1. Extracellular vesicles in physiological and pathological conditions.
- Author
-
Yuana Y, Sturk A, and Nieuwland R
- Subjects
- Blood Coagulation physiology, Body Fluids physiology, Cell Communication physiology, Cell Survival physiology, Cytosol metabolism, Endothelial Cells cytology, Endothelial Cells metabolism, Exocytosis physiology, Exosomes chemistry, Homeostasis physiology, Humans, Inflammation physiopathology, Lymphocytes cytology, Lymphocytes metabolism, Multivesicular Bodies chemistry, Neovascularization, Physiologic, Exosomes physiology, Extracellular Space metabolism, Multivesicular Bodies physiology
- Abstract
Body fluids contain surprising numbers of cell-derived vesicles which are now thought to contribute to both physiology and pathology. Tools to improve the detection of vesicles are being developed and clinical applications using vesicles for diagnosis, prognosis, and therapy are under investigation. The increased understanding why cells release vesicles, how vesicles play a role in intercellular communication, and how vesicles may concurrently contribute to cellular homeostasis and host defense, reveals a very complex and sophisticated contribution of vesicles to health and disease., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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