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8 results on '"Zhang Zhiyu"'

1. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML

Author

Li, Zejuan, Huang, Hao, Li, Yuanyuan, Jiang, Xi, Chen, Ping, Arnovitz, Stephen, Radmacher, Michael D., Maharry, Kati, Elkahloun, Abdel, Yang, Xinan, He, Chunjiang, He, Miao, Zhang, Zhiyu, Dohner, Konstanze, Neilly, Mary Beth, Price, Colles, Lussier, Yves A., Zhang, Yanming, Larson, Richard A., Le Beau, Michelle M., Caligiuri, Michael A., Bullinger, Lars, Valk, Peter J.M., Delwel, Ruud, Lowenberg, Bob, Liu, Paul P., Marcucci, Guido, Bloomfield, Clara D., Rowley, Janet D., and Chen, Jianjun

Published
2012
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2. 11q Gain with t(11;14) or Alone Were Associated with Poor Prognosis in Newly-Diagnosed Multiple Myeloma Patients By SNP-Array Analysis and FISH

Author

Lu, Jiao, Fu, Chengcheng, Pan, Jinlan, Zeng, Zhao, Shang, Jingjing, Jin, Song, Yan, Lingzhi, Zhang, Zhiyu, You, Hongying, Shi, Xiaolan, Yan, Shuang, Yao, Weiqin, Wang, Jing, Xu, Yun, Wu, Chunxiao, Yan, Wanhui, Shen, Hongmiao, Huang, Yue, Xiang, Xin, Wang, Qian, Yan, Zhi, Wu, Xingyue, Wang, Qinrong, Wen, Lijun, Chen, Suning, and Wu, Depei

Published
2023
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3. CNVs Numbers Scoring System Was a Good Prognostic Risk Stratification for NDMM with Whole Genomic Mapping Array

Author

Zeng, Zhao, Fu, Chengcheng, Pan, Jinlan, Lu, Jiao, Shang, Jingjing, Zhang, Zhiyu, You, Hongying, Yan, Wanhui, Wu, Chunxiao, Wang, Qinrong, Wang, Qian, Wen, Lijun, Jin, Song, Yan, Lingzhi, Chen, Suning, and Wu, De-pei

Abstract

Multiple myeloma (MM) is a genetically heterogeneous disease characterized by plasma cell clonal proliferation. Due to the potential complex cytogenetic abnormalities, the clinical progresses are heterogeneous. Thus, genome-wide identification of cytogenetic abnormalities is necessary given the limitations of traditional cytogenetic detecting methods. In this study, we utilized whole genomic mapping methods Cytoscan 750K array to analyze the genomic copy number variations (CNVs) of 611 Newly Diagnosed MM (NDMM) from The First Affiliated Hospital of Soochow University.

Published
2023
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4. PBX3 is an important cofactor of HOXA9 in leukemogenesis

Author

Li, Zejuan, primary, Zhang, Zhiyu, additional, Li, Yuanyuan, additional, Arnovitz, Stephen, additional, Chen, Ping, additional, Huang, Hao, additional, Jiang, Xi, additional, Hong, Gia-Ming, additional, Kunjamma, Rejani B., additional, Ren, Haomin, additional, He, Chunjiang, additional, Wang, Chong-Zhi, additional, Elkahloun, Abdel G., additional, Valk, Peter J. M., additional, Döhner, Konstanze, additional, Neilly, Mary Beth, additional, Bullinger, Lars, additional, Delwel, Ruud, additional, Löwenberg, Bob, additional, Liu, Paul P., additional, Morgan, Richard, additional, Rowley, Janet D., additional, Yuan, Chun-Su, additional, and Chen, Jianjun, additional

Published
2013
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5. The HOXA/PBX3 Pathway Is an Attractive Therapeutic Target in MLL-Rearranged Acute Leukemia

Author

Li, Zejuan, primary, Zhang, Zhiyu, additional, Li, Yuanyuan, additional, Arnovitz, Stephen, additional, Chen, Ping, additional, Huang, Hao, additional, Jiang, Xi, additional, Hong, Gia-Ming, additional, He, Chunjiang, additional, Wang, Chong-Zhi, additional, Elkahloun, Abdel, additional, Valk, Peter J. M., additional, Dohner, Konstanze, additional, Neilly, Mary Beth, additional, Bullinger, Lars, additional, Delwel, Ruud, additional, Lowenberg, Bob, additional, Liu, Pu Paul, additional, Morgan, Richard, additional, Rowley, Janet D., additional, Yuan, Chun-Su, additional, and Chen, Jianjun, additional

Published
2012
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6. Activation of a Mir-181-Targeting HOXA-PBX3 Homeobox Gene Signature Is Associated with Adverse Prognosis of Cytogenetically Abnormal Acute Myeloid Leukemia

Author

Li, Zejuan, primary, Huang, Hao, additional, Li, Yuanyuan, additional, Jiang, Xi, additional, Chen, Ping, additional, Arnovitz, Stephen, additional, Radmacher, Michael D., additional, Maharry, Kati, additional, Elkahloun, Abdel, additional, Yang, Xinan, additional, He, Chunjiang, additional, Price, Colles O., additional, Dohner, Konstanze, additional, Zhang, Zhiyu, additional, Shen, Chen, additional, Neilly, Mary Beth, additional, Lussier, Yves A, additional, Zhang, Yanming, additional, Larson, Richard A., additional, Le Beau, Michelle M., additional, Caligiuri, Michael A, additional, Bullinger, Lars, additional, Valk, Peter, additional, Delwel, Ruud, additional, Lowenberg, Bob, additional, Liu, Paul P., additional, Marcucci, Guido, additional, Bloomfield, Clara D., additional, Rowley, Janet D., additional, and Chen, Jianjun, additional

Published
2011
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7. Up-regulation of a HOXA-PBX3homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML

Author

Li, Zejuan, Huang, Hao, Li, Yuanyuan, Jiang, Xi, Chen, Ping, Arnovitz, Stephen, Radmacher, Michael D., Maharry, Kati, Elkahloun, Abdel, Yang, Xinan, He, Chunjiang, He, Miao, Zhang, Zhiyu, Dohner, Konstanze, Neilly, Mary Beth, Price, Colles, Lussier, Yves A., Zhang, Yanming, Larson, Richard A., Le Beau, Michelle M., Caligiuri, Michael A., Bullinger, Lars, Valk, Peter J.M., Delwel, Ruud, Lowenberg, Bob, Liu, Paul P., Marcucci, Guido, Bloomfield, Clara D., Rowley, Janet D., and Chen, Jianjun

Abstract

Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P< .05; Cox regression) associated with favorable overall survival in cytogenetically abnormal AML (CA-AML) patients. We further show that up-regulation of a gene signature composed of 4 potential miR-181 targets (including HOXA7, HOXA9, HOXA11, and PBX3), associated with down-regulation of miR-181 family members, is an independent predictor of adverse overall survival on multivariable testing in analysis of 183 CA-AML patients. The independent prognostic impact of this 4-homeobox-gene signature was confirmed in a validation set of 271 CA-AML patients. Furthermore, our in vitro and in vivo studies indicated that ectopic expression of miR-181b significantly promoted apoptosis and inhibited viability/proliferation of leukemic cells and delayed leukemogenesis; such effects could be reversed by forced expression of PBX3. Thus, the up-regulation of the 4 homeobox genes resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable CA-AML. Restoring expression of miR-181b and/or targeting the HOXA/PBX3 pathways may provide new strategies to improve survival substantially.

Published
2012
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8. Activation of a Mir-181-Targeting HOXA-PBX3Homeobox Gene Signature Is Associated with Adverse Prognosis of Cytogenetically Abnormal Acute Myeloid Leukemia

Author

Li, Zejuan, Huang, Hao, Li, Yuanyuan, Jiang, Xi, Chen, Ping, Arnovitz, Stephen, Radmacher, Michael D., Maharry, Kati, Elkahloun, Abdel, Yang, Xinan, He, Chunjiang, Price, Colles O., Dohner, Konstanze, Zhang, Zhiyu, Shen, Chen, Neilly, Mary Beth, Lussier, Yves A, Zhang, Yanming, Larson, Richard A., Le Beau, Michelle M., Caligiuri, Michael A, Bullinger, Lars, Valk, Peter, Delwel, Ruud, Lowenberg, Bob, Liu, Paul P., Marcucci, Guido, Bloomfield, Clara D., Rowley, Janet D., and Chen, Jianjun

Abstract

Abstract 236

Published
2011
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