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11 results on '"Roux, Philippe"'

2. Identification of Novel Antigens for Normal Karyotype Triple Mutated Acute Myeloid Leukemia

Author

Metois, Arnaud, primary, Bordeleau, Marie-Eve, additional, Theret, Louis, additional, Hajmirza, Azadeh, additional, Moujaber, Ossama, additional, Spinella, Jean-François, additional, Chagraoui, Jalila, additional, Mayotte, Nadine, additional, Boivin, Isabel, additional, Audemard, Eric, additional, Farah, Azer, additional, Lisi, Véronique, additional, Bonneil, Eric, additional, Thibault, Pierre, additional, Richard-Carpentier, Guillaume, additional, Lavallée, Vincent-Philippe, additional, Hebert, Josee, additional, Roux, Philippe P, additional, and Sauvageau, Guy, additional

Published
2022
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3. Identification of Novel Cell Surface Therapeutic Targets for KMT2A-Rearranged Acute Myeloid Leukemia

Author

Theret, Louis, primary, Bordeleau, Marie-Eve, additional, Hajmirza, Azadeh, additional, Metois, Arnaud, additional, Moujaber, Ossama, additional, Audemard, Eric, additional, Spinella, Jean-Francois, additional, Chagraoui, Jalila, additional, Aubert, Léo, additional, Farah, Azer, additional, Lisi, Véronique, additional, Bonneil, Eric, additional, Boivin, Isabel, additional, Mayotte, Nadine, additional, MacRae, Tara, additional, Thibault, Pierre, additional, Lemieux, Sébastien, additional, Lavallée, Vincent-Philippe, additional, Hebert, Josee, additional, Sauvageau, Guy, additional, and Roux, Philippe P, additional

Published
2022
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4. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia

Author

Baccelli, Irene, primary, Gareau, Yves, additional, Lehnertz, Bernhard, additional, Stephane, Gingras, additional, Spinella, Jean-Francois, additional, Beautrait, Alexandre, additional, Corneau, Sophie, additional, Mayotte, Nadine, additional, Boivin, Isabel, additional, Girard, Simon, additional, MacRae, Tara, additional, Frechette, Melanie, additional, Leveille, Koryne, additional, Krosl, Jana, additional, Thiollier, Clarisse, additional, Kanshin, Evgeny, additional, Bertomeu, Thierry, additional, Coulombe-Huntington, Jasmin, additional, St-Denis, Corinne, additional, Bordeleau, Marie-Eve, additional, Boucher, Geneviève, additional, Roux, Philippe P, additional, Lemieux, Sébastien, additional, Tyers, Mike, additional, Thibault, Pierre, additional, Marinier, Anne, additional, Hébert, Josée, additional, and Sauvageau, Guy, additional

Published
2018
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5. Germline GAB2 Mutations in Childhood Acute Lymphoblastic Leukemia

Author

de Smith, Adam J, primary, Lavoie, Geneviève, additional, Walsh, Kyle M, additional, Aujla, Sumeet, additional, Evans, Erica, additional, Hansen, Helen M, additional, Smirnov, Ivan, additional, Kang, Alice Y, additional, Zenker, Martin, additional, Ceremsak, John J, additional, Stieglitz, Elliot, additional, McKean-Cowdin, Roberta, additional, Metayer, Catherine, additional, Roux, Philippe P, additional, and Wiemels, Joseph L, additional

Published
2018
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7. Targeting Pre-Leukemic Stem Cells in T-Acute Lymphoblastic Leukemia

Author

Gerby, Bastien, primary, Veiga, Diogo F.T, additional, Krosl, Jana, additional, Ouellette, Julianne, additional, Haman, André, additional, Lavoie, Geneviève, additional, Fares, Iman, additional, Tremblay, Mathieu, additional, Litalien, Véronique, additional, Ottoni, Elizabeth, additional, Kosic, Milena, additional, Geoffrion, Dominique, additional, Ryan, Joël, additional, Maddox, Paul, additional, Chagraoui, Jalila, additional, Marinier, Anne, additional, Hébert, Josée, additional, Sauvageau, Guy, additional, Kwok, Benjamin H, additional, Roux, Philippe P, additional, and Hoang, Trang, additional

Published
2016
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8. Identification of Acute Myeloid Leukemia Cell Surface Therapeutic Targets Using Single Cell RNA Sequencing Supported By Surface Proteomics

Author

Lisi, Véronique, Khakipoor, Banafsheh, Farah, Azer, Bordeleau, Marie-Eve, Audemard, Eric, Metois, Arnaud, Theret, Louis, Spinella, Jean-François, Chagraoui, Jalila, Moujaber, Ossama, Mallinger, Laure, Boivin, Isabel, Mayotte, Nadine, Hajmirza, Azadeh, Bonneil, Eric, Béliveau, Francois, Feghali, Albert, Boucher, Geneviève, Gendron, Patrick, Barabe, Frederic, Lemieux, Sebastien, Richard-Carpentier, Guillaume, Hébert, Josée, Roux, Philippe, Sauvageau, Guy, and Lavallee, Vincent-Philippe

Abstract

Background:

Published
2023
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9. EPCR expression marks UM171-expanded CD34+cord blood stem cells

Author

Fares, Iman, Chagraoui, Jalila, Lehnertz, Bernhard, MacRae, Tara, Mayotte, Nadine, Tomellini, Elisa, Aubert, Léo, Roux, Philippe P., and Sauvageau, Guy

Abstract

A small subset of human cord blood CD34+cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171. In this article, we show that EPCR-positive UM171-treated cells, as opposed to EPCR-negative cells, exhibit robust multilineage repopulation and serial reconstitution ability in immunocompromised mice. In contrast to other stem cell markers, such as CD38, EPCR expression is maintained when cells are introduced in culture, irrespective of UM171 treatment. Although engineered overexpression of EPCR fails to reproduce the effects of UM171 on HSC activity, its expression is required for the repopulating activity of human HSCs. Altogether, our results indicate that EPCR is a reliable and cell culture–compatible marker of UM171-expanded human cord blood HSCs.

Published
2017
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10. Germline GAB2Mutations in Childhood Acute Lymphoblastic Leukemia

Author

de Smith, Adam J, Lavoie, Geneviève, Walsh, Kyle M, Aujla, Sumeet, Evans, Erica, Hansen, Helen M, Smirnov, Ivan, Kang, Alice Y, Zenker, Martin, Ceremsak, John J, Stieglitz, Elliot, McKean-Cowdin, Roberta, Metayer, Catherine, Roux, Philippe P, and Wiemels, Joseph L

Abstract

Recent studies using next-generation sequencing of selected individuals, such as those with familial leukemia or congenital syndromes, have identified rare and highly penetrant germline mutations that predispose to childhood acute lymphoblastic leukemia (ALL). High hyperdiploidy (HD), the most common cytogenetic subtype of childhood ALL, is enriched in children with RASopathies who develop ALL and, similarly, a high proportion of ALL patients with germline ETV6or IKZF1mutations presented with the HD subtype. Here, we aimed to identify novel predisposition genes in a selected group of HD-ALL patients.

Published
2018
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11. EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

Author

Fares, Iman, Chagraoui, Jalila, Lehnertz, Bernhard, MacRae, Tara, Mayotte, Nadine, Tomellini, Elisa, Aubert, Léo, Roux, Philippe P., and Sauvageau, Guy

Subjects
*CORD blood, *ENDOTHELIAL cells, *GENE expression, *STEM cell factor, *LABORATORY mice
Abstract

A small subset of human cord blood CD34+ cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171. In this article, we show that EPCR-positive UM171-treated cells, as opposed to EPCR-negative cells, exhibit robust multilineage repopulation and serial reconstitution ability in immunocompromised mice. In contrast to other stem cell markers, such as CD38, EPCR expression is maintained when cells are introduced in culture, irrespective of UM171 treatment. Although engineered overexpression of EPCR fails to reproduce the effects of UM171 on HSC activity, its expression is required for the repopulating activity of human HSCs. Altogether, our results indicate that EPCR is a reliable and cell culture-compatible marker of UM171-expanded human cord blood HSCs. [ABSTRACT FROM AUTHOR]

Published
2017
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