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1. Intradialytic Changes of Plasma Amino Acid Levels: Effect of Hemodiafiltration with Endogenous Reinfusion versus Acetate-Free Biofiltration

Author

Borrelli, S., primary, Minutolo, R., additional, De Nicola, L., additional, Zamboli, P., additional, Iodice, C., additional, De Paola, A., additional, De Simone, E., additional, Zito, B., additional, Guastaferro, P., additional, Nigro, F., additional, Apperti, V., additional, Iulianiello, G., additional, Credendino, O., additional, Iacono, G., additional, Di Serafino, A., additional, D’Apice, L., additional, Saviano, C., additional, Sarti, A., additional, Capuano, M., additional, Genualdo, R., additional, Auricchio, M., additional, Merola, M., additional, and Conte, G., additional

Published
2010
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2. Intradialytic changes of plasma amino acid levels: effect of hemodiafiltration with endogenous reinfusion versus acetate-free biofiltration

Author

Giuseppe Conte, Ludovica D'Apice, Silvio Borrelli, Raffaele Genualdo, Olga Credendino, L. De Nicola, G Iacono, A Sarti, B Zito, Pasquale Zamboli, Pasquale Guastaferro, Maria Rita Auricchio, V Apperti, Filippo Nigro, A De Paola, A Di Serafino, Caterina Saviano, Maria Capuano, Carmela Iodice, M Merola, E De Simone, Roberto Minutolo, G Iulianiello, Borrelli, S, Minutolo, Roberto, DE NICOLA, Luca, Zamboli, Pasquale, Iodice, C, DE PAOLA, A, DE SIMONE, E, Zito, B, Guastaferro, P, Nigro, F, Apperti, V, Iulianiello, G, Credendino, O, Iacono, G, DI SERAFINO, A, D'Apice, L, Saviano, C, Sarti, A, Capuano, M, Genualdo, R, Auricchio, M, Merola, M, and Conte, Giuseppe

Subjects
medicine.medical_specialty, medicine.medical_treatment, Endogeny, Hemodiafiltration, Renal Dialysis, Internal medicine, Diabetes mellitus, Hfr cell, medicine, Humans, Acetate-Free Biofiltration, Amino Acids, Dialysis, Aged, chemistry.chemical_classification, Chemistry, Hematology, General Medicine, Middle Aged, medicine.disease, Plasma amino acid levels, Hemodialysis Solutions, Amino acid, Endocrinology, Cross-Sectional Studies, Biochemistry, Nephrology, Hemodialysis
Abstract

During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1:1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (µmol/l) of total AA (3,176 ± 722), essential AA (889 ± 221), and branched chain AA (459 ± 140) levels in HFR were similar to those in AFB (3,399 ± 621, 938 ± 277, and 463 ± 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood.

Published
2010

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