1. Predictive value of preoperative platelet-to-albumin ratio and apolipoprotein B-to-apolipoprotein A1 ratio for osteosarcoma in children and adolescents: a retrospective study of 118 cases
- Author
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Cong, Ma, Ruizhen, Li, Ronghui, Yu, Jingjing, Guo, Jianyun, Xu, Xuhui, Yuan, and Jianfeng, Guo
- Subjects
Male ,Cancer Research ,Children and adolescents ,Adolescent ,Bone Neoplasms ,Predictive Value of Tests ,Genetics ,Humans ,Lymphocyte Count ,Child ,Serum Albumin ,RC254-282 ,Retrospective Studies ,Osteosarcoma ,Apolipoprotein A-I ,Platelet Count ,Research ,Cholesterol, HDL ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cholesterol, LDL ,Prognosis ,Platelet-to-albumin ratio ,ROC Curve ,Oncology ,Area Under Curve ,Apolipoprotein B-to-apolipoprotein A1 ratio ,Apolipoprotein B-100 ,Preoperative Period ,Female ,lipids (amino acids, peptides, and proteins) ,Biomarkers - Abstract
Background This retrospective study investigated biomarkers that can reflect coagulation, inflammation, and lipid abnormalities: platelet-to-albumin ratio (PAR), platelet-to lymphocyte ratio (PLR), low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), apolipoprotein B-to-apolipoprotein ratio (ApoB/ApoA1) whether may be viable prognostic predictors in children and adolescents with osteosarcoma. Methods The retrospective review has enrolled a total of 118 children and adolescent patients diagnosed with osteosarcoma. Analyses with a receiver operating characteristic (ROC) curve were performed to evaluate the optimal cut-off values and to compare the area under curves (AUC). Kaplan–Meier curves were used to visualize survival outcome and a Cox proportional hazards model were used to confirm independent prognostic factors. Results Osteosarcoma patients in high PAR group (> 4.41) and high ApoB/ApoA1 group (> 0.82) experienced significantly shorter overall survival compared with those in low PAR group (≤ 4.41) and low ApoB/ApoA1 group (≤ 0.82). In univariate and multivariable analyses, preoperative PAR and ApoB/ApoA1 were identified as independent prognostic factors for OS in children and adolescents with osteosarcoma. Conclusion Preoperative PAR and ApoB/ApoA1 can be used as promising predictors in children and adolescents with osteosarcoma to help clinicians recognize patients with an increased risk of poor prognosis.
- Published
- 2022