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1. DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features

Author

Arribas, Alberto J., Rinaldi, Andrea, Mensah, Afua A., Kwee, Ivo, Cascione, Luciano, Robles, Eloy F., Martinez-Climent, Jose A., Oscier, David, Arcaini, Luca, Baldini, Luca, Marasca, Roberto, Thieblemont, Catherine, Briere, Josette, Forconi, Francesco, Zamò, Alberto, Bonifacio, Massimiliano, Mollejo, Manuela, Facchetti, Fabio, Dirnhofer, Stephan, Ponzoni, Maurilio, Bhagat, Govind, Piris, Miguel A., Gaidano, Gianluca, Zucca, Emanuele, Rossi, Davide, and Bertoni, Francesco

Published
2015
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2. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome

Author

Chigrinova, Ekaterina, Rinaldi, Andrea, Kwee, Ivo, Rossi, Davide, Rancoita, Paola M.V., Strefford, Jonathan C., Oscier, David, Stamatopoulos, Kostas, Papadaki, Theodora, Berger, Francoise, Young, Ken H., Murray, Fiona, Rosenquist, Richard, Greiner, Timothy C., Chan, Wing C., Orlandi, Ester M., Lucioni, Marco, Marasca, Roberto, Inghirami, Giorgio, Ladetto, Marco, Forconi, Francesco, Cogliatti, Sergio, Votavova, Hana, Swerdlow, Steven H., Stilgenbauer, Stephan, Piris, Miguel A., Matolcsy, Andras, Spagnolo, Dominic, Nikitin, Eugene, Zamò, Alberto, Gattei, Valter, Bhagat, Govind, Ott, German, Zucca, Emanuele, Gaidano, Gianluca, and Bertoni, Francesco

Published
2013
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4. B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Author

Chakraborty, Supriya, primary, Martines, Claudio, additional, Porro, Fabiola, additional, Fortunati, Ilaria, additional, Bonato, Alice, additional, Dimishkovska, Marija, additional, Piazza, Silvano, additional, Yadav, Brijesh S., additional, Innocenti, Idanna, additional, Fazio, Rosa, additional, Vaisitti, Tiziana, additional, Deaglio, Silvia, additional, Zamò, Alberto, additional, Dimovski, Aleksandar J., additional, Laurenti, Luca, additional, and Efremov, Dimitar G., additional

Published
2021
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5. Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome

Author

Chakraborty, Supriya, primary, Martines, Claudio, additional, Porro, Fabiola, additional, Fortunati, Ilaria, additional, Bonato, Alice, additional, Dimishkovska, Marija, additional, Yadav, Brijesh, additional, Innocenti, Idanna, additional, Fazio, Rosa, additional, Vaisitti, Tizianna, additional, Deaglio, Silvia, additional, Zamò, Alberto, additional, Dimovski, Aleksandar, additional, Laurenti, Luca, additional, and Efremov, Dimitar G, additional

Published
2020
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6. Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Author

Scarfò, Irene, Pellegrino, Elisa, Mereu, Elisabetta, Kwee, Ivo, Agnelli, Luca, Bergaggio, Elisa, Garaffo, Giulia, Vitale, Nicoletta, Caputo, Manuel, Machiorlatti, Rodolfo, Circosta, Paola, Abate, Francesco, Barreca, Antonella, Novero, Domenico, Mathew, Susan, Rinaldi, Andrea, Tiacci, Enrico, Serra, Sara, Deaglio, Silvia, Neri, Antonino, Falini, Brunangelo, Rabadan, Raul, Bertoni, Francesco, Inghirami, Giorgio, Piva, Roberto, Boi, Michela, Crescenzo, Ramona, Cuccuru, Giuditta, Gaudiano, Marcello, Lasorsa, Elena, Medico, Enzo, Messana, Katia, Spaccarotella, Elisa, Tabbò, Fabrizio, Todaro, Maria, Fornari, Alessandro, Chilosi, Marco, Zamò, Alberto, Facchetti, Fabio, Lonardi, Silvia, De Chiara, Anna, Fulciniti, Franco, Doglioni, Claudio, Ponzoni, Maurilio, Todoerti, Katia, De Wolf Peeters, Christiane, Tousseyn, Thomas, Van Loo, Peter, Geissinger, Eva, Muller Hermelink, Hans Konrad, Rosenwald, Andreas, Matolcsy, Andras, Piris, Miguel Angel, Rodriguez Pinilla, Maria E., AGOSTINELLI, CLAUDIO, PICCALUGA, PIER PAOLO, PILERI, STEFANO, Scarfò, Irene, Pellegrino, Elisa, Mereu, Elisabetta, Kwee, Ivo, Agnelli, Luca, Bergaggio, Elisa, Garaffo, Giulia, Vitale, Nicoletta, Caputo, Manuel, Machiorlatti, Rodolfo, Circosta, Paola, Abate, Francesco, Barreca, Antonella, Novero, Domenico, Mathew, Susan, Rinaldi, Andrea, Tiacci, Enrico, Serra, Sara, Deaglio, Silvia, Neri, Antonino, Falini, Brunangelo, Rabadan, Raul, Bertoni, Francesco, Inghirami, Giorgio, Piva, Roberto, Boi, Michela, Crescenzo, Ramona, Cuccuru, Giuditta, Gaudiano, Marcello, Lasorsa, Elena, Medico, Enzo, Messana, Katia, Spaccarotella, Elisa, Tabbò, Fabrizio, Todaro, Maria, Fornari, Alessandro, Chilosi, Marco, Zamò, Alberto, Facchetti, Fabio, Lonardi, Silvia, De Chiara, Anna, Fulciniti, Franco, Doglioni, Claudio, Ponzoni, Maurilio, Todoerti, Katia, Agostinelli, Claudio, Piccaluga, Pier Paolo, Pileri, Stefano, De Wolf-Peeters, Christiane, Tousseyn, Thoma, Van Loo, Peter, Geissinger, Eva, Muller-Hermelink, Hans Konrad, Rosenwald, Andrea, Matolcsy, Andra, Piris, Miguel Angel, Rodriguez-Pinilla, Maria E., Scarfò, I, Pellegrino, E, Mereu, E, Kwee, I, Agnelli, L, Bergaggio, E, Garaffo, G, Vitale, N, Caputo, M, Machiorlatti, R, Circosta, P, Abate, F, Barreca, A, Novero, D, Mathew, S, Rinaldi, A, Tiacci, E, Serra, S, Deaglio, S, Neri, A, Falini, B, Rabadan, R, Bertoni, F, Inghirami, G, Piva, R, the European T-Cell Lymphoma Study, Group, Doglioni, C, and Ponzoni, M

Subjects
0301 basic medicine, Untranslated region, Receptor, ErbB-4, Messenger, Mice, SCID, Biochemistry, Mice, 0302 clinical medicine, 5' Untranslated Region, HEK293 Cell, Mutant Protein, Mice, Inbred NOD, hemic and lymphatic diseases, 5' Untranslated RegionsAnimalsCodon, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, NIH 3T3 Cell, Regulation of gene expression, TransgenicMolecular Sequence DataMutant ProteinsNIH 3T3 CellsReceptor Protein-Tyrosine KinasesReceptor, Hematology, Long terminal repeat, Large-Cell, Gene Expression Regulation, Neoplastic, Receptor Protein-Tyrosine Kinase, Codon, Nonsense, 030220 oncology & carcinogenesis, Lymphoma, Large-Cell, Anaplastic, Human, Molecular Sequence Data, Immunology, ErbB-4RNA, Mice, Transgenic, Biology, 03 medical and health sciences, Complementary DNA, Animals, Humans, RNA, Messenger, Gene, NonsenseGene Expression Regulation, NeoplasticHEK293 CellsHumansLymphoma, Animal, Receptor Protein-Tyrosine Kinases, RNA, Cell Biology, Molecular biology, Gene expression profiling, HEK293 Cells, 030104 developmental biology, Inbred NODMice, NIH 3T3 Cells, Mutant Proteins, SCIDMice, AnaplasticMiceMice, 5' Untranslated Regions, 5' Untranslated RegionsAnimalsCodon, NonsenseGene Expression Regulation, NeoplasticHEK293 CellsHumansLymphoma, Large-Cell, AnaplasticMiceMice, Inbred NODMice, SCIDMice, TransgenicMolecular Sequence DataMutant ProteinsNIH 3T3 CellsReceptor Protein-Tyrosine KinasesReceptor, ErbB-4RNA, Messenger
Abstract

Anaplastic large-cell lymphoma (ALCL) is a clinical and biological heterogeneous disease that includes systemic anaplastic lymphoma kinase (ALK)-positive and ALK-negative entities. To discover biomarkers and/or genes involved in ALK-negative ALCL pathogenesis, we applied the cancer outlier profile analysis algorithm to a gene expression profiling data set including 249 cases of T-cell non-Hodgkin lymphoma and normal T cells. Ectopic coexpression of ERBB4 and COL29A1 genes was detected in 24% of ALK-negative ALCL patients. RNA sequencing and 5' RNA ligase-mediated rapid amplification of complementary DNA ends identified 2 novel ERBB4-truncated transcripts displaying intronic transcription start sites. By luciferase assays, we defined that the expression of ERBB4-aberrant transcripts is promoted by endogenous intronic long terminal repeats. ERBB4 expression was confirmed at the protein level by western blot analysis and immunohistochemistry. Lastly, we demonstrated that ERBB4-truncated forms show oncogenic potentials and that ERBB4 pharmacologic inhibition partially controls ALCL cell growth and disease progression in an ERBB4-positive patient-derived tumorgraft model. In conclusion, we identified a new subclass of ALK-negative ALCL characterized by aberrant expression of ERBB4-truncated transcripts carrying intronic 5' untranslated regions. © 2016 by The American Society of Hematology.

Published
2016

7. Lenalidomide Maintenance after Autologous Transplantation Prolongs PFS in Young MCL Patients: Results of the Randomized Phase III MCL 0208 Trial from Fondazione Italiana Linfomi (FIL)

Author

Ladetto, Marco, primary, Ferrero, Simone, additional, Evangelista, Andrea, additional, Mian, Michael, additional, Di Rocco, Alice, additional, Coggi, Angela, additional, Rossi, Giuseppe, additional, Re, Alessandro, additional, Stefoni, Vittorio, additional, Cavallo, Federica, additional, Chiappella, Annalisa, additional, Santoro, Armando, additional, Rusconi, Chiara, additional, Gomes da Silva, Maria, additional, Gotti, Manuel, additional, Molinari, Anna Lia, additional, Ballerini, Filippo, additional, Ferreri, Andres J M, additional, Bosi, Alberto, additional, Narni, Franco, additional, Stelitano, Caterina, additional, Zamò, Alberto, additional, Ciccone, Gianni, additional, Vitolo, Umberto, additional, Martelli, Maurizio, additional, and Cortelazzo, Sergio, additional

Published
2018
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8. Identification of a Novel Gene Expression Signature in Mantle Cell Lymphoma from the Fondazione Italiana Linfomi (FIL)-MCL-0208 Trial: A Focus on the B Cell Receptor Pathway

Author

Bomben, Riccardo, primary, Ferrero, Simone, additional, Dal Bo, Michele, additional, D'Agaro, Tiziana, additional, Re, Alessandro, additional, Evangelista, Andrea, additional, Carella, Angelo Michele, additional, Zamò, Alberto, additional, Vitolo, Umberto, additional, Omedè, Paola, additional, Rusconi, Chiara, additional, Arcaini, Luca, additional, Rigacci, Luigi, additional, Luminari, Stefano, additional, Cortelazzo, Sergio, additional, Ladetto, Marco, additional, and Gattei, Valter, additional

Published
2015
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12. NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Author

Pozzo, Federico, primary, Bittolo, Tamara, additional, Tissino, Erika, additional, Rossi, Francesca Maria, additional, Bomben, Riccardo, additional, Zucchetto, Antonella, additional, Benedetti, Dania, additional, Arruga, Francesca, additional, Gizdic, Branimir, additional, Degan, Massimo, additional, Bulian, Pietro, additional, D'Arena, Giovanni, additional, Di Raimondo, Francesco, additional, Zaja, Francesco, additional, Pozzato, Gabriele, additional, Zamò, Alberto, additional, Deaglio, Silvia, additional, Rossi, Davide, additional, Gaidano, Gianluca, additional, Del Poeta, Giovanni, additional, Dal Bo, Michele, additional, and Gattei, Valter, additional

Published
2014
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13. Genome-Wide Promoter Methylation Profiling Of Splenic Marginal Zone Lymphoma (SMZL) Identifies Two Subgroups Of Patients With Distinct Genetic and Biologic Features and Different Outcomes

Author

Arribas, Alberto J., primary, Rinaldi, Andrea, additional, Kwee, Ivo, additional, Mensah, Afua A., additional, Cascione, Luciano, additional, Martinez-Climent, Jose A., additional, Oscier, David, additional, Arcaini, Luca, additional, Baldini, Luca, additional, Marasca, Roberto, additional, Thieblemont, Catherine, additional, Soulier, Jean, additional, Forconi, Francesco, additional, Zamò, Alberto, additional, Bonifacio, Massimiliano, additional, Mollejo, Manuela, additional, Facchetti, Fabio, additional, Dirnhofer, Stephan, additional, Ponzoni, Maurilio, additional, Bhagat, Govind, additional, Piris, Miguel Angel A., additional, Gaidano, Gianluca, additional, Zucca, Emanuele, additional, Rossi, Davide, additional, and Bertoni, Francesco, additional

Published
2013
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14. The Elastin Microfibril Interfacer-1 (EMILIN-1) Is a Ligand for CD49d in Chronic Lymphocytic Leukemia Cells

Author

Tissino, Erika, primary, Benedetti, Dania, additional, Bomben, Riccardo, additional, Bo, Michele Dal, additional, Vaisitti, Tiziana, additional, Deaglio, Silvia, additional, Rossi, Davide, additional, Zaja, Francesco, additional, Pozzato, Gabriele, additional, Raimondo, Francesco Di, additional, Gaidano, Gianluca, additional, Del Poeta, Giovanni, additional, Zamò, Alberto, additional, Spessotto, Paola, additional, Doliana, Roberto, additional, Zucchetto, Antonella, additional, Colombatti, Alfonso, additional, and Gattei, Valter, additional

Published
2012
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15. Nucleophosmin-1 and Ribosome-Associated Components Are Constitutively Overexpressed in NOTCH1 Mutated IGHV Unmutated CLL

Author

Dal Bo, Michele, primary, Pozzo, Federico, additional, Bomben, Riccardo, additional, Zucchetto, Antonella, additional, Tissino, Erika, additional, Benedetti, Dania, additional, Degan, Massimo, additional, Rossi, Francesca Maria, additional, Bulian, Pietro, additional, D'Agaro, Tiziana, additional, Dereani, Sara, additional, Rossi, Davide, additional, Zamò, Alberto, additional, Zaja, Francesco, additional, Pozzato, Gabriele, additional, Di Raimondo, Francesco, additional, Gaidano, Gianluca, additional, Del Poeta, Giovanni, additional, and Gattei, Valter, additional

Published
2012
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17. SNP-Arrays Provide New Insights Into the Pathogenesis of Richter Syndrome (RS)

Author

Rinaldi, Andrea, primary, Chigrinova, Ekaterina, additional, Kwee, Ivo, additional, Rossi, Davide, additional, Rancoita, Paola MV, additional, Strefford, Jonathan C., additional, Oscier, David Graham, additional, Stamatopoulos, Kostas, additional, Papadaki, Theodora, additional, Berger, Francoise, additional, Young, Ken H., additional, Murray, Fiona, additional, Rosenquist, Richard, additional, Greiner, Timothy C., additional, Chan, Wing C., additional, Arcaini, Luca, additional, Lucioni, Marco, additional, Marasca, Roberto, additional, Inghirami, Giorgio, additional, Ladetto, Marco, additional, Forconi, Francesco, additional, Cogliatti, Sergio, additional, Votavova, Hana, additional, Swerdlow, Steven H., additional, Stilgenbauer, Stephan, additional, Piris, Miguel, additional, Matolcsy, Andras, additional, Spagnolo, Dominic, additional, Nikitin, Eugene, additional, Zamò, Alberto, additional, Gattei, Valter, additional, Pasqualucci, Laura, additional, Zucca, Emanuele, additional, Gaidano, Gianluca, additional, and Bertoni, Francesco, additional

Published
2011
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18. Improved Detection of the KIT D816V Mutation Using a Real-Time PCR Assay Allows a Finer Recognition of Patients with Indolent Systemic Mastocytosis

Author

Bonifacio, Massimiliano, primary, De Matteis, Giovanna, additional, De Benedittis, Caterina, additional, Perbellini, Omar, additional, Zamò, Alberto, additional, Bonadonna, Patrizia, additional, Paviati, Elisa, additional, Artuso, Anna, additional, Soverini, Simona, additional, Pizzolo, Giovanni, additional, Martinelli, Giovanni, additional, and Zanotti, Roberta, additional

Published
2011
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19. Delphi, a Data Warehouse to Discover Associations between Variables in Clinical Trials: Application to the Fondazione Italiana Linfomi (FIL) MCL0208 Phase III Trial

Author

Zaccaria, Gian Maria, Ferrero, Simone, Evangelista, Andrea, Rosati, Samanta, Castagneri, Cristina, Ghislieri, Marco, Daniela, Barbero, Genuardi, Elisa, Lo Schirico, Mariella, Zamò, Alberto, Vitolo, Umberto, Bomben, Riccardo, Gattei, Valter, Galimberti, Sara, Di Paolo, Antonello, Rossi, Davide, Gaidano, Gianluca, Di Rocco, Alice, Cortelazzo, Sergio, Boccadoro, Mario, Balestra, Gabriella, and Ladetto, Marco

Abstract

Background and aims.Data collection in clinical trials is becoming complex, with huge amount of clinical and biological variables that need to be recorded, verified and analyzed to confirm obvious and identify unexpected associations. Outside the medical field, data warehouses (DWs) are widely employed to achieve these objectives. To verify whether DWs might be useful for data quality and association analysis, a team of clinicians, biologists, statisticians and biomedical engineers developed DELPHI (“Data ELaboration to Predict Hypothetical assocIations”). The tool has been suited to a large clinical trial from the Fondazione Italiana Linfomi (FIL), including all the clinical, biological and mutational features collected both in the trial and in the ancillary studies. Herein we present the first results, related to baseline variables: 1) creation of a broad DW (including 350 variables for 300 patients, thus > 105data); 2) data harmonization and quality control; 3) discovery of unexpected associations and (in a later phase) outcome correlations; 4) results visualization.

Published
2017
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20. NOTCH1Mutated IGHVUnmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Author

Pozzo, Federico, Bittolo, Tamara, Tissino, Erika, Rossi, Francesca Maria, Bomben, Riccardo, Zucchetto, Antonella, Benedetti, Dania, Arruga, Francesca, Gizdic, Branimir, Degan, Massimo, Bulian, Pietro, D’Arena, Giovanni, Di Raimondo, Francesco, Zaja, Francesco, Pozzato, Gabriele, Zamò, Alberto, Deaglio, Silvia, Rossi, Davide, Gaidano, Gianluca, Del Poeta, Giovanni, Dal Bo, Michele, and Gattei, Valter

Abstract

Background:stabilizing mutations of NOTCH1have been identified in about 10% of chronic lymphocytic leukemia (CLL) cases at diagnosis, with a higher frequency in unmutated IGHV(IGHV-UM), immuno-chemorefractory or advanced disease phase CLL, and have been associated with particularly unfavourable prognosis (Rossi et al, Blood, 2012; Del Poeta et al, Br J Haematol, 2013; Stingelbauer et al, Blood, 2014). In CLL, all NOTCH1mutations disrupt the C-terminal PEST domain (about 80% of which are a 7544-7545delCT frameshift deletion) and cause an accumulation of an active NOTCH1 isoform.

Published
2014
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21. Nucleophosmin-1 and Ribosome-Associated Components Are Constitutively Overexpressed in NOTCH1Mutated IGHVUnmutated CLL

Author

Dal Bo, Michele, Pozzo, Federico, Bomben, Riccardo, Zucchetto, Antonella, Tissino, Erika, Benedetti, Dania, Degan, Massimo, Rossi, Francesca Maria, Bulian, Pietro, D'Agaro, Tiziana, Dereani, Sara, Rossi, Davide, Zamò, Alberto, Zaja, Francesco, Pozzato, Gabriele, Di Raimondo, Francesco, Gaidano, Gianluca, Del Poeta, Giovanni, and Gattei, Valter

Abstract

Abstract 3880

Published
2012
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