1. Donor-derived MDS/AML in families with germline GATA2 mutation
- Author
-
Steven M. Holland, Jeffery M. Klco, Sally Arai, Weixin Wang, Jason R. Schwartz, Katherine R. Calvo, Stephenie Droll, Mark Parta, Luke Maese, Rui Chen, Amy P. Hsu, Christa S. Zerbe, Pallavi Galera, Dennis D. Hickstein, and Neal S. Young
- Subjects
0301 basic medicine ,Mutation ,medicine.medical_treatment ,Immunology ,GATA2 ,Bone marrow failure ,Cell Biology ,Hematology ,Hematopoietic stem cell transplantation ,Biology ,medicine.disease ,medicine.disease_cause ,Biochemistry ,Germline ,03 medical and health sciences ,Leukemia ,030104 developmental biology ,0302 clinical medicine ,Germline mutation ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Haploinsufficiency - Abstract
TO THE EDITOR: GATA2 encodes a zinc-finger transcription factor that is required for proliferation and survival of hematopoietic stem cells.[1][1] First described in 2011, germline heterozygous mutations in GATA2 lead to haploinsufficiency[2][2] and are associated with bone marrow failure
- Published
- 2018