11 results on '"Long, Yang"'
Search Results
2. Risk factors for postoperative recurrence in patients with stage II colorectal cancer
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Zhi-Zhong Xiong, Ming-Hao Xie, Xian-Zhe Li, Long-Yang Jin, Feng-Xiang Zhang, Shi Yin, Hua-Xian Chen, and Lei Lian
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Colorectal cancer ,Predictive factors ,Recurrence ,Stage II ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Recurrences are the main reasons for unfavorable outcomes for patients with stage II colorectal cancer (CRC). To obtain a clear understanding of the high-risk factors, further investigation is warranted. The present study aimed to analyze the risk factors associated with postoperative recurrence in patients with stage II CRC. Methods Eligible patients with pathologically confirmed stage II CRC were enrolled in the study retrospectively based on a prospectively maintained database from April 2008 to March 2019. The Kaplan–Meier method were used to calculate the overall survival (OS) rate and the cumulative recurrence rate. Univariate and multivariable Cox regression analyses were performed to identify risk factors for recurrence. Results There were 2515 patients included, of whom 233 (9.3%) developed local or distant recurrence. Recurrence was associated with a significantly worse 5-year OS (45.4% vs. 95.5%, p < 0.0001). The 5-year cumulative recurrence rate was 13.0% in patients with stage II CRC. On multivariable Cox analysis, tumor size (Hazard Ratio (HR) [95% confidence interval (CI)] = 1.79[1.38, 2.33]), preoperative carbohydrate antigen (CA) 125 level (HR [95% CI] = 1.78[1.17, 2.70]), preoperative CA 199 level (HR [95% CI] = 1.56[1.09, 2.22]), and ulcerating tumor (HR [95% CI] = 1.61[1.19, 2.17]) were found to be associated with postoperative recurrence. Adjuvant chemotherapy was associated with a lower cumulative recurrence rate in patients with these risk factors (p = 0.00096). Conclusion The tumor diameter, preoperative CA125 level, preoperative CA199 level, and an ulcerative tumor can predict postoperative recurrence in patients with stage II CRC, and postoperative chemotherapy could reduce the cumulative recurrence rate in patients with these high-risk factors.
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- 2023
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3. Correction to: KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription
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Qin, Mei, Han, Fei, Wu, Jian, Gao, Feng-xia, Li, Yuan, Yan, De-xin, He, Xue-mei, Long, Yang, Tang, Xiao-ping, Ren, De-lian, Gao, Yan, and Dai, Tian-yang
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- 2021
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4. KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription
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Qin, Mei, Han, Fei, Wu, Jian, Gao, Feng-xia, Li, Yuan, Yan, De-xin, He, Xue-mei, Long, Yang, Tang, Xiao-ping, Ren, De-lian, Gao, Yan, and Dai, Tian-yang
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- 2021
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5. NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression
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Jian Wang, Yamin Zhang, Lei Liu, Zilin Cui, Rui Shi, Jiancun Hou, Zirong Liu, Long Yang, Lianjiang Wang, and Yang Li
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NFAT2 ,HepG2 cells ,Hepatocellular carcinoma ,Cancer malignancy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. In this study, we aimed to explore the effect of NFAT2 expression on cell fate of HepG2 cell and its potential mechanisms. Methods Firstly, the pcDNA3.1-NFAT2 plasmid was transfected into HepG2 cells to construct NFAT2 overexpressed HepG2 cells. Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed. The expression of Egr2 and FasL, and the phosphorylation of AKT and ERK, after ionomycin and PMA co-stimulation, was detected, while the Ca2+ mobilization stimulated by K+ solution was determined. At last, the mRNA and protein expression of NFAT2, Egr2, FasL, COX-2 and c-myc in carcinoma and adjacent tissues was investigated. Results The NFAT2 overexpression suppressed the cell viability, invasion and migration capabilities, and promoted apoptosis of HepG2 cells. NFAT2 overexpression induced the expression of Egr2 and FasL and suppressed the phosphorylation of AKT and ERK. The sensitivity and Ca2+ mobilization of HepG2 cells was also inhibited by NFAT2 overexpression. Compared with adjacent tissues, the carcinoma tissues expressed less NFAT2, Egr2, FasL and more COX-2 and c-myc. Conclusion The current study firstly suggested that NFAT2 suppressed the aggression and malignancy of HepG2 cells through inducing the expression of Egr2. The absence of NFAT2 and Egr2 in carcinoma tissues reminded us that NFAT2 may be a promising therapeutic target for hepatocellular carcinoma treatment.
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- 2020
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6. NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression
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Lianjiang Wang, Lei Liu, Zilin Cui, Zirong Liu, Long Yang, Jian Wang, Ya-min Zhang, Jianchun Hou, Yang Li, and Rui Shi
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0301 basic medicine ,MAPK/ERK pathway ,Cancer Research ,Carcinoma, Hepatocellular ,Fas Ligand Protein ,Cell Survival ,Hepatocellular carcinoma ,Apoptosis ,Cancer malignancy ,Transfection ,lcsh:RC254-282 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Annexin ,Cell Movement ,Genetics ,Humans ,Viability assay ,Phosphorylation ,Protein kinase B ,HepG2 cells ,Early Growth Response Protein 2 ,NFATC Transcription Factors ,NFAT2 ,Liver Neoplasms ,Hep G2 Cells ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Up-Regulation ,030104 developmental biology ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Ionomycin ,Cancer research ,Calcium ,Proto-Oncogene Proteins c-akt ,Research Article - Abstract
Background Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. In this study, we aimed to explore the effect of NFAT2 expression on cell fate of HepG2 cell and its potential mechanisms. Methods Firstly, the pcDNA3.1-NFAT2 plasmid was transfected into HepG2 cells to construct NFAT2 overexpressed HepG2 cells. Then, the chemical count kit-8 cell viability assay, Annexin V-FITC apoptosis detection, EdU labeling proliferation detection, transwell and wound healing experiments were performed. The expression of Egr2 and FasL, and the phosphorylation of AKT and ERK, after ionomycin and PMA co-stimulation, was detected, while the Ca2+ mobilization stimulated by K+ solution was determined. At last, the mRNA and protein expression of NFAT2, Egr2, FasL, COX-2 and c-myc in carcinoma and adjacent tissues was investigated. Results The NFAT2 overexpression suppressed the cell viability, invasion and migration capabilities, and promoted apoptosis of HepG2 cells. NFAT2 overexpression induced the expression of Egr2 and FasL and suppressed the phosphorylation of AKT and ERK. The sensitivity and Ca2+ mobilization of HepG2 cells was also inhibited by NFAT2 overexpression. Compared with adjacent tissues, the carcinoma tissues expressed less NFAT2, Egr2, FasL and more COX-2 and c-myc. Conclusion The current study firstly suggested that NFAT2 suppressed the aggression and malignancy of HepG2 cells through inducing the expression of Egr2. The absence of NFAT2 and Egr2 in carcinoma tissues reminded us that NFAT2 may be a promising therapeutic target for hepatocellular carcinoma treatment.
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- 2020
7. KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription.
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Mei Qin, Fei Han, Jian Wu, Feng-xia Gao, Yuan Li, De-xin Yan, Xue-mei He, Yang Long, Xiao-ping Tang, De-lian Ren, Yan Gao, Tian-yang Dai, Qin, Mei, Han, Fei, Wu, Jian, Gao, Feng-Xia, Li, Yuan, Yan, De-Xin, He, Xue-Mei, and Long, Yang
- Abstract
Background: As an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression, KDM6B has been implicated in the development and malignant progression in various types of cancers. However, its potential roles in esophageal squamous cell carcinoma (ESCC) have not been explored.Methods: The expression of KDM6B in human ESCC tissues and cell lines was examined using RT-qPCR, immunohistochemical staining and immunoblotting. The effects of KDM6B on the proliferation and metastasis of ESCC were examined using in vitro and in vivo functional tests. RNA-seq and ChIP-seq assay were used to demonstrate the molecular biological mechanism of KDM6B in ESCC.Results: We show that the expression level of KDM6B increased significantly in patients with lymph node metastasis. Furthermore, we confirmed that KDM6B knockdown reduces proliferation and metastasis of ESCC cells, while KDM6B overexpression has the opposite effects. Mechanistically, KDM6B regulates TNFA_SIGNALING_VIA_NFκB signalling pathways, and H3K27me3 binds to the promoter region of C/EBPβ, leading to the promotion of C/EBPβ transcription. Besides, we show that GSK-J4, a chemical inhibitor of KDM6B, markedly inhibits proliferation and metastasis of ESCC cells.Conclusions: The present study demonstrated that KDM6B promotes ESCC progression by increasing the transcriptional activity of C/EBPβ depending on its H3K27 demethylase activity. [ABSTRACT FROM AUTHOR]- Published
- 2021
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8. The effects of psychological interventions on depression and anxiety among Chinese adults with cancer: a meta-analysis of randomized controlled studies
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Lie Wang, Guangcong Liu, De-Sheng Huang, Guo-Yuan Sui, Yi-Long Yang, and Si-Meng Wang
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Adult ,China ,Chinese adults with cancer ,Cancer Research ,medicine.medical_specialty ,MEDLINE ,Psychological intervention ,Subgroup analysis ,Anxiety ,Ddepression ,Asian People ,Neoplasms ,Genetics ,medicine ,Humans ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Randomized Controlled Trials as Topic ,Depression ,business.industry ,Publication bias ,Middle Aged ,Databases, Bibliographic ,Meta-analysis ,Treatment Outcome ,Oncology ,Strictly standardized mean difference ,medicine.symptom ,business ,Research Article - Abstract
Background Our previous studies found the high prevalence of depression and anxiety among Chinese cancer patients, and many empirical studies have been conducted to evaluate the effects of psychological interventions on depression and anxiety among Chinese cancer patients. This study aimed to conduct a meta-analysis in order to assess the effects of psychological interventions on depression and anxiety in Chinese adults with cancer. Methods The four most comprehensive Chinese academic database- CNKI, Wanfang, Vip and CBM databases-were searched from their inception until January 2014. PubMed and Web of Science (SCIE) were also searched from their inception until January 2014 without language restrictions, and an internet search was used. Randomized controlled studies assessing the effects of psychological interventions on depression and anxiety among Chinese adults with cancer were analyzed. Study selection and appraisal were conducted independently by three authors. The pooled random-effects estimates of standardized mean difference (SMD) and 95% confidence intervals (CI) were calculated. Moderator analysis (meta-regression and subgroup analysis) was used to explore reasons for heterogeneity. Results We retrieved 147 studies (covering 14,039 patients) that reported 253 experimental-control comparisons. The random effects model showed a significant large effect size for depression (SMD = 1.199, p
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- 2014
9. The prevalence of depression and anxiety among Chinese adults with cancer: a systematic review and meta-analysis
- Author
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Xiaoshi Yang, Yang Wang, Jiana Wang, Li Liu, Lie Wang, Yi-Long Yang, and Hui Wu
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Adult ,medicine.medical_specialty ,Cancer Research ,China ,Adolescent ,Anxiety ,Young Adult ,Asian People ,Internal medicine ,Neoplasms ,medicine ,Genetics ,Odds Ratio ,Prevalence ,Humans ,Young adult ,Psychiatry ,Child ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,business.industry ,Depression ,Cancer ,Publication bias ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Oncology ,Meta-analysis ,medicine.symptom ,business ,Publication Bias ,Research Article - Abstract
Background A lot of empirical studies have been conducted to evaluate the prevalence of depression and anxiety among Chinese adults with cancer. We aimed to conduct a meta-analysis in order to evaluate the prevalence and odds ratios of depression and anxiety in Chinese adults with cancer compared with those without. Methods The three most comprehensive computerized Chinese academic databases-CNKI, Wangfang and Vip databases-were systematically screened through September 2012. PubMed and Web of Science (SCIE) were also searched from their inception until September 2012 without language restrictions, and an internet search was also used. Case–control studies assessing the prevalence of depression and anxiety among Chinese adults with cancer were analyzed. Study selection and appraisal were conducted independently by three authors. The non-weighted prevalence, pooled random-effects estimates of odds ratio (OR) and 95% confidence intervals (CI) were all calculated. Results Seventeen eligible studies with a total of 3497 subjects were included. The prevalence of depression and anxiety were significantly higher in adults with cancer compared with those without (Depression: 54.90% vs. 17.50%, OR = 7.85, 95% CI = 5.56-11.07, P = 0.000; Anxiety: 49.69% vs. 18.37%, OR = 6.46, 95% CI = 4.36-9.55, P = 0.000), the same situation was also observed in subgroup of control groups, assessment methods and cancer types. Although no difference of depression was observed in studies utilizing clinical diagnosis compared with self-report, the OR of anxiety in adults with cancer compared with those without was higher in studies utilizing clinical diagnosis (OR = 8.42, 95% CI = 4.83-14.70) than self-reports (OR = 5.83, 95% CI = 3.64-9.34). The ORs of depression and anxiety in cancer patients compared with disease group (Depression: OR = 6.03, 95% CI = 4.23-8.61; Anxiety: OR = 4.40, 95% CI = 3.05-6.36) were lower than in those compared with normal group (Depression: OR = 13.58, 95% CI = 6.26-29.46; Anxiety: OR = 15.47, 95% CI = 10.00-23.95). Conclusions We identified high prevalence rates of depression and anxiety among Chinese adults with cancer. The findings support that the prevalence of depression and anxiety among adults with cancer should receive more attention in Chinese medical settings.
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- 2013
10. The effects of psychological interventions on depression and anxiety among Chinese adults with cancer: a meta-analysis of randomized controlled studies.
- Author
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Yi-Long Yang, Guo-Yuan Sui, Guang-Cong Liu, De-Sheng Huang, Si-Meng Wang, and Lie Wang
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CANCER patients , *MENTAL depression , *ANXIETY disorders , *DISEASE complications , *CHINESE people , *DISEASE prevalence , *MEDICAL databases , *RANDOMIZED controlled trials , *DISEASES - Abstract
Background Our previous studies found the high prevalence of depression and anxiety among Chinese cancer patients, and many empirical studies have been conducted to evaluate the effects of psychological interventions on depression and anxiety among Chinese cancer patients. This study aimed to conduct a meta-analysis in order to assess the effects of psychological interventions on depression and anxiety in Chinese adults with cancer. Methods The four most comprehensive Chinese academic database- CNKI, Wanfang, Vip and CBM databases-were searched from their inception until January 2014. PubMed and Web of Science (SCIE) were also searched from their inception until January 2014 without language restrictions, and an internet search was used. Randomized controlled studies assessing the effects of psychological interventions on depression and anxiety among Chinese adults with cancer were analyzed. Study selection and appraisal were conducted independently by three authors. The pooled random-effects estimates of standardized mean difference (SMD) and 95% confidence intervals (CI) were calculated. Moderator analysis (meta-regression and subgroup analysis) was used to explore reasons for heterogeneity. Results We retrieved 147 studies (covering 14,039 patients) that reported 253 experimental-control comparisons. The random effects model showed a significant large effect size for depression (SMD = 1.199, p < 0.001; 95% CI = 1.095-1.303) and anxiety (SMD = 1.298, p < 0.001; 95% CI = 1.187-1.408). Cumulative meta-analysis indicated that sufficient evidence had accumulated since 2000-2001 to confirm the statistically significant effectiveness of psychological interventions on depression and anxiety in Chinese cancer patients. Moderating effects were found for caner type, patients' selection, intervention format and questionnaires used. In studies that included lung cancer, preselected patients with clear signs of depression/anxiety, adopted individual intervention and used State-Trait Anxiety Inventory (STAI), the effect sizes were larger. Conclusions We concluded that psychological interventions in Chinese cancer patients have large effects on depression and anxiety. The findings support that an adequate system should be set up to provide routine psychological interventions for cancer patients in Chinese medical settings. However, because of some clear limitations (heterogeneity and publication bias), these results should be interpreted with caution. [ABSTRACT FROM AUTHOR]
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- 2014
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- View/download PDF
11. The prevalence of depression and anxiety among Chinese adults with cancer: a systematic review and meta-analysis.
- Author
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Yi-Long Yang, Li Liu, Yang Wang, Hui Wu, Xiao-Shi Yang, Jia-Na Wang, and Lie Wang
- Subjects
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ANXIETY , *CHINESE people , *CANCER patient psychology , *META-analysis , *DISEASES - Abstract
Background: A lot of empirical studies have been conducted to evaluate the prevalence of depression and anxiety among Chinese adults with cancer. We aimed to conduct a meta-analysis in order to evaluate the prevalence and odds ratios of depression and anxiety in Chinese adults with cancer compared with those without. Methods: The three most comprehensive computerized Chinese academic databases-CNKI, Wangfang and Vip databases-were systematically screened through September 2012. PubMed and Web of Science (SCIE) were also searched from their inception until September 2012 without language restrictions, and an internet search was also used. Case-control studies assessing the prevalence of depression and anxiety among Chinese adults with cancer were analyzed. Study selection and appraisal were conducted independently by three authors. The non-weighted prevalence, pooled random-effects estimates of odds ratio (OR) and 95% confidence intervals (CI) were all calculated. Results: Seventeen eligible studies with a total of 3497 subjects were included. The prevalence of depression and anxiety were significantly higher in adults with cancer compared with those without (Depression: 54.90% vs. 17.50%, OR = 7.85, 95% CI = 5.56-11.07, P = 0.000; Anxiety: 49.69% vs. 18.37%, OR = 6.46, 95% CI = 4.36-9.55, P = 0.000), the same situation was also observed in subgroup of control groups, assessment methods and cancer types. Although no difference of depression was observed in studies utilizing clinical diagnosis compared with self-report, the OR of anxiety in adults with cancer compared with those without was higher in studies utilizing clinical diagnosis (OR = 8.42, 95% CI = 4.83-14.70) than self-reports (OR = 5.83, 95% CI = 3.64-9.34). The ORs of depression and anxiety in cancer patients compared with disease group (Depression: OR = 6.03, 95% CI = 4.23-8.61; Anxiety: OR = 4.40, 95% CI = 3.05-6.36) were lower than in those compared with normal group (Depression: OR = 13.58, 95% CI = 6.26-29.46; Anxiety: OR = 15.47, 95% CI = 10.00-23.95). Conclusions: We identified high prevalence rates of depression and anxiety among Chinese adults with cancer. The findings support that the prevalence of depression and anxiety among adults with cancer should receive more attention in Chinese medical settings. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
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