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6 results on '"Sasaki, Takehiko"'

1. Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation

Author

Kato, Takayasu, primary, Kiyoki, Yusuke, additional, Kito, Sakura, additional, Matsuzaka, Takashi, additional, Morioka, Shin, additional, Sasaki, Junko, additional, Sakamoto, Tatsuhiro, additional, Nishikii, Hidekazu, additional, Obara, Naoshi, additional, Sakata-Yanagimoto, Mamiko, additional, Sasaki, Takehiko, additional, Shimano, Hitoshi, additional, and Chiba, Shigeru, additional

Published
2022
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3. Regulation of FcγR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3–mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup

Author

Horan, Kristy A., primary, Watanabe, Ken-ichi, additional, Kong, Anne M., additional, Bailey, Charles G., additional, Rasko, John E. J., additional, Sasaki, Takehiko, additional, and Mitchell, Christina A., additional

Published
2007
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4. The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells

Author

Kishimoto, Hiroyuki, primary, Ohteki, Toshiaki, additional, Yajima, Nobuyuki, additional, Kawahara, Koichi, additional, Natsui, Miyuki, additional, Kawarasaki, Satoru, additional, Hamada, Koichi, additional, Horie, Yasuo, additional, Kubo, Yoshiaki, additional, Arase, Seiji, additional, Taniguchi, Masaru, additional, Vanhaesebroeck, Bart, additional, Mak, Tak Wah, additional, Nakano, Toru, additional, Koyasu, Shigeo, additional, Sasaki, Takehiko, additional, and Suzuki, Akira, additional

Published
2006
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6. The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells

Author

Kishimoto, Hiroyuki, Ohteki, Toshiaki, Yajima, Nobuyuki, Kawahara, Koichi, Natsui, Miyuki, Kawarasaki, Satoru, Hamada, Koichi, Horie, Yasuo, Kubo, Yoshiaki, Arase, Seiji, Taniguchi, Masaru, Vanhaesebroeck, Bart, Mak, Tak Wah, Nakano, Toru, Koyasu, Shigeo, Sasaki, Takehiko, and Suzuki, Akira

Abstract

The tumor suppressor PTEN is mutated in many human cancers. We previously used the Cre-loxP system to generate mice (LckCrePten mice) with a Pten mutation in T-lineage cells. Here we describe the phenotype of Pten-deficient Vα14iNKT cells. A failure in the development of Vα14iNKT cells occurs in the LckCrePten thymus between stage 2 (CD44highNK1.1−) and stage 3 (CD44highNK1.1+), resulting in decreased numbers of peripheral Vα14iNKT cells. In vitro, Pten-deficient Vα14iNKT cells show reduced proliferation and cytokine secretion in response to αGalCer stimulation but enhanced inhibitory Ly49 receptor expression. Following interaction with dendritic cells (DCs) loaded with αGalCer, Pten-deficient Vα14iNKT cells demonstrate activation of PI3K. Indeed, the effects of the Pten mutation require intact function of the PI3K subunits p110γ and p110δ. In vivo, LckCrePten mice display reduced serum IFNγ after αGalCer administration. Importantly, Vα14iNKT cell–mediated protection against the metastasis of melanoma cells to the lung was impaired in the absence of Pten. Thus, the Pten/PI3K pathway is indispensable for the homeostasis and antitumor surveillance function of Vα14iNKT cells.

Published
2007
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