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Your search keyword '"Pagliuca, Antonio"' showing total 6 results
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6 results on '"Pagliuca, Antonio"'

1. COVID-19 and CAR-T cells: current challenges and future directions-a report from the EPICOVIDEHA survey by EHA-IDWP

Author

Busca, Alessandro, Salmanton-García, Jon, Corradini, Paolo, Marchesi, Francesco, Cabirta, Alba, Di Blasi, Roberta, Dulery, Remy, Lamure, Sylvain, Farina, Francesca, Weinbergerová, Barbora, Batinić, Josip, Nordlander, Anna, López-García, Alberto, Drgoňa, Ľuboš, Espigado-Tocino, Ildefonso, Falces-Romero, Iker, García-Sanz, Ramón, García-Vidal, Carolina, Guidetti, Anna, Khanna, Nina, Kulasekararaj, Austin, Maertens, Johan, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A, and Pagano, Livio

Subjects
Prevention, Infection, Good Health and Well Being, COVID-19, Humans, Immunotherapy, Adoptive, Receptors, Chimeric Antigen, T-Lymphocytes
Abstract

The EHA-IDWP developed an observational registry collecting data on COVID-19 infection in patients who received CAR T-cell therapy. Prevalence of COVID-19 was 4.8%, and overall mortality was 50%, highlighting the need for prevention of infection in these patients.

Published
2022

3. COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey

Author

Lamure, Sylvain, primary, Salmanton-García, Jon, additional, Robin-Marieton, Elena, additional, Jaksic, Ozren, additional, Kohn, Milena, additional, Marchesi, Francesco, additional, Marchetti, Monia, additional, El-Ashwah, Shaimaa, additional, Demirkan, Fatih, additional, Valković, Toni, additional, Fernández, Noemí, additional, Tisi, Maria Chiara, additional, Stojanoski, Zlate, additional, Seval, Guldane Cengiz, additional, Ilhan, Osman, additional, Prezioso, Lucia, additional, Merelli, Maria, additional, López-García, Alberto, additional, Ledoux, Marie-Pierre, additional, Kulasekararaj, Austin, additional, González-López, Tomás-José, additional, Gomes da Silva, Maria, additional, Emarah, Ziad, additional, Duarte, Rafael F., additional, Cattaneo, Chiara, additional, Blennow, Ola, additional, Bilgin, Yavuz M., additional, Bergantim, Rui, additional, Batinić, Josip, additional, Cordoba, Raul, additional, Essame, Jenna, additional, Nordlander, Anna, additional, Nunes Rodrigues, Raquel, additional, Sacchi, Maria Vittoria, additional, Zompi, Sofia, additional, Busca, Alessandro, additional, Corradini, Paolo, additional, Hoenigl, Martin, additional, Klimko, Nikolai, additional, Koehler, Philipp, additional, Pagliuca, Antonio, additional, Passamonti, Francesco, additional, Duléry, Rémy, additional, Cornely, Oliver A., additional, Besson, Caroline, additional, and Pagano, Livio, additional

Published
2022
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4. COVID-19 and CAR T cells: a report on current challenges and future directions from the EPICOVIDEHA survey by EHA-IDWP

Author

Busca, Alessandro, Salmanton-García, Jon, Corradini, Paolo, Marchesi, Francesco, Cabirta, Alba, Di Blasi, Roberta, Dulery, Remy, Lamure, Sylvain, Farina, Francesca, Weinbergerová, Barbora, Batinić, Josip, Nordlander, Anna, López-García, Alberto, Drgoňa, Ľuboš, Espigado-Tocino, Ildefonso, Falces-Romero, Iker, García-Sanz, Ramón, García-Vidal, Carolina, Guidetti, Anna, Khanna, Nina, Kulasekararaj, Austin, Maertens, Johan, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., and Pagano, Livio

Published
2022
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5. Letermovir prophylaxis in T-cell–depleted transplants: breakthrough and rebound infections in the postmarketing setting

Author

Marzolini, Maria A.V., Mehra, Varun, Thomson, Kirsty J., Tholouli, Eleni, Bloor, Adrian J.C., Parker, Anne, Lovell, Richard, Orchard, Kim, Publicover, Amy, Nicholson, Emma, Snowden, John A., Byrne, Jennifer, Khan, Anjum, Gilleece, Maria H., Errico, Gerardo, Lozano, Sara, Hurst, Erin, Duncan, Nick, Pirrie, Jennifer, Crea, Philip, Carpenter, Ben, Pagliuca, Antonio, and Peggs, Karl S.

Published
2021
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6. COVID-19 and CAR-T cells: current challenges and future directions–a report from the EPICOVIDEHA survey by EHA-IDWP

Author

BUSCA, Alessandro, SALMANTON-GARCÍA, Jon, CORRADINI, Paolo, MARCHESI, Francesco, CABIRTA, Alba, DI BLASI, Roberta, DULERY, Remy, LAMURE, Sylvain, FARINA, Francesca, WEINBERGEROVÁ, Barbora, BATINIĆ, Josip, NORDLANDER, Anna, LÓPEZ-GARCÍA, Alberto, DRGOŇA, Ľuboš, ESPIGADO-TOCINO, Ildefonso, FALCES-ROMERO, Iker, GARCÍA-SANZ, Ramón, GARCÍA-VIDAL, Carolina, GUIDETTI, Anna, KHANNA, Nina, KULASEKARARAJ, Austin, MAERTENS, Johan, HOENIGL, Martin, KLIMKO, Nikolai, KOEHLER, Philipp, PAGLIUCA, Antonio, PASSAMONTI, Francesco, CORNELY, Oliver A., and PAGANO, Livio

Abstract

Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CAR-T recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CAR-T therapy. The European Hematology Association – Scientific Working Group Infection in Hematologyendorsed a survey to collect and analyze data from patients developing COVID-19 after CAR-T therapy. Overall, 459 patients treated with CAR-T cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CAR-T therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CAR-T patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.

Published
2021
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