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Start Over Author "Yamamura, Soichiro" Journal bmc cancer
3 results on '"Yamamura, Soichiro"'

3. CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma

Author

Mitsui, Yozo, Chang, Inik, Fukuhara, Shinichiro, Hiraki, Miho, Arichi, Naoko, Yasumoto, Hiroaki, Hirata, Hiroshi, Yamamura, Soichiro, Shahryari, Varahram, Deng, Guoren, Wong, Darryn K, Majid, Shahana, Shiina, Hiroaki, Dahiya, Rajvir, and Tanaka, Yuichiro

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Genetics, Biotechnology, Kidney Disease, Cancer, 2.1 Biological and endogenous factors, Aetiology, Apoptosis, Carcinoma, Renal Cell, Cdc20 Proteins, Cell Line, Tumor, Cell Movement, Cytochrome P-450 CYP1B1, Death-Associated Protein Kinases, Female, Gene Expression Regulation, Neoplastic, Humans, Kidney Neoplasms, Male, Middle Aged, Neoplasm Invasiveness, Up-Regulation, Cytochrome 450 1B1, Renal cell carcinoma, CDC20, DAPK1, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Epidemiology
Abstract

BackgroundCytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has not been well investigated. The aim of the present study was to determine the functional effects of CYP1B1 gene on tumorigenesis in RCC.MethodsExpression of CYP1B1 was determined in RCC cell lines, and tissue microarrays of 96 RCC and 25 normal tissues. To determine the biological significance of CYP1B1 in RCC progression, we silenced the gene in Caki-1 and 769-P cells by RNA interference and performed various functional analyses.ResultsFirst, we confirmed that CYP1B1 protein expression was significantly higher in RCC cell lines compared to normal kidney tissue. This trend was also observed in RCC samples (p

Published
2015

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