5 results on '"Jung-Han Kim"'
Search Results
2. Noncutaneous malignant melanoma: a prognostic model from a retrospective multicenter study
- Author
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Hyun Jung Jun, Jeeyun Lee, Soon Il Lee, Jung Han Kim, Hyo Song Kim, Keon Woo Park, Sung Yong Oh, Kyoung-Mee Kim, Dae Ho Lee, Do Hyoung Lim, and Eun Kyoung Kim
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Ocular Melanoma ,Kaplan-Meier Estimate ,lcsh:RC254-282 ,Risk Assessment ,Risk Factors ,Republic of Korea ,Genetics ,Humans ,Medicine ,Melanoma ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Mucous Membrane ,business.industry ,Proportional hazards model ,Genitourinary system ,Eye Neoplasms ,Carcinoma ,Mucosal melanoma ,Retrospective cohort study ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Surgery ,Radiation therapy ,Treatment Outcome ,Oncology ,Chemotherapy, Adjuvant ,Cutaneous melanoma ,Female ,Radiotherapy, Adjuvant ,business ,Research Article - Abstract
Background We performed multicenter study to define clinical characteristics of noncutaneous melanomas and to establish prognostic factors patients who received curative resection. Methods Of the 141 patients who were diagnosed of non-cutaneous melanoma at 4 institutions in Korea between June 1992 and May 2005, 129 (91.5%) satisfied the selection criteria. Results Of the 129 noncutaneous melanoma patients, 14 patients had ocular melanoma and 115 patients had mucosal melanoma. For mucosal melanoma, anorectum was the most common anatomic site (n = 39, 30.2%) which was followed by nasal cavity (n = 30, 23.3%), genitourinary (n = 21, 16.3%), oral cavity (n = 14, 10.9%), upper gastrointestinal tract (n = 6, 4.7%) and maxillary sinus (n = 5, 3.9%) in the order of frequency. With the median 64.5 (range 4.3-213.0) months follow-up, the median overall survival were 24.4 months (95% CI 13.2-35.5) for all patients, and 34.6 (95% CI 24.5-44.7) months for curatively resected mucosal melanoma patients. Adverse prognostic factors of survival for 87 curatively resected mucosal melanoma patients were complete resection (R1 resection margin), and age > 50 years. For 14 ocular melanoma, Survival outcome was much better than mucosal melanoma with 73.3% of 2 year OS and 51.2 months of median OS (P = .04). Conclusion Prognosis differed according to primary sites of noncutaneous melanoma. Based on our study, noncutaneous melanoma patients should be treated differently to improve survival outcome.
- Published
- 2010
3. Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival.
- Author
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Yoon-La Choi, Ensel Oh, Sarah Park, Yeonju Kim, Yeon-Hee Park, Kyoung Song, Eun Yoon Cho, Yun-Chul Hong, Jong Sun Choi, Jeong Eon Lee, Jung Han Kim, Seok Jin Nam, Young-Hyuck Im, Jung-Hyun Yang, and Young Kee Shin
- Subjects
IMMUNOHISTOCHEMISTRY ,DRUG therapy ,TRIPLE-negative breast cancer ,TISSUES ,CANCER patients ,HISTOLOGY - Abstract
Background: Triple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic significance between TNBCs and BLBCs. In this study, we aimed to characterize the prognostic features of TNBCs, in view of BLBCs and quintuple-negative breast cancers (QNBC/5NPs). Methods: Using tissue microarray-based immunohistochemical analysis, we categorized 951 primary breast cancers into four or five subtypes according to the expression of ER, PR, HER2, and basal markers (CK5/6, EGFR). Results: The results of this study showed that both TNBCs and BLBCs were associated with high histological and/ or nuclear grades. When the TNBCs are divided into two subtypes by the presence of basal markers, the clinicopathologic characteristics of TNBCs were mainly maintained in the BLBCs. The 5-subgrouping was the better prediction model for both disease free and overall survival in breast cancers than the 4-subgrouping. After multivariate analysis of TNBCs, the BLBCs did not have a worse prognosis than the QNBC/5NPs. Interestingly, the patients with BLBCs showed significant adjuvant chemotherapy benefit. In addition, QNBC/5NPs comprised about 6∼8% of breast cancers in publicly available breast cancer datasets Conclusion: The QNBC/5NP subtype is a worse prognostic subgroup of TNBCs, especially in higher stage and this result may be related to adjuvant chemotherapy benefit of BLBCs, calling for caution in the identification of subgroups of patients for therapeutic classification. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
4. Noncutaneous malignant melanoma: a prognosticmodel from a retrospective multicenter study.
- Author
-
Hyo Song Kim, Eun Kyoung Kim, Hyun Jung Jun, Sung Yong Oh, Keon Woo Park, Do Hyoung Lim, Soon Il Lee, Jung Han Kim, Kyoung Mee Kim, Dae Ho Lee, and Jeeyun Lee
- Subjects
MELANOMA ,NEUROENDOCRINE tumors ,SURGICAL excision ,MAXILLARY sinus ,GASTROINTESTINAL system ,NASAL cavity - Abstract
Background: We performed multicenter study to define clinical characteristics of noncutaneous melanomas and to establish prognostic factors patients who received curative resection. Methods: Of the 141 patients who were diagnosed of non-cutaneous melanoma at 4 institutions in Korea between June 1992 and May 2005, 129 (91.5%) satisfied the selection criteria. Results: Of the 129 noncutaneous melanoma patients, 14 patients had ocular melanoma and 115 patients had mucosal melanoma. For mucosal melanoma, anorectum was the most common anatomic site (n = 39, 30.2%) which was followed by nasal cavity (n = 30, 23.3%), genitourinary (n = 21, 16.3%), oral cavity (n = 14, 10.9%), upper gastrointestinal tract (n = 6, 4.7%) and maxillary sinus (n = 5, 3.9%) in the order of frequency. With the median 64.5 (range 4.3-213.0) months follow-up, the median overall survival were 24.4 months (95% CI 13.2-35.5) for all patients, and 34.6 (95% CI 24.5-44.7) months for curatively resected mucosal melanoma patients. Adverse prognostic factors of survival for 87 curatively resected mucosal melanoma patients were complete resection (R1 resection margin), and age > 50 years. For 14 ocular melanoma, Survival outcome was much better than mucosal melanoma with 73.3% of 2 year OS and 51.2 months of median OS (P = .04). Conclusion: Prognosis differed according to primary sites of noncutaneous melanoma. Based on our study, noncutaneous melanoma patients should be treated differently to improve survival outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
5. Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival
- Author
-
Seok Jin Nam, Eun Yoon Cho, Yeonju Kim, Jeong Eon Lee, Young-Hyuck Im, Jong Sun Choi, Sarah Park, Ensel Oh, Yun-Chul Hong, Yoon La Choi, Jung Han Kim, Yeon Hee Park, Young Kee Shin, Kyoung Song, and Jung-Hyun Yang
- Subjects
Oncology ,Adult ,medicine.medical_specialty ,Pathology ,Cancer Research ,Multivariate analysis ,medicine.medical_treatment ,Breast Neoplasms ,Medical Oncology ,lcsh:RC254-282 ,Disease-Free Survival ,Targeted therapy ,Basal (phylogenetics) ,Breast cancer ,Surgical oncology ,Internal medicine ,Genetics ,Medicine ,Humans ,Stage (cooking) ,In Situ Hybridization, Fluorescence ,Aged ,Oligonucleotide Array Sequence Analysis ,Aged, 80 and over ,Tissue microarray ,business.industry ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,Immunohistochemistry ,Treatment Outcome ,Multivariate Analysis ,Female ,business ,Research Article - Abstract
Background Triple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic significance between TNBCs and BLBCs. In this study, we aimed to characterize the prognostic features of TNBCs, in view of BLBCs and quintuple-negative breast cancers (QNBC/5NPs). Methods Using tissue microarray-based immunohistochemical analysis, we categorized 951 primary breast cancers into four or five subtypes according to the expression of ER, PR, HER2, and basal markers (CK5/6, EGFR). Results The results of this study showed that both TNBCs and BLBCs were associated with high histological and/or nuclear grades. When the TNBCs are divided into two subtypes by the presence of basal markers, the clinicopathologic characteristics of TNBCs were mainly maintained in the BLBCs. The 5-subgrouping was the better prediction model for both disease free and overall survival in breast cancers than the 4-subgrouping. After multivariate analysis of TNBCs, the BLBCs did not have a worse prognosis than the QNBC/5NPs. Interestingly, the patients with BLBCs showed significant adjuvant chemotherapy benefit. In addition, QNBC/5NPs comprised about 6~8% of breast cancers in publicly available breast cancer datasets Conclusion The QNBC/5NP subtype is a worse prognostic subgroup of TNBCs, especially in higher stage and this result may be related to adjuvant chemotherapy benefit of BLBCs, calling for caution in the identification of subgroups of patients for therapeutic classification.
- Full Text
- View/download PDF
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