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20 results on '"Zhang, Yuan-Yuan"'

1. Distinct Immune Homeostasis Remodeling Patterns after HLA-Matched and Haploidentical Transplantation

Author

Guo, Huidong, primary, Guo, Liping, additional, Wang, Bixia, additional, Wang, Ming, additional, Hong, Yan, additional, Mo, Xiao-Dong, additional, Sun, Yuqian, additional, Zhang, Yuan-Yuan, additional, Wang, Zhidong, additional, Kong, Jun, additional, Yan, Chen-Hua, additional, Wang, Yu, additional, Xu, Lan-Ping, additional, Zhang, Xiaohui, additional, Chang, Ying-Jun, additional, and Huang, Xiao-Jun, additional

Published
2022
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2. Machine-Learning Based Early Warning System for Prediction for Disseminated Intravascular Coagulation after Allogeneic Hematopoietic Stem Cell Transplantation: A Nationwide Multicenter Study

Author

An, Zhuo-Yu, primary, Wu, Ye-Jun, additional, He, Yun, additional, Zhu, Xiao-Lu, additional, Su, Yan, additional, Wang, Chen-Cong, additional, Han, Tian-Xiao, additional, Fu, Hai-Xia, additional, Wang, Feng-Rong, additional, Mo, Xiao-Dong, additional, Wang, Yu, additional, Zhao, Xiang-Yu, additional, Zhang, Yuan-Yuan, additional, Han, Wei, additional, Chen, Huan, additional, Chen, Yao, additional, Yan, Chen-Hua, additional, Wang, Jing-Zhi, additional, Han, Ting-Ting, additional, Chen, Yu-Hong, additional, Cheng, Yi-Fei, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao Jun, additional, and Zhang, Xiaohui, additional

Published
2021
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4. Tacrolimus Plus High-Dose Dexamethasone Versus High-Dose Dexamethasone Alone As First-Line Treatment for Adult Immune Thrombocytopenia: The Phase 2, Open Label, Randomized Trial (TARGET 020)

Author

An, Zhuo-Yu, primary, Wu, Ye-Jun, additional, He, Yun, additional, Zhu, Xiao-Lu, additional, Shi, Hong-Xia, additional, Wang, Chen-Cong, additional, Jiang, Hao, additional, Lu, Jin, additional, Jiang, Qian, additional, Huang, Qiu-Sha, additional, Fu, Hai-Xia, additional, Wang, Feng-Rong, additional, Mo, Xiao-Dong, additional, Wang, Yu, additional, Zhao, Xiang-Yu, additional, Zhang, Yuan-Yuan, additional, Han, Wei, additional, Chen, Huan, additional, Chen, Yao, additional, Yan, Chen-Hua, additional, Wang, Jing-Zhi, additional, Han, Ting-Ting, additional, Chen, Yu-Hong, additional, Cheng, Yi-Fei, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiaohui, additional

Published
2021
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6. Development and Validation of a Prognostic Model for Transplant-Associated Thrombotic Microangiopathy Following Allogeneic Hematopoietic Stem Cell Transplantation

Author

Zhao, Peng, primary, Wu, Ye-Jun, additional, Qu, Qing-Yuan, additional, Chong, Shan, additional, Sun, Xiao-Wan, additional, Deng, Rui-Xin, additional, Liu, Xiao, additional, Zhu, Xiao-Lu, additional, Han, Wei, additional, Zhang, Yuan-Yuan, additional, Wang, Feng-Rong, additional, Mo, Xiao-Dong, additional, Yan, Chen-Hua, additional, Wang, Jing-Zhi, additional, Wang, Yu, additional, Chen, Huan, additional, Chen, Yu-Hong, additional, Zhao, Xiang-Yu, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Liu, Kaiyan, additional, Huang, Xiao-Jun, additional, and Zhang, Xiao-Hui, additional

Published
2020
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9. Prophylactic Intervention with N-Acetyl-L-Cysteine before Allotransplant Could Reduce the Occurrence of Poor Hematopoietic Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Kong, Yuan, primary, Wang, Yu, additional, Zhang, Yuan-Yuan, additional, Shi, Min-Min, additional, Mo, Xiao-Dong, additional, Sun, Yu-Qian, additional, Chang, Ying-Jun, additional, Xu, Lan-Ping, additional, Zhang, Xiaohui, additional, Liu, Kaiyan, additional, and Huang, Xiao-Jun, additional

Published
2018
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10. Myeloid-Derived Suppressor Cells (HLA-DR-/lowCD16-CD33+) Expanded By Granulocyte Colony-Stimulating Factor Can Prevent Acute Graft-Versus-Host Disease in Humanized Mouse and Patients Following HSCT

Author

Wang, Ke, primary, Lv, Meng, additional, Chang, Ying-Jun, additional, Zhao, Xiang-Yu, additional, Zhao, Xiao-Su, additional, Zhang, Yuan-Yuan, additional, Sun, Yu-Qian, additional, Wang, Zhi-Dong, additional, Suo, Pan, additional, Zhou, Yang, additional, Liu, Dan, additional, Zhai, Shu-Zhen, additional, Hong, Yan, additional, Wang, Yu, additional, Zhang, Xiao-Hui, additional, Xu, Lan-Ping, additional, Liu, Kaiyan, additional, and Huang, Xiao-Jun, additional

Published
2018
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11. Lower Incidence of Acute Gvhd Is Associated with the Rapid Recovery of CD4+CD25+CD45RA+ Regulatory T Cells in Patients Who Received Haploidentical Allografts from NIMA-Mismatched Donors: A Retrospective (development) and Prospective (validation) Cohort-Based Study

Author

Wang, Yu, primary, Zhao, Xiang-Yu, additional, Xu, Lan-Ping, additional, Han, Wei, additional, Chen, Huan, additional, Wang, Feng-Rong, additional, Mo, Xiao-Dong, additional, Zhang, Yuan-Yuan, additional, Zhao, Xiaosu, additional, Kong, Yuan, additional, Liu, Kaiyan, additional, Huang, Xiao-Jun, additional, and Chang, Ying-Jun, additional

Published
2016
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12. Association Between C-Reactive Protein in the First 1-3 Days Post-Transplant and Allogeneic Immune Reactions in Pediatric Haploidentical Stem Cell Transplantation

Author

Chen, Yao, primary, Liu, Kai-Yan, additional, Huang, Xiao-Jun, additional, Huan, Chen, additional, Wang, Feng-Rong, additional, Wang, Jing-Zhi, additional, Zhang, Xiao-Hui, additional, Chen, Yu-Hong, additional, Wang, Yu, additional, Han, Wei, additional, Chen-Hua, Yan, additional, Zhang, Yuan-Yuan, additional, and Xu, Lan-Ping, additional

Published
2016
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14. Tacrolimus and Danazol Combination As a Second-Line Therapeutic Strategy for Steroid-Resistant or Relapsed Immune Thrombocytopenia: A Prospective, Randomized, Multicenter, Open-Label Study

Author

An, Zhuo-Yu, He, Yun, Zhu, Xiao-lu, Huang, Qiu-Sha, Wu, Jin, Fu, Haixia, Zhang, Yuan-Yuan, Chang, Ying-jun, Zhao, Xiangyu, Liu, Kaiyan, and Zhang, Xiaohui

Abstract

Introduction:Immune thrombocytopenia (ITP) is an important health concern as a severe autoimmune bleeding disorder characterized by low platelet counts and an increased risk of bleeding. Traditionally, the first-line treatment for ITP involves glucocorticoids. However, a substantial number of patients develop resistance or relapse within the first year of treatment, presenting a formidable challenge for medical practitioners. The consequences of prolonged glucocorticoid therapy, such as severe adverse effects, further necessitate the exploration of alternative, more effective, and safer treatments. In recent years, tacrolimus, a potent calcineurin inhibitor, has emerged as a potential candidate for managing ITP. It has shown promising efficacy against anti-platelet antibody-mediated thrombocytopenia, thus expanding the therapeutic options for resistant or relapsed ITP patients. Our previous work ( BJH 2022) also highlighted the potential of tacrolimus in suppressing the activation of NLRP3 inflammasomes and the apoptosis of MSCs-C+ cells both in vivo and in vitro. This research formed a solid foundation for further investigation into the roles of tacrolimus in ITP. Building on this background, our current research focuses on evaluating the effectiveness and safety of combining tacrolimus and danazol as a second-line therapy for patients with steroid-resistant or relapsed ITP. This study was designed to provide a comprehensive understanding of this therapeutic combination, which could pave the way for optimized treatment regimens for ITP, ultimately improving patient outcomes and quality of life.

Published
2023
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19. Lower Incidence of Acute Gvhd Is Associated with the Rapid Recovery of CD4+CD25+CD45RA+Regulatory T Cells in Patients Who Received Haploidentical Allografts from NIMA-Mismatched Donors: A Retrospective (development) and Prospective (validation) Cohort-Based Study

Author

Wang, Yu, Zhao, Xiang-Yu, Xu, Lan-Ping, Han, Wei, Chen, Huan, Wang, Feng-Rong, Mo, Xiao-Dong, Zhang, Yuan-Yuan, Zhao, Xiaosu, Kong, Yuan, Liu, Kaiyan, Huang, Xiao-Jun, and Chang, Ying-Jun

Abstract

To investigate the effects of non-inherited maternal antigen (NIMA) on clinical outcomes and immune recovery, especially of regulatory T cells (Tregs), in patients who underwent unmanipulated haploidentical transplantation.A retrospective cohort (n=57) and a prospective cohort (n=88) were included. Reconstitution of immune subsets, including Tregs, was determined using multicolor flow cytometry. In the retrospective cohort, the cumulative incidence of grades II-IV acute GVHD in patients with NIMA-mismatched donors was significantly lower than that of cases with NIPA-mismatched donors (14.8% vs. 43.30%, P=0.018). Patients with higher percentages of CD4+CD25+CD45RA+T cells (naive Tregs) within CD4+T cells recovered on day 30 (≥1.55%) experienced a significantly lower incidence of grades II-IV acute GVHD than that of cases with lower percentages of naive Tregs (<1.55%) (13.8% vs. 46.4%, P=0.010). Multivariate analysis showed that NIMA mismatch and the percentages of naive Tregs were associated with the incidence of grades II-IV acute GVHD [P=0.050, and 0.031, respectively]. In the prospective cohort, the association of NIMA mismatch [HR=0.365, 95%CI, 0.169-0.786, P=0.010] or higher percentages of naive Tregs recovered on day 30 (≥1.55%) [HR=0.114, 95%CI, 0.027-0.479, P=0.003] with a lower cumulative incidence of grades II-IV acute GVHD was further demonstrated. No effects of NIMA mismatch on chronic GVHD, transplant-related mortality, relapse, disease-free survival, or overall survival were found. Our results confirmed the role of NIMA mismatch in acute GVHD and provided the first demonstration, based on clinical data, that recovered Tregs may be involved in the effects of NIMA on acute GVHD in a haploidentical transplant setting.

Published
2016
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