFc reduces inhibitor frequency, lowers titer, and shortens ITI, but little is known of its impact on inhibitor patients, as they were excluded from clinical trials.

Published
2017
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21. Copper Deficiency

Author

Close, Allison and Malec, Lynn M.

Abstract

BACKGROUND:Acquired copper deficiency in the pediatric population is a rare event but given the hematologic and potentially irreversible neurologic consequences, prompt recognition and treatment is important. Copper is an essential cofactor in enzymatic reactions essential to proper hematologic, skeletal, neurologic and vascular function. Copper is found in a variety of foods including meats, nuts, legumes, and whole grains while lacking in highly processed foods. Copper requirements in children over the age of 4 is 15 mg/day, which is readily acquired in a typical diet. Copper deficiency is known to occur in patients with the rare X-linked mutation in the ATP7A copper transport protein, known as Menkes Syndrome, and in older individuals with gastrointestinal bypass surgery who lose the ability to absorb copper through the duodenum and proximal jejunum, however, it is rarely reported in other conditions. Pediatric patients with autism spectrum disorders or developmental delay with a limited dietary repertoire are at risk for copper deficiency thus a high index of suspicion must exist in order to diagnose the disorder.

Published
2017
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