1. Analyzing the influence of gastric intestinal metaplasia on gastric ulcer healing in Helicobacter pylori-infected patients without atrophic gastritis.
- Author
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Li-Wei Chen, Liang-Che Chang, Chung-Ching Hua, Bor-Jen Hsieh, Shuo-Wei Chen, Rong-Nan Chien, Chen, Li-Wei, Chang, Liang-Che, Hua, Chung-Ching, Hsieh, Bor-Jen, Chen, Shuo-Wei, and Chien, Rong-Nan
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GASTRIC diseases , *PEPTIC ulcer , *ULCER treatment , *METAPLASIA , *HELICOBACTER pylori infections , *ETIOLOGY of diseases , *DIAGNOSIS , *ULCERS , *THERAPEUTICS , *DISEASE risk factors , *ANTIBIOTICS , *PROTON pump inhibitors , *GUT microbiome , *COMPARATIVE studies , *HELICOBACTER diseases , *HELICOBACTER pylori , *INTESTINES , *RESEARCH methodology , *MEDICAL cooperation , *MULTIVARIATE analysis , *PSYCHOLOGICAL tests , *RESEARCH , *STOMACH , *LOGISTIC regression analysis , *EVALUATION research , *PAIN measurement , *RETROSPECTIVE studies , *DISEASE complications - Abstract
Background: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with IM and those without IM.Methods: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period from March 2005 to January 2011. The inclusion criteria were: 1) endoscopic findings of GU and biopsy histological examination plus rapid urease test indicating H. pylori infection; 2) gastric IM adjacent to a GU but with no atrophic gastritis changes; 3) patients receiving H. pylori eradication triple therapy and 8 weeks of maintenance therapy with a proton pump inhibitor; and 4) patients receiving follow-up endoscopy within the 3rd and the 4th months after treatment.Results: In total, 327 patients with GU and H. pylori infection (136 with IM and 191 without IM) were included. Patients with IM had a higher GU healing rate than those without IM (91.9% vs. 84.3%, P = 0.040). Multivariate logistical regression analysis revealed that failure of H. pylori eradication (Odds = 4.013, 95% CI: 1.840-8.951, P < 0.001) and gastric IM (Odds = 0.369, 95% CI: 0.168-0.812, P = 0.013) were the predictors of non-healing GU following treatment.Conclusions: Patient with gastric IM change may have a higher GU healing rate than those without gastric IM. However, successful H. pylori eradication is a more important factor for GU healing than gastric IM. [ABSTRACT FROM AUTHOR]- Published
- 2017
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