1. Metabolic Network Analysis: Implication And Application
- Author
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Syed Asad Rahman, Jyothi Padiadpu, Pardha Saradhi Jonnalagadda, Rainer Schrader, Kai Hartmann, and Dietmar Schomburg
- Subjects
Metabolic network analysis ,Applied Mathematics ,Metabolic network ,Choke ,Graph theory ,computer.file_format ,Biology ,computer.software_genre ,Biochemistry ,Computer Science Applications ,Ranking (information retrieval) ,Structural Biology ,Shortest path problem ,Key (cryptography) ,Data mining ,Executable ,Molecular Biology ,computer - Abstract
Pathway Alignment Tool (PAT) executables are availableupon request; Pathway Hunter Tool (PHT) is available onhttp://www.pht.uni-koeln.deLocal metabolic demand and supply regulate networkcomponents and control their activity globally. The use ofmetabolite structural information to calculate the shortestpath generates valid biochemical connectivity [1]. Weintroduce a new concept of "load points" for identifyingand empirically ranking the important points (metabo-lites/enzymes) in the network. The load point analysisprovides a global insight into the metabolic network,which cannot be obtained from connectivity informationor metabolic concentration data. We propose a new com-putational model based on extended graph theory to find"Choke point (CP)" and "Load point" enzymes (enzymesthat uniquely consume or produce a certain metabolite inthe network) [2]. Identifying such enzymes is the key tonetwork-based potential drug targeting [3]. We obtainedfew potential drug targets based on the "choke point"analysis of the network in the malarial parasite
- Published
- 2005
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