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1,194 results on '"Malik, A"'

1. An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections

Author

Akhtar, Shaheen, Anwar, Mohammad, Arciero, Elena, Asgar, Omar, Ashraf, Samina, Bidi, Saeed, Breen, Gerome, Broster, James, Chaudhary, Shabana, Chung, Raymond, Clinch, Megan, Collier, David, Colligan, Grainne, Curtis, Charles J., Deloukas, Panos, Durham, Ceri, Durrani, Faiza, Eto, Fabiola, Finer, Sarah, Gafton, Joseph, Angel Garcia, Ana Cristina, Griffiths, Chris, Harvey, Joanne, van Heel, David A., Heng, Teng, Hodgson, Sam, Huang, Qin Qin, Hurles, Matt, Hunt, Karen A, Hussain, Shapna, Islam, Kamrul, Iyer, Vivek, Jacobs, Benjamin M., Khan, Ahsan, Langenberg, Claudia, Lavery, Cath, Lee, Sang Hyuck, MacArthur, Daniel, Malik, Sidra, Malawsky, Daniel, Martin, Hilary, Mason, Dan, Mathur, Rohini, Mazid, Mohammed Bodrul, McDermott, John, Morton, Caroline, Newman, Bill, Owor, Elizabeth, Qureshi, Asma, Ramachandrappa, Shwetha, Raza, Mehru, Russell, Jessry, Safa, Nishat, Samuel, Miriam, Simpson, Michael, Solly, John, Spreckley, Marie, Stow, Daniel, Taylor, Michael, Trembath, Richard C., Tricker, Karen, Walter, Klaudia, Winckley, Caroline, Wood, Suzanne, Wright, John, Zengeya, Ishevanhu, Zöllner, Julia, Gomez, Esteban A., De Matteis, Roberta, Udomjarumanee, Palita, Munroe, Patricia B., and Dalli, Jesmond

Published
2024
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2. Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML

Author

Hassan, Nunki, Yi, Hangyu, Malik, Bilal, Gaspard-Boulinc, Lucie, Samaraweera, Saumya E., Casolari, Debora A., Seneviratne, Janith, Balachandran, Anushree, Chew, Tracy, Duly, Alastair, Carter, Daniel R., Cheung, Belamy B., Norris, Murray, Haber, Michelle, Kavallaris, Maria, Marshall, Glenn M., Zhang, Xu Dong, Liu, Tao, Wang, Jianlong, Liebermann, Dan A., D’Andrea, Richard J., and Wang, Jenny Y.

Published
2024
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3. The role of CD8+ T-cell clones in immune thrombocytopenia

Author

Malik, Amna, Sayed, Anwar A., Han, Panpan, Tan, Michelle M. H., Watt, Eleanor, Constantinescu-Bercu, Adela, Cocker, Alexander T. H., Khoder, Ahmad, Saputil, Rocel C., Thorley, Emma, Teklemichael, Ariam, Ding, Yunchuan, Hart, Alice C. J., Zhang, Haiyu, Mitchell, Wayne A., Imami, Nesrina, Crawley, James T. B., Salles-Crawley, Isabelle I., Bussel, James B., Zehnder, James L., Adams, Stuart, Zhang, Bing M., and Cooper, Nichola

Published
2023
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5. Impact of Multiple Minor Histocompatibility Antigen Differences on Graft-Versus-Host Disease and Relapse Risk in Pediatric Allogeneic Hematopoietic Cell Transplantation Recipients

Author

Mueller, Christian, primary, Alawi, Malik, additional, Loeffler, Juergen, additional, Bonin, Michael, additional, Schreiber, Andreas, additional, Kreyenberg, Hermann, additional, Wiegering, Verena, additional, Woelfl, Matthias, additional, Caruana, Ignazio, additional, Schlegel, Paul G., additional, and Eyrich, Matthias, additional

Published
2023
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6. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

Author

Han, Jingyan, Zhang, Guoying, Welch, Emily J, Liang, Ying, Fu, Jian, Vogel, Stephen M, Lowell, Clifford A, Du, Xiaoping, Cheresh, David A, Malik, Asrar B, and Li, Zhenyu

Subjects
Hematology, Infectious Diseases, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Cardiovascular, Adherens Junctions, Animals, Capillary Permeability, Down-Regulation, Endothelial Cells, Endothelium, Vascular, Focal Adhesion Kinase 1, Human Umbilical Vein Endothelial Cells, Humans, Lipopolysaccharides, Mice, Mice, Knockout, Phosphorylation, src-Family Kinases, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology
Abstract

The Src family kinases (SFKs) c-Src and Yes mediate vascular leakage in response to various stimuli including lipopolysaccharide (LPS) and vascular endothelial growth factor (VEGF). Here, we define an opposing function of another SFK, Lyn, which in contrast to other SFKs, strengthens endothelial junctions and thereby restrains the increase in vascular permeability. Mice lacking Lyn displayed increased mortality in LPS-induced endotoxemia and increased vascular permeability in response to LPS or VEGF challenge compared with wild-type littermates. Lyn knockout mice repopulated with wild-type bone marrow-derived cells have higher vascular permeability than wild-type mice, suggesting a role of endothelial Lyn in the maintenance of the vascular barrier. Small interfering RNA-mediated down-regulation of Lyn disrupted endothelial barrier integrity, whereas expression of a constitutively active mutant of Lyn enhanced the barrier. However, down-regulation of Lyn did not affect LPS-induced endothelial permeability. We demonstrate that Lyn association with focal adhesion kinase (FAK) and phosphorylation of FAK at tyrosine residues 576/577 and 925 were required for Lyn-dependent stabilization of endothelial adherens junctions. Thus, in contrast to c-Src and Yes, which increase vascular permeability in response to stimuli, Lyn stabilizes endothelial junctions through phosphorylation of FAK. Therefore, therapeutics activating Lyn kinase may strengthen the endothelial barrier junction and hence have anti-inflammatory potential.

Published
2013

11. Universal Updated Phase 1 Data Highlights Role of Allogeneic Anti-BCMA ALLO-715 Therapy for Relapsed/Refractory Multiple Myeloma

Author

Sham Mailankody, Jeffrey V. Matous, Michaela Liedtke, Surbhi Sidana, Olalekan O. Oluwole, Meera Mohan, Jose C. Cruz, Rajneesh Nath, Faiz Anwer, Adriana Rossi, Myo Htut, Shahbaz A. Malik, Srinivas Ghatta, Myles Dillon, Wendy Ying, Lynn Navale, Erin E. Karski, Arun Balakumaran, and Shaji K. Kumar

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

13. A transplant “immunome” screening platform defines a targetable epitope fingerprint of multiple myeloma

Author

Schieferdecker, Aneta, Oberle, Anna, Thiele, Benjamin, Hofmann, Fabian, Göthel, Markus, Miethe, Sebastian, Hust, Michael, Braig, Friederike, Voigt, Mareike, von Pein, Ute-Marie, Koch-Nolte, Friedrich, Haag, Friedrich, Alawi, Malik, Indenbirken, Daniela, Grundhoff, Adam, Bokemeyer, Carsten, Bacher, Ulrike, Kröger, Nicolaus, and Binder, Mascha

Published
2016
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15. The role of CD8+ T cell clones in immune thrombocytopenia

Author

Amna Malik, Anwar A. Sayed, Panpan Han, Michelle M.H. Tan, Eleanor Watt, Adela Constantinescu-Bercu, Alexander T.H. Cocker, Ahmad Khoder, Rocel Christine Saputil, Emma V. Thorley, Ariam Teklemichael, Yunchuan Ding, Alice C.J. Hart, Haiyu Zhang, Wayne A. Mitchell, Nesrina Imami, James T.B. Crawley, Isabelle I. Salles-Crawley, James B. Bussel, James L. Zehnder, Stuart Paul Adams, Bing M. Zhang, and Nichola Cooper

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Abstract

Immune thrombocytopenia (ITP) is traditionally considered an antibody-mediated disease. However, a number of features suggest alternative mechanisms of platelet destruction. In this study, we use a multi-dimensional approach to explore the role of cytotoxic CD8+ T cells in ITP. We characterised patients with ITP and compared them to age-matched controls using immunophenotyping, next-generation sequencing of T cell receptor (TCR) genes, single-cell RNA sequencing, and functional T cell and platelet assays. We found that adults with chronic ITP have increased polyfunctional, terminally differentiated effector memory CD8+ T cells (CD45RA+CD62L-) expressing intracellular interferon-g, tumour necrosis factor-a, and Granzyme B defining them as TEMRA cells. These TEMRA cells expand when the platelet count falls and show no evidence of physiological exhaustion. Deep sequencing of the T cell receptor showed expanded T cell clones in patients with ITP. T cell clones persisted over many years, were more prominent in patients with refractory disease, and expanded when the platelet count was low. Combined single-cell RNA and TCR sequencing of CD8+ T cells confirmed that the expanded clones are TEMRA cells. Using in vitro model systems, we show that CD8+ T cells from patients with ITP form aggregates with autologous platelets, release interferon-g and trigger platelet activation and apoptosis through TCR-mediated release of cytotoxic granules. These findings of clonally expanded CD8+ T cells causing platelet activation and apoptosis provide an antibody-independent mechanism of platelet destruction, indicating that targeting specific T-cell clones could be a novel therapeutic approach for patients with refractory ITP.

Published
2023

16. Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia

Author

Omar Niss, Jon Detterich, John C. Wood, Thomas D. Coates, Punam Malik, Michael D. Taylor, and Charles T. Quinn

Subjects
Myocardium, Immunology, Humans, Anemia, Sickle Cell, Cell Biology, Hematology, Cardiomyopathies, Fibrosis, Biochemistry
Abstract

Cardiovascular disease is a major cause of mortality in patients with sickle cell disease (SCD). Niss et al previously reported that cardiac magnetic resonance in 25 patients showed universal myocardial fibrosis, which they correlated with increased extracellular volume fraction (ECV). In the current study, they compared patients with SCD who were treated with hydroxyurea or transfusion at age

Published
2022

19. BCMA-Targeted, Hypoimmune Allogeneic CAR T Cells Exhibit Potent Anti-Tumor Activity Together with the Ability to Evade Innate and Adaptive Immune Rejection in Pre-Clinical Tumor Models

Author

Kinder, Jeremy M., primary, Athena-Estrada, Chanel, additional, Malik, Danyal, additional, Hu, Xiaomeng, additional, Lamba, Meghan, additional, Young, Chi, additional, Van Hoeven, Neal, additional, Granger, Brian, additional, Chaturvedi, Vandana, additional, Liang, Ouwen, additional, Moreno, Jesus, additional, Lampano, Aaron, additional, Zipp, Garrett, additional, Johnson, Adam, additional, Fry, Terry, additional, Schrepfer, Sonja, additional, and Foster, Aaron, additional

Published
2022
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20. CD8+ TEMRA Clones Cause Platelet Lysis in Immune Thrombocytopenia

Author

Malik, Amna, primary, Tan, Michelle MH, additional, Sayed, Anwar A, additional, Han, Panpan, additional, Watt, Eleanor, additional, Constantinescu-Bercu, Adela, additional, Khoder, Ahmad, additional, Cocker, Alexander TH, additional, Thorley, Emma, additional, Teklemichael, Ariam, additional, Ding, Yunchuan, additional, Saputil, Rocel C., additional, Hart, Alice C J, additional, Zhang, Haiyu, additional, Mitchell, Wayne A., additional, Imami, Nesrina, additional, Crawley, James TB, additional, Salles-Crawley, Isabelle, additional, Bussel, James B., additional, Zehnder, James L, additional, Adams, Stuart, additional, Zhang, Bing Melody, additional, and Cooper, Nichola, additional

Published
2022
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21. Characterisation of Platelet Sensitivity in Immune Thrombocytopenia Identifies Distinct Subgroups with Either Higher or Lower Platelet Sensitivity

Author

Saputil, Rocel C., primary, Dunster, Joanne L., additional, Kriek, Neline, additional, Ding, Yunchuan, additional, Bhide, Anuradha, additional, Hart, Alice C J, additional, Tan, Michelle MH, additional, Thorley, Emma, additional, Teklemichael, Ariam, additional, Mitchell, Wayne A., additional, Malik, Amna, additional, Gibbins, Jonathan M., additional, and Cooper, Nichola, additional

Published
2022
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22. Universal Updated Phase 1 Data Highlights Role of Allogeneic Anti-BCMA ALLO-715 Therapy for Relapsed/Refractory Multiple Myeloma

Author

Mailankody, Sham, primary, Matous, Jeffrey V., additional, Liedtke, Michaela, additional, Sidana, Surbhi, additional, Oluwole, Olalekan O., additional, Mohan, Meera, additional, Cruz, Jose C., additional, Nath, Rajneesh, additional, Anwer, Faiz, additional, Rossi, Adriana, additional, Htut, Myo, additional, Malik, Shahbaz A., additional, Ghatta, Srinivas, additional, Dillon, Myles, additional, Ying, Wendy, additional, Navale, Lynn, additional, Karski, Erin E., additional, Balakumaran, Arun, additional, and Kumar, Shaji K., additional

Published
2022
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24. Safety and Efficacy of SARS-CoV-2 Vaccination in Patients with Immune Thrombocytopaenia: a Multi-Centre Review

Author

Stefani, Sara, primary, Saputil, Rocel C., additional, Tan, Michelle MH, additional, Buti, Noora, additional, Paul, Deena, additional, Rizvi, Naghma, additional, Ragoonanan, Vashti, additional, Thorley, Emma, additional, Teklemichael, Ariam, additional, Vladescu, Camelia, additional, Malik, Amna, additional, Ademokun, Christine, additional, Hart, Alice C J, additional, Szydlo, Richard, additional, Adams, George, additional, Bussel, James B., additional, Jansen, A.J. Gerard, additional, and Cooper, Nichola, additional

Published
2022
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25. Characterisation of Platelet Sensitivity in Severe COVID-19

Author

Saputil, Rocel C., primary, Dunster, Joanne L., additional, Kriek, Neline, additional, Ding, Yunchuan, additional, Tan, Michelle M.H., additional, Thorley, Emma, additional, Pillay, Clio, additional, Charania, Asad, additional, Dominguez-Villar, Margarita, additional, Mitchell, Wayne A., additional, Malik, Amna, additional, Gibbins, Jonathan M., additional, and Cooper, Nichola, additional

Published
2022
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26. Do Children with Immune Thrombocytopenia Have Cerebral Microbleeds?

Author

Hart, Alice C J, primary, Cabrera, Ana Maria, additional, Vladescu, Camelia, additional, Mustafa, Sobia, additional, Syzdlo, Richard, additional, Saputil, Rocel C., additional, Tan, Michelle MH, additional, Malik, Amna, additional, Sharp, David, additional, Vicente, Pedro, additional, Busza, Albert, additional, Laffan, Michael, additional, Gontsarova, Anastasia, additional, Waldman, Adam, additional, and Cooper, Nichola, additional

Published
2022
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27. CRISPR/CAS9 Gene Editing of MIR155HG in Primary Human T Cells to Prevent Acute Graft-Versus-Host Disease

Author

Khanal, Shrijan, primary, Neidemire-Colley, Lotus, additional, Braunreiter, Kara M, additional, Snyder, Katiri, additional, Gao, Yandi, additional, Kalyan, Sonu, additional, Naeimi Kararoudi, Meisam, additional, Duszynski, Molly Erin, additional, Chi, Mengna, additional, Malik, Punam, additional, Choe, Hannah, additional, Garzon, Ramiro, additional, and Ranganathan, Parvathi, additional

Published
2022
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28. Choosing Wisely Ten Years on: Inpatient Thrombophilia Testing

Author

Kovalenko, Iuliia, primary, Golubykh, Konstantin, additional, Cuevas, Martin, additional, Ammari, Nadim, additional, Malik, Maidah, additional, Sandhu, Manpreet, additional, Qurashi, Hafiz, additional, Saleem, Tabinda, additional, Komanduri, Saketram, additional, Wert, Yijin, additional, and Lu, Kit, additional

Published
2022
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30. Eltrombopag Causes Cell Cycle Arrest of T Cells through Iron Chelation and Could Modulate the Immune Response in ITP

Author

Tan, Michelle MH, primary, Malik, Amna, additional, Sayed, Anwar A, additional, Saputil, Rocel C., additional, Zafar, Sara, additional, Ding, Yunchuan, additional, Thorley, Emma, additional, Teklemichael, Ariam, additional, Vladescu, Camelia, additional, Hart, Alice C J, additional, Ademokun, Christine, additional, Paul, Deena, additional, Rizvi, Naghma, additional, Ragoonanan, Vashti, additional, and Cooper, Nichola, additional

Published
2022
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32. Prevalence of Cancer & Cancer Subtypes and Association with Benzene, Toluene, Ethylbenzene, and Xylene - a Study from the National Health and Nutrition Survey

Author

Chowdhary, Arsh, primary, Bapat, Prachi, additional, Dawoodi, Inshiya, additional, Alkhatib, Lean, additional, Varma, Samyukta, additional, Antonella Velez Diaz, Lorena, additional, Poursina, Olia, additional, Centeno, Lisa, additional, Hashim, Tehmina, additional, Pan, Hai, additional, Malik, Preeti, additional, Patel, Urvish, additional, Kalra, Kartik, additional, Palabindela, Prasannalaxmi, additional, Patil, Ashish, additional, and Kukreja, Geetika, additional

Published
2022
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34. Do Children with Immune Thrombocytopenia Have Cerebral Microbleeds?

Author

Alice C J Hart, Ana Maria Cabrera, Camelia Vladescu, Sobia Mustafa, Richard Syzdlo, Rocel C. Saputil, Michelle MH Tan, Amna Malik, David Sharp, Pedro Vicente, Albert Busza, Michael Laffan, Anastasia Gontsarova, Adam Waldman, and Nichola Cooper

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

35. BCMA-Targeted, Hypoimmune Allogeneic CAR T Cells Exhibit Potent Anti-Tumor Activity Together with the Ability to Evade Innate and Adaptive Immune Rejection in Pre-Clinical Tumor Models

Author

Jeremy M. Kinder, Chanel Athena-Estrada, Danyal Malik, Xiaomeng Hu, Meghan Lamba, Chi Young, Neal Van Hoeven, Brian Granger, Vandana Chaturvedi, Ouwen Liang, Jesus Moreno, Aaron Lampano, Garrett Zipp, Adam Johnson, Terry Fry, Sonja Schrepfer, and Aaron Foster

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

37. Prevalence of Cancer & Cancer Subtypes and Association with Benzene, Toluene, Ethylbenzene, and Xylene - a Study from the National Health and Nutrition Survey

Author

Arsh Chowdhary, Prachi Bapat, Inshiya Dawoodi, Lean Alkhatib, Samyukta Varma, Lorena Antonella Velez Diaz, Olia Poursina, Lisa Centeno, Tehmina Hashim, Hai Pan, Preeti Malik, Urvish Patel, Kartik Kalra, Prasannalaxmi Palabindela, Ashish Patil, and Geetika Kukreja

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

40. Characterisation of Platelet Sensitivity in Severe COVID-19

Author

Rocel C. Saputil, Joanne L. Dunster, Neline Kriek, Yunchuan Ding, Michelle M.H. Tan, Emma Thorley, Clio Pillay, Asad Charania, Margarita Dominguez-Villar, Wayne A. Mitchell, Amna Malik, Jonathan M. Gibbins, and Nichola Cooper

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

49. Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Author

Rossi, Marianna, primary, Meggendorfer, Manja, additional, Zampini, Matteo, additional, Tettamanti, Mauro, additional, Riva, Emma, additional, Travaglino, Erica, additional, Bersanelli, Matteo, additional, Mandelli, Sara, additional, Antonella Galbussera, Alessia, additional, Mosca, Ettore, additional, Saba, Elena, additional, Chiereghin, Chiara, additional, Manes, Nicla, additional, Milanesi, Chiara, additional, Ubezio, Marta, additional, Morabito, Lucio, additional, Peano, Clelia, additional, Soldà, Giulia, additional, Asselta, Rosanna, additional, Duga, Stefano, additional, Selmi, Carlo, additional, De Santis, Maria, additional, Malik, Karolina, additional, Maggioni, Giulia, additional, Bicchieri, Marilena, additional, Campagna, Alessia, additional, Tentori, Cristina A., additional, Russo, Antonio, additional, Civilini, Efrem, additional, Allavena, Paola, additional, Piazza, Rocco, additional, Corrao, Giovanni, additional, Sala, Claudia, additional, Termanini, Alberto, additional, Giordano, Laura, additional, Detoma, Paolo, additional, Malabaila, Aurelio, additional, Sala, Luca, additional, Rosso, Stefano, additional, Zanetti, Roberto, additional, Saitta, Claudia, additional, Riva, Elena, additional, Condorelli, Gianluigi, additional, Passamonti, Francesco, additional, Santoro, Armando, additional, Sole, Francesc, additional, Platzbecker, Uwe, additional, Fenaux, Pierre, additional, Bolli, Niccolò, additional, Castellani, Gastone, additional, Kern, Wolfgang, additional, Vassiliou, George S., additional, Haferlach, Torsten, additional, Lucca, Ugo, additional, and Della Porta, Matteo G., additional

Published
2021
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50. Rates of Neutropenic Fever in Patients with Hematologic Malignant Diseases with Central Venous Access

Author

Abbagoni, Sujith, primary, Malik, Sarah, additional, Fox, Ashley D, additional, Mian, Mohammad A. H., additional, Anwar, Tahsin, additional, Bradshaw, Danielle, additional, Bryan, Locke J., additional, Jillella, Anand P, additional, Kolhe, Ravindra, additional, Savage, Natasha M., additional, Padala, Sandeep, additional, and Kota, Vamsi, additional

Published
2021
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