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Your search keyword '"Mwacharo, Joram M"' showing total 3 results
Start Over Author "Mwacharo, Joram M" Journal bmc genomics
3 results on '"Mwacharo, Joram M"'

3. Genome-wide analysis reveals the extent of EAV-HP integration in domestic chicken

Author

Wragg, David, Mason, Andrew S, Yu, Le, Kuo, Richard, Lawal, Raman A, Desta, Takele Taye, Mwacharo, Joram M, Cho, Chang-Yeon, Kemp, Stephen, Burt, David W, Hanotte, Olivier, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Nottingham, UK (UON), Roslin Institute, University of Edinburgh, GAIC Co Ltd, Partenaires INRAE, International Center for Agricultural Research in the Dry Areas [Syrie] (ICARDA), and National Institute of Animal Science

Subjects
Retrovirus, Symbiosis, Adaptation, Immunogenetics, Genetics, NGS, Gallus, animal structures, Retrovirus, Genome, retrovirus, symbiosis, adaptation, immunogenetic, genetic, ngs, gallus, [SDV]Life Sciences [q-bio], Virus Integration, Gallus, Poultry, Evolution, Molecular, Retroviridae, NGS, Animals, Domestic, Immunogenetics, Genetics, Animals, [INFO]Computer Science [cs], Adaptation, Symbiosis, Chickens, Phylogeny, Biotechnology, Research Article
Abstract

Background EAV-HP is an ancient retrovirus pre-dating Gallus speciation, which continues to circulate in modern chicken populations, and led to the emergence of avian leukosis virus subgroup J causing significant economic losses to the poultry industry. We mapped EAV-HP integration sites in Ethiopian village chickens, a Silkie, Taiwan Country chicken, red junglefowl Gallus gallus and several inbred experimental lines using whole-genome sequence data. Results An average of 75.22 ± 9.52 integration sites per bird were identified, which collectively group into 279 intervals of which 5 % are common to 90 % of the genomes analysed and are suggestive of pre-domestication integration events. More than a third of intervals are specific to individual genomes, supporting active circulation of EAV-HP in modern chickens. Interval density is correlated with chromosome length (P

Published
2015

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