Search

Your search keyword '"Castagna, Luca"' showing total 7 results
Start Over Author "Castagna, Luca" Journal blood advances
7 results on '"Castagna, Luca"'

1. Selected memory T cells infused post–haploidentical hematopoietic stem cell transplantation persist and hyperexpand

Author

van Beek, Jasper J. P., Puccio, Simone, Di Vito, Clara, De Paoli, Federica, Zaghi, Elisa, Calvi, Michela, Scarpa, Alice, Peano, Clelia, Basso, Gianluca, Cibella, Javier, De Philippis, Chiara, Sarina, Barbara, Timofeeva, Inna, Capizzuto, Rossana, Mannina, Daniele, Mineri, Rossana, Mariotti, Jacopo, Crocchiolo, Roberto, Santoro, Armando, Castagna, Luca, Bramanti, Stefania, Mavilio, Domenico, and Lugli, Enrico

Published
2023
Full Text
View/download PDF

2. PTCy-based haploidentical vs matched related or unrelated donor reduced-intensity conditioning transplant for DLBCL.

Author

Dreger, Peter, Sureda, Anna, Ahn, Kwang, Eapen, Mary, Litovich, Carlos, Finel, Herve, Boumendil, Ariane, Gopal, Ajay, Herrera, Alex, Schmid, Christoph, Diez-Martin, José, Fuchs, Ephraim, Bolaños-Meade, Javier, Gooptu, Mahasweta, Al Malki, Monzr, Castagna, Luca, Ciurea, Stefan, Dominietto, Alida, Blaise, Didier, Ciceri, Fabio, Tischer, Johanna, Corradini, Paolo, Montoto, Silvia, Robinson, Stephen, Gülbas, Zafer, and Hamadani, Mehdi

Subjects
Adult, Aged, Female, Hematopoietic Stem Cell Transplantation, Humans, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Retrospective Studies, Tissue Donors, Transplantation Conditioning, Young Adult
Abstract

This study retrospectively compared long-term outcomes of nonmyeloablative/reduced intensity conditioning (NMC/RIC) allogeneic hematopoietic cell transplantation (allo-HCT) from a haploidentical family donor (haplo-HCT) using posttransplant cyclophosphamide (PTCy) with those of matched sibling donor (MSD) and matched unrelated donor (MUD) with or without T-cell depletion (TCD+/TCD-) in patients with relapsed diffuse large B-cell lymphoma (DLBCL). Adult patients with DLBCL who had undergone their first NMC/RIC allo-HCT between 2008 and 2015 were included. Recipients of haplo-HCT were limited to those receiving graft-versus-host disease (GVHD) prophylaxis with PTCy. GVHD prophylaxis in MSD was limited to calcineurin inhibitor (CNI)-based approaches without in vivo TCD, while MUD recipients received CNI-based prophylaxis with or without TCD. Outcome analyses for overall survival (OS) and progression-free survival (PFS), nonrelapse mortality (NRM), and disease relapse/progression were calculated. A total of 1438 patients (haplo, 132; MSD, 525; MUD TCD+, 403; and MUD TCD-, 378) were included. Patients with haplo donors were significantly older, had a better performance status and had more frequently received total body irradiation-based conditioning regimens and bone marrow grafts than MSD and MUD TCD+ or TCD-. 3-year OS, PFS, NRM and relapse/progression incidence after haplo-HCT was 46%, 38%, 22%, and 41%, respectively, and not significantly different from outcomes of matched donor transplants on multivariate analyses. Haplo-HCT was associated with a lower cumulative incidence of chronic GVHD compared with MSD, MUD TCD+/TCD-. NMC/RIC haplo-HCT with PTCy seems to be a valuable alternative for patients with DLBCL considered for allo-HCT but lacking a matched donor.

Published
2019

3. Outcome of allogeneic transplantation for mature T-cell lymphomas: impact of donor source and disease characteristics

Author

Hamadani, Mehdi, Ngoya, Maud, Sureda, Anna, Bashir, Qaiser, Litovich, Carlos Alejandro, Finel, Hervé, Chen, Yue, Boumendil, Ariane, Zain, Jasmine, Castagna, Luca, Cashen, Amanda F., Blaise, Didier, Shadman, Mazyar, Pastano, Rocco, Khimani, Farhad, Arat, Mutlu, Dietrich, Sascha, Schmitz, Norbert, Glass, Bertram, Kharfan-Dabaja, Mohamed A., Corradini, Paolo, Sauter, Craig S., Montoto, Silvia, Kwon, Mi, Herrera, Alex F., and Dreger, Peter

Published
2022
Full Text
View/download PDF

4. Impact of donor age and kinship on clinical outcomes after T-cell–replete haploidentical transplantation with PT-Cy

Author

Mariotti, Jacopo, Raiola, Anna Maria, Evangelista, Andrea, Carella, Angelo Michele, Martino, Massimo, Patriarca, Francesca, Risitano, Antonio, Bramanti, Stefania, Busca, Alessandro, Giaccone, Luisa, Brunello, Lucia, Merla, Emanuela, Savino, Lucia, Loteta, Barbara, Console, Giuseppe, Fanin, Renato, Sperotto, Alessandra, Marano, Luana, Marotta, Serena, Frieri, Camilla, Sica, Simona, Chiusolo, Patrizia, Harbi, Samia, Furst, Sabine, Santoro, Armando, Bacigalupo, Andrea, Blaise, Didier, Angelucci, Emanuele, Mavilio, Domenico, Castagna, Luca, and Bruno, Benedetto

Published
2020
Full Text
View/download PDF

5. Five-year results of the BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma

Author

Santoro, Armando, Mazza, Rita, Pulsoni, Alessandro, Re, Alessandro, Bonfichi, Maurizio, Zilioli, Vittorio Ruggero, Zanni, Manuela, Merli, Francesco, Anastasia, Antonella, Luminari, Stefano, Annechini, Giorgia, Gotti, Manuel, Peli, Annalisa, Liberati, Anna Marina, Di Renzo, Nicola, Castagna, Luca, Giordano, Laura, Ricci, Francesca, and Carlo-Stella, Carmelo

Published
2020
Full Text
View/download PDF

6. Selected memory T cells infused post haploidentical hematopoietic stem cell transplantation persist and hyper-expand

Author

van Beek, Jasper J. P., primary, Puccio, Simone, additional, Di Vito, Clara, additional, De Paoli, Federica, additional, Zaghi, Elisa, additional, Calvi, Michela, additional, Scarpa, Alice, additional, Peano, Clelia, additional, Basso, Gianluca, additional, Cibella, Javier, additional, De Philippis, Chiara, additional, Sarina, Barbara, additional, Timofeeva, Inna, additional, Capizzuto, Rossana, additional, Mannina, Daniele, additional, Mineri, Rossana, additional, Mariotti, Jacopo, additional, Crocchiolo, Roberto, additional, Santoro, Armando, additional, Castagna, Luca, additional, Bramanti, Stefania, additional, Mavilio, Domenico, additional, and Lugli, Enrico, additional

Published
2022
Full Text
View/download PDF

7. Checkpoint inhibition before haploidentical transplantation with posttransplant cyclophosphamide in Hodgkin lymphoma

Author

De Philippis, Chiara, primary, Legrand-Izadifar, Faezeh, primary, Bramanti, Stefania, primary, Giordano, Laura, primary, Montes de Oca, Catalina, primary, Duléry, Rémy, primary, Bouabdallah, Reda, primary, Granata, Angela, primary, Devillier, Raynier, primary, Mariotti, Jacopo, primary, Sarina, Barbara, primary, Harbi, Samia, primary, Maisano, Valerio, primary, Furst, Sabine, primary, Pagliardini, Thomas, primary, Weiller, Pierre-Jean, primary, Lemarie, Claude, primary, Calmels, Boris, primary, Chabannon, Christian, primary, Santoro, Armando, primary, Mohty, Mohamad, primary, Blaise, Didier, primary, and Castagna, Luca, primary

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results