440 results on '"Rivella, Stefano"'
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2. Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis
3. Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia
4. Hepcidin agonists as therapeutic tools
5. Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin
6. Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome
7. Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice
8. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera
9. In Vivo Modification of Hematopoietic Stem Cells By Targeted Lipid Nanoparticles Encapsulating mRNA
10. Direct Delivery of mRNA-Loaded Lipid Nanoparticles to the Hematopoietic Stem Cell Niche
11. The Effect of Monoferric Transferrins on Hypoferremia in a Murine Model of Inflammation
12. Establishment of High Titer Baboon Endogenous Retrovirus Envelope Pseudotyped Lentiviral Vector Production Protocol Focusing on Syncytium Formation and Exfoliation
13. Differential Effects of Monoferric Forms of Transferrin on Mouse Models of Anemia of Inflammation and Congenital Anemia
14. Combination of a TGF-β Ligand Trap (RAP-GRL) and TMPRSS6-ASO Is Superior for Correcting β-Thalassemia
15. TNFα and Anti-IFNγ Rescues Chronic Anemia of Inflammation Phenotype in Tnfαko Mice Treated with Heat-Killed Brucella Abortus
16. Lnp-Targeting Hematopoietic Stem Cells and Lentiviral Gene Transfer to Generate and Rescue a Novel Mouse Model of Lethal Alpha-Thalassemia
17. Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus
18. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis
19. Tfr2 Genetic Deletion Makes Transfusion-Independent a Murine Model of Transfusion-Dependent β-Thalassemia
20. Rescue of Murine IL-7 Receptor Deficiency with Human IL-7 Receptor Gene Therapy
21. Lack of IL6 Improves Recovery from Anemia of Inflammation Which Gets Hampered in Presence of Excess Iron
22. Combination of a Luspatercept-like Drug (RAP-GRL) and Tmprss6-ASO Is Superior to Either Drug Alone for Correcting β-Thalassemia
23. A Severe Mouse Model of Alpha-Thalassemia to Study Abnormal Iron Metabolism and Erythropoiesis, Hematopoietic Stem Cell Behavior and Development of a Gene Therapy Approach for Its Treatment
24. TNFα Controls the Delicate Balance between Erythropoiesis and Stem Cell Exhaustion during Inflammatory Stress
25. Obligate N-Terminal but Not C-Terminal Monoferric Transferrin Ameliorates Anemia in β-Thalassemic Mice
26. Improved Gene Therapy for Metachromatic Leukodystrophy
27. Dietary Iron Increases Expression of Liver Hepcidin Relative to BMP6 By a Mechanism Involving Transferrin Receptor 2 and Specificity of Transferrin Lobe Iron Occupancy
28. Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia
29. Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation
30. Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia
31. Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity
32. Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies
33. 2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies
34. Elucidating the Role of IL6 in Stress Erythropoiesis and in the Development of Anemia Under Inflammatory Conditions
35. PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation
36. Erythroferrone Regulates Bone Remodeling in β-Thalassemia
37. Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study
38. Correcting Non-Transfusion Dependent β-Thalassemia by Utilizing a Combined Therapy that Modulates EPO Activity by Limiting Erythroid Cellular Iron Intake
39. Lack of GDF11 Does Not Ameliorate Erythropoiesis in β-Thalassemia and Does Not Prevent the Activity of the Trap-Ligand RAP-536
40. Improved Lentiviral Vectors for the Cure of Hemoglobinopathies
41. An Orchestrated Balance between Mitochondria Biogenesis, Iron-Sulfur Cluster Synthesis and Cellular Iron Acquisition
42. AMPK Regulates the Expression of the Fe-S Cluster Assembly Enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis
43. Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers
44. Administration of Minihepcidins to Animals Affected By β-Thalassemia Major Reduces Anemia and Splenomegaly
45. Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia
46. Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major
47. Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS
48. Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos
49. A Novel Dual Monoclonal Sandwich ELISA for Human Erythroferrone
50. Ex Vivo Gene Therapy Approach By Targt Technology for the Treatment of β-Thalassemia Intermedia
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