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1. Recurrent Mutations of the C-C Motif Chemokine Ligand 22 (CCL22) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

Author

Baer, Constance, primary, Kimura, Shunsuke, additional, Iacobucci, Ilaria, additional, Feith, David J, additional, Walter, Wencke, additional, Meggendorfer, Manja, additional, Olson, Thomas L., additional, Ratan, Aakrosh, additional, Müller, Martha-Lena, additional, Rana, Mitra, additional, Qu, Chunxu, additional, Kalathur, Ravi, additional, Haferlach, Claudia, additional, Kern, Wolfgang, additional, Loughran, Thomas P., additional, Mullighan, Charles G, additional, and Haferlach, Torsten, additional

Published
2020
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2. Recurrent Mutations of the C-C Motif Chemokine Ligand 22(CCL22) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK)

Author

Baer, Constance, Kimura, Shunsuke, Iacobucci, Ilaria, Feith, David J, Walter, Wencke, Meggendorfer, Manja, Olson, Thomas L., Ratan, Aakrosh, Müller, Martha-Lena, Rana, Mitra, Qu, Chunxu, Kalathur, Ravi, Haferlach, Claudia, Kern, Wolfgang, Loughran, Thomas P., Mullighan, Charles G, and Haferlach, Torsten

Abstract

Background:The pathogenesis of chronic lymphoproliferative disorder of NK-cells (CLPD-NK) is poorly understood. Mutations in the JAK/STAT pathway (especially STAT3) are found in 30% of patients, but the genetic or exogenous drivers responsible for other cases are unknown. Here we comprehensively define the genetic drivers of CLPD-NK by integrated genome and transcriptome sequencing (WGS/WTS) of a large cohort of cases and complementary functional analyses.

Published
2020
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