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Your search keyword '"Captopril challenge test"' showing total 3 results
Start Over Descriptor "Captopril challenge test" Journal bmc endocrine disorders
3 results on '"Captopril challenge test"'

1. The captopril challenge test for diagnosing primary Aldosteronism in a Chinese population

Author

Ke-ying Zhu, Yan Zhang, Wen-jing Zhang, Hong-yun Li, Wen-huan Feng, Da-long Zhu, and Ping Li

Subjects
Primary aldosteronism, Diagnosis, Captopril challenge test, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Abstract Background The Captopril challenge test (CCT) is an easy-conduct confirmatory test for diagnosing primary aldosteronism (PA). Guidelines show that plasma aldosterone is normally suppressed by captopril (> 30%) in primary hypertension (PH) and in healthy people. It is unclear whether this standard is applicable in Chinese subjects. The aim of the present study was to investigate the post-CCT efficacy of plasma aldosterone concentration (PAC) suppression and determine the post-CCT aldosterone renin activity ratio (ARR) and PAC for PA diagnosis. Methods We recruited 110 consecutive patients with PA, 163 with primary hypertension (PH), and 40 healthy volunteers (NC). The CCT was conducted in all patients. Total sodium intake was estimated from 24-h urinary excretions. ROC curves were used to analyze the efficiency of different CCT diagnostic criteria for diagnosing PA. Results In NC and PH patients, PRA was increased and PAC was decreased post-CCT (P

Published
2019
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3. The captopril challenge test for diagnosing primary Aldosteronism in a Chinese population

Author

Hongyun Li, Yan Zhang, Wenjing Zhang, Keying Zhu, Dalong Zhu, Wenhuan Feng, and Ping Li

Subjects
Adult, Male, medicine.medical_specialty, Captopril, genetic structures, Endocrinology, Diabetes and Metabolism, Urinary system, Urology, 030209 endocrinology & metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Sensitivity and Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Primary aldosteronism, Captopril challenge test, Diabetes mellitus, Diagnosis, Hyperaldosteronism, Renin, medicine, Humans, 030212 general & internal medicine, Aldosterone, Chinese population, lcsh:RC648-665, Receiver operating characteristic, business.industry, Sodium, General Medicine, Middle Aged, medicine.disease, eye diseases, chemistry, ROC Curve, Hypertension, Potassium, Female, sense organs, business, medicine.drug, Research Article
Abstract

Background The Captopril challenge test (CCT) is an easy-conduct confirmatory test for diagnosing primary aldosteronism (PA). Guidelines show that plasma aldosterone is normally suppressed by captopril (> 30%) in primary hypertension (PH) and in healthy people. It is unclear whether this standard is applicable in Chinese subjects. The aim of the present study was to investigate the post-CCT efficacy of plasma aldosterone concentration (PAC) suppression and determine the post-CCT aldosterone renin activity ratio (ARR) and PAC for PA diagnosis. Methods We recruited 110 consecutive patients with PA, 163 with primary hypertension (PH), and 40 healthy volunteers (NC). The CCT was conducted in all patients. Total sodium intake was estimated from 24-h urinary excretions. ROC curves were used to analyze the efficiency of different CCT diagnostic criteria for diagnosing PA. Results In NC and PH patients, PRA was increased and PAC was decreased post-CCT (P

Published
2019

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