1. Type I natural killer T cells suppress tumors caused by p53 loss in mice.
- Author
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Swann JB, Uldrich AP, van Dommelen S, Sharkey J, Murray WK, Godfrey DI, and Smyth MJ
- Subjects
- Aging immunology, Animals, Antigens, CD1d genetics, Crosses, Genetic, Female, Genes, T-Cell Receptor alpha, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Natural Killer T-Cells classification, Neoplasms, Experimental genetics, Neoplastic Syndromes, Hereditary genetics, Specific Pathogen-Free Organisms, T-Lymphocyte Subsets classification, Tumor Burden, Gene Deletion, Genes, p53, Immunologic Surveillance, Natural Killer T-Cells immunology, Neoplasms, Experimental immunology, Neoplastic Syndromes, Hereditary immunology, T-Lymphocyte Subsets immunology
- Abstract
CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking either type I NKT cells (TCR Jalpha18(-/-)) or all CD1d-restricted T cells (CD1d(-/-)). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development.
- Published
- 2009
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