1. Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation.
- Author
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Abe S, Hayashi H, Seo Y, Matsuda K, Kamio K, Saito Y, Usuki J, Azuma A, Kudo S, and Gemma A
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Oxygen analysis, Polymyxin B chemistry, Treatment Outcome, HMGB1 Protein blood, Hemoperfusion methods, Idiopathic Pulmonary Fibrosis blood, Idiopathic Pulmonary Fibrosis therapy, Polymyxin B therapeutic use
- Abstract
Background/aim: Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE., Materials and Methods: Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO(2))/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX., Results: PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column., Conclusion: PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE., (Copyright © 2011 S. Karger AG, Basel.)
- Published
- 2011
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