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Your search keyword '"Singh, A. R."' showing total 15 results
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15 results on '"Singh, A. R."'

11. Use of 111-Indium–labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

Author

Farahi, Neda, primary, Singh, Nanak R., additional, Heard, Sarah, additional, Loutsios, Chrystalla, additional, Summers, Charlotte, additional, Solanki, Chandra K., additional, Solanki, Kishor, additional, Balan, Kottekkattu K., additional, Ruparelia, Prina, additional, Peters, A. Michael, additional, Condliffe, Alison M., additional, and Chilvers, Edwin R., additional

Published
2012
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15. Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma.

Author

Changju Qu, Yadong Liu, Kunkalla, Kranthi, Singh, Rajesh R., Blonska, Marzenna, Xin Lin, Agarwal, Nitin Kumar, and Vega, Francisco

Subjects
*LYMPHOMAS, *B cell lymphoma, *TUMOR growth, *HEDGEHOG signaling proteins, *CELLULAR signal transduction, *G proteins
Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Aberrant activation of Hedgehog (Hh) and nuclear factor (NF)-κB pathways is ubiquitously observed and known to mediate tumor growth, survival, and chemoresistance in DLBCL. Here, we find that activation of Hh signaling is positively correlated with NF-κB pathway in DLBCL tumors, and that smoothened (SMO), the signal transducer subunit of Hh pathway, contributes to NF-κB activation through recruiting G protein subunits Gai and Ga12 to activate PKCf}/CARMA1/TRAF6/NEMO signaling axis followed by assembling of the CARMA1/BCL10/MALT17TRAF6 complex to SMO. Moreover, functional inhibition of SMO enhances the cytotoxic effects of NF-κB inhibitor. Altogether, our study reveals a noncanonical Hh signaling pathway in which SMO activates trimeric G proteins and CARMA1-associated signaling complex, leading to NF-κB activation. This signaling cascade contributes to the survival of DLBCL and may serve as a potential target for combination therapies in DLBCL. [ABSTRACT FROM AUTHOR]

Published
2013
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