1. Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan
- Author
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Chih Ching Yeh, Wen Chang Wang, Shih-Ni Chang, Fu Hsiung Su, Abram Bunya Kamiza, and Fung-Chang Sung
- Subjects
Adult ,Male ,Hepatitis B virus ,Cancer Research ,medicine.medical_specialty ,Hepatitis, Viral, Human ,Colorectal cancer ,Hepatitis C virus ,Population ,Taiwan ,Comorbidity ,medicine.disease_cause ,Gastroenterology ,Cancer risk ,03 medical and health sciences ,Hepatitis B, Chronic ,0302 clinical medicine ,Neoplasms ,Internal medicine ,Pancreatic cancer ,Genetics ,medicine ,Humans ,education ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,education.field_of_study ,Coinfection ,business.industry ,Incidence ,Liver Neoplasms ,Cancer ,Middle Aged ,medicine.disease ,Hepatitis C ,Oncology ,Population Surveillance ,030220 oncology & carcinogenesis ,Chronic Disease ,Female ,030211 gastroenterology & hepatology ,business ,Liver cancer ,Kidney cancer ,Biomarkers ,Research Article - Abstract
Background Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major causes of chronic hepatitis infection (CHI). This longitudinal cohort study investigated the association of CHI with hepatic and extrahepatic cancer development in Taiwan. Methods Patients with HBV infection and HCV infection were identified from the Taiwan National Health Insurance Research Database. A Cox proportional hazard model was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs) for determining the association between CHI and cancer development. Results The patients with HBV infection exhibited an increased risk of colorectal cancer (HR: 1.36, 95 % CI: 1.09–1.70), liver cancer (HR: 21.47, 95 % CI: 18.0–25.6), gallbladder and extrahepatic bile duct cancer (HR: 2.05, 95 % CI: 1.07–3.91), pancreatic cancer (HR: 2.61, 95 % CI: 1.47–4.61), kidney cancer (HR: 1.72, 95 % CI: 1.10–2.68), ovarian cancer (HR: 2.31, 95 % CI: 1.21–4.39), and non-Hodgkin’s lymphoma (HR: 2.10, 95 % CI: 1.25–3.52). The patients with HCV infection exhibited an increased risk of liver cancer (HR: 25.10, 95 % CI: 20.9–30.2), gallbladder and extrahepatic bile duct cancer (HR: 2.60, 95 % CI: 1.42–4.73), ovarian cancer (HR: 5.15, 95 % CI: 1.98–13.4), and non-Hodgkin’s lymphoma (HR: 2.30, 95 % CI: 1.34–3.96). Conclusion The present population-based study revealed that in addition to its association with primary liver cancer, CHI is associated with an increased risk of extrahepatic cancer.
- Published
- 2016