Search

Your search keyword '"Shen, Ying"' showing total 18 results
Start Over Author "Shen, Ying" Journal blood
18 results on '"Shen, Ying"'

1. IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients

Author

Weller, Sandra, Bonnet, Mélanie, Delagreverie, Héloïse, Israel, Laura, Chrabieh, Maya, Maródi, László, Rodriguez-Gallego, Carlos, Garty, Ben-Zion, Roifman, Chaim, Issekutz, Andrew C., Zitnik, Simona Eva, Hoarau, Cyrille, Camcioglu, Yildiz, Vasconcelos, Júlia, Rodrigo, Carlos, Arkwright, Peter D., Cerutti, Andrea, Meffre, Eric, Zhang, Shen-Ying, Alcais, Alexandre, Puel, Anne, Casanova, Jean-Laurent, Picard, Capucine, Weill, Jean-Claude, and Reynaud, Claude-Agnès

Published
2012
Full Text
View/download PDF

2. Long-Term Follow-up of a Phase 1, First-in-Human Open-Label Study of LCAR-B38M, a Structurally Differentiated Chimeric Antigen Receptor T (CAR-T) Cell Therapy Targeting B-Cell Maturation Antigen (BCMA), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)

Author

Wang, Bai-Yan, primary, Zhao, Wan-Hong, primary, Liu, Jie, primary, Chen, Yin-Xia, primary, Cao, Xing-Mei, primary, Yang, Yun, primary, Zhang, Yi-Lin, primary, Wang, Fang-Xia, primary, Zhang, Peng-Yu, primary, Lei, Bo, primary, Gu, Liu-Fang, primary, Wang, Jian-Li, primary, Zhang, Jia-Jia, primary, Zhang, Ru, primary, Zhang, Hui, primary, Shen, Ying, primary, Bai, Ju, primary, Xu, Yan, primary, Wang, Xu-Geng, primary, Zhang, Rui-Li, primary, Wei, Li-Li, primary, Li, Zong-Fang, primary, He, Gai-Xia, primary, Geng, Yan, primary, He, Qian, primary, Zhuang, Qiu-Chuan, primary, Fan, Frank Xiao-Hu, primary, Zhang, Wang-Gang, primary, and He, Ai-Li, primary

Published
2019
Full Text
View/download PDF

9. Updated Analysis of a Phase 1, Open-Label Study of LCAR-B38M, a Chimeric Antigen Receptor T Cell Therapy Directed Against B-Cell Maturation Antigen, in Patients with Relapsed/Refractory Multiple Myeloma

Author

Zhao, Wan-Hong, primary, Liu, Jie, additional, Wang, Bai-Yan, additional, Chen, Yin-Xia, additional, Cao, Xing-Mei, additional, Yang, Yun, additional, Zhang, Yi-Lin, additional, Wang, Fang-Xia, additional, Zhang, Peng-Yu, additional, Lei, Bo, additional, Gu, Liu-Fang, additional, Wang, Jian-Li, additional, Yang, Nan, additional, Zhang, Ru, additional, Zhang, Hui, additional, Shen, Ying, additional, Bai, Ju, additional, Xu, Yan, additional, Wang, Xu-Geng, additional, Zhang, Rui-Li, additional, Wei, Li-Li, additional, Li, Zong-Fang, additional, Li, Zhen-Zhen, additional, Geng, Yan, additional, He, Qian, additional, Zhuang, Qiu-Chuan, additional, Fan, Frank Xiao-Hu, additional, He, Ai-Li, additional, and Zhang, Wang-Gang, additional

Published
2018
Full Text
View/download PDF

14. Serum Peptidome Based Multiple Myeloma Renal Impairment Biomarker Screening

Author

Bai, Ju, primary, He, Aili, additional, Zhang, Wanggang, additional, Yang, Yun, additional, Wang, Jianli, additional, Zhang, Pengyu, additional, Feng, Yuandong, additional, Zhang, Lei, additional, Chen, Hongli, additional, Wang, Xiaman, additional, Lei, Xiaoru, additional, Shen, Ying, additional, and Huang, Lingjuan, additional

Published
2015
Full Text
View/download PDF

16. Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

Author

Mazumdar, Claire, primary, Shen, Ying, additional, Xavy, Seethu, additional, Zhao, Feifei, additional, Reinisch, Andreas, additional, Li, Rui, additional, Corces-Zimmerman, Michael Ryan, additional, Buenrostro, Jason, additional, Chan, Steven M., additional, Thomas, Daniel, additional, Koenig, Julie, additional, Hong, Wan-Jen, additional, Chang, Howard, additional, and Majeti, Ravi, additional

Published
2015
Full Text
View/download PDF

17. IgM+IgD+CD27+B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients

Author

Weller, Sandra, Bonnet, Mélanie, Delagreverie, Héloïse, Israel, Laura, Chrabieh, Maya, Maródi, László, Rodriguez-Gallego, Carlos, Garty, Ben-Zion, Roifman, Chaim, Issekutz, Andrew C., Zitnik, Simona Eva, Hoarau, Cyrille, Camcioglu, Yildiz, Vasconcelos, Júlia, Rodrigo, Carlos, Arkwright, Peter D., Cerutti, Andrea, Meffre, Eric, Zhang, Shen-Ying, Alcais, Alexandre, Puel, Anne, Casanova, Jean-Laurent, Picard, Capucine, Weill, Jean-Claude, and Reynaud, Claude-Agnès

Abstract

We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of the TLR-signaling pathways (MyD88, TIRAP/MAL, IL-1 receptor–associated kinase 4 [IRAK-4], TLR3, UNC-93B, TRIF). All TLRs, except TLR3, which signals through the TRIF adaptor, require MyD88 and IRAK-4 to mediate their function. TLR4 and the TLR2 heterodimers (with TLR1, TLR6, and possibly TLR10) require in addition the adaptor TIRAP, whereas UNC-93B is needed for the proper localization of intracellular TLR3, TLR7, TLR8, and TLR9. We found that IgM+IgD+CD27+but not switched B cells were strongly reduced in MyD88-, IRAK-4-, and TIRAP-deficient patients. This defect did not appear to be compensated with age. However, somatic hypermutation of Ig genes and heavy-chain CDR3 size distribution of IgM+IgD+CD27+B cells were not affected in these patients. In contrast, the numbers of IgM+IgD+CD27+B cells were normal in the absence of TLR3, TRIF, and UNC-93B, suggesting that UNC-93B–dependent TLRs, and notably TLR9, are dispensable for the presence of this subset in peripheral blood. Interestingly, TLR10 was found to be expressed at greater levels in IgM+IgD+CD27+compared with switched B cells in healthy patients. Hence, we propose a role for TIRAP-dependent TLRs, possibly TLR10 in particular, in the development and/or maintenance of IgM+IgD+CD27+B cells in humans.

Published
2012
Full Text
View/download PDF

18. IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TERAP- but not UNC-93B-deficient patients.

Author

Weller, Sandra, Bonnet, Melanie, Delagreverie, Héloïse, Israel, Laura, Chrabieh, Maya, Maródi, László, Rodriguez-Gallego, Carlos, Garty, Ben-Zion, Roifman, Chaim, Issekutz, Andrew C., Eva Zitnik, Simona, Hoarau, Cyrille, Camcioglu, Yildiz, Vasconcelos, Júlia, Rodrigo, Carlos, Arkwright, Peter D., Cerutti, Andrea, Meffre, Eric, Shen-Ying Zhang, and Alcais, Alexandre

Subjects
*B cells, *TOLL-like receptors, *KINASES, *IMMUNOGLOBULINS, *PATIENTS
Abstract

We studied the distribution of peripheral B-cell subsets in patients deficient for key factors of the TLR-signaling path ways (MyD88, TIRAP/MAL, IL-1 receptor associated kinase 4 [IRAK-4], TLR3, UNC 93B, TRIF). All TLRs, except TLR3, which signals through the TRIF adaptor, require MyD88 and IRAK-4 to mediate their func tion. TLR4 and the TLR2 heterodimers (with TLR1, TLR6, and possibly TLR10) require in addition the adaptor TIRAP, whereas UNC-93B is needed for the proper localization of intracellular TLR3, TLR7, TLR8, and TLR9. We found that lgM+lgD+CD27+ but not switched B cells were strongly reduced in MyD88-, IRAK 4-, and TIRAP-deficient patients. This de fect did not appear to be compensated with age. However, somatic hypermuta-tion of Ig genes and heavy-chain CDR3 size distribution of lgM+lgD+CD27+ B cells were not affected in these pa tients. In contrast, the numbers of lgM+lgD+CD27+ B cells were normal in the absence of TLR3, TRIF, and UNC-93B, suggesting that UNC-93B-dependent TLRs, and notably TLR9, are dispensable for the presence of this subset in periph eral blood. Interestingly, TLR10 was found to be expressed at greater levels in lgM+lgD+CD27+ compared with switched B cells in healthy patients. Hence, we propose a role for TIRAP-dependent TLRs, possibly TLR10 in particular, in the development and/or maintenance of lgM+lgD+CD27+ B cells in humans. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results