16 results on '"Han, Yang"'
Search Results
2. Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China
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Jia Xie, Xiao-Han Yang, Si-Qi Hu, Wen-Li Zhan, Chang-Bin Zhang, Hong Liu, Hong-Yu Zhao, Hui-Ying Chai, Ke-Yi Chen, Qian-Yi Du, Pan Liu, Ai-Hua Yin, and Ming-Yong Luo
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Enterovirus ,Coxsackievirus ,Co-circulation ,Hand, foot, and mouth disease ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Hand, foot, and mouth disease (HFMD) is a common infectious disease occurring in children under 5 years of age worldwide, and Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CVA-16) are identified as the predominant pathogens. In recent years, Coxsackievirus A6 (CVA-6) and Coxsackievirus A10 (CVA-10) have played more and more important role in a series of HFMD outbreaks. This study aimed to understand the epidemic characteristics associated with HFMD outbreak in Guangzhou, 2018. Methods The clinical and laboratory data of 1220 enterovirus-associated HFMD patients in 2018 were analysed in this study. Molecular diagnostic methods were performed to identify its serotypes. Phylogenetic analyses were depicted based on the complete VP1 gene. Results There were 21 enterovirus serotypes detected in Guangzhou in 2018. Three serotypes of enterovirus, CVA-6 (364/1220, 29.8%), CVA-10 (305/1220, 25.0%), and CVA-16 (397/1220, 32.5%), were identified as the causative pathogens and accounted for 87.3% among all 1220 HFMD patients. In different seasons, CVA-6 was the predominant pathogen of HFMD during autumn, and CVA-10 as well as CVA-16 were more prevalent in summer. Patients infected by CVA-6, CVA-10 or CVA-16 showed similar clinical features and laboratory characteristics, and the ratios of severe HFMD were 5.8, 5.9, and 1.5% in the three serotypes. Phylogenetic analyses of VP1 sequences showed that the CVA-6, CVA-10, and CVA-16 sequences belonged to the sub-genogroup E2, genogroup E, and genogroup B1, respectively. Conclusions CVA-6, CVA-10, and CVA-16 were the predominant and co-circulated serotypes in Guangzhou China, 2018, which should be the new target for prevention and control of HFMD. Our findings provide useful information for diagnosis, treatment, and prevention of HFMD.
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- 2020
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3. Pharmacodynamics of efavirenz 400 mg in treatment-naïve Chinese HIV-infected patients in a prospective cohort study
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Xu, Ling, Peng, Wenxiu, Song, Xiaojing, Li, Yanling, Han, Yang, Zhu, Ting, Fu, Qiang, Du, Xiaoli, Cao, Wei, and Li, Taisheng
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- 2021
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4. Correction to: Pharmacodynamics of efavirenz 400 mg in treatment-naïve Chinese HIV-infected patients in a prospective cohort study
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Xu, Ling, Peng, Wenxiu, Song, Xiaojing, Li, Yanling, Han, Yang, Zhu, Ting, Fu, Qiang, Du, Xiaoli, Cao, Wei, and Li, Taisheng
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- 2021
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5. Therapeutic prediction of HIV-1 DNA decay: a multicenter longitudinal cohort study
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Yue, Yongsong, Li, Yijia, Cui, Yizhi, Wang, Nidan, Huang, Yunda, Cao, Wei, Han, Yang, Zhu, Ting, Lyu, Wei, Xie, Jing, Song, Xiaojing, Li, Yanling, Wang, Tong, Zhu, Tuofu, and Li, Taisheng
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- 2021
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6. Whole blood as an alternative to peripheral blood mononuclear cell for detection of total HIV-1 DNA
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Lin, Ling, Yue, Yong-Song, Wang, Ni-Dan, Wei, Lei-Yan, Han, Yang, Song, Xiao-Jing, Qiu, Zhi-Feng, Cao, Wei, and Li, Tai-Sheng
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- 2020
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7. Leukotoxin and pyrogenic toxin Superantigen gene backgrounds in bloodstream and wound Staphylococcus aureus isolates from eastern region of China
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Chunyan He, Su Xu, Huanqiang Zhao, Fupin Hu, Xiaogang Xu, Shu Jin, Han Yang, Fang Gong, and Qingzhong Liu
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Staphylococcus aureus ,Leukocidin gene ,Pyrogenic toxin superantigen gene ,lukED expression ,Genetic characteristic ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The bicomponent leukotoxins and the pyrogenic toxin superantigens (PTSAgs) are important virulence factors of Staphylococcus aureus. It is necessary to survey the prevalence and expression of these toxin-encoding genes for understanding the possible pathogenic capacity of S. aureus to cause disease. Methods Five leukotoxin genes and thirteen PTSAg determinants were detected for 177 S. aureus isolates from blood (n = 88) and wound (n = 89) infections by Polymerase Chain Reaction (PCR). The expression of leukotoxin ED (lukED) was determined by quantitative real-time PCR (qRT-PCR). The genetic backgrounds of isolates were analyzed by Staphylococcal Cassette Chromosome mec (SCCmec) typing (for methicillin-resistant S. aureus isolates), Pulsed-Field Gel Electrophoresis (PFGE), accessory gene regulator (agr) typing and Multilocus Sequence Typing (MLST, for representative isolates based on PFGE type) methods. Results 99.4% (176/177) isolates contained at least one of leukotoxin genes. Among them, 94.9% (168/177), 81.4% (144/177) and 67.8% (120/177) isolates harbored hlgBC, lukED and lukAB, respectively. Compared to leukotoxin genes, there was a relatively lower overall prevalence of PTSAg genes [99.4% versus 72.9% (129/177), P
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- 2018
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8. HIV-1 CRF01_AE subtype and HIV-1 DNA level among patients with chronic HIV-1 infection: a correlation study
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Lyu, Tingxia, Yue, Yongsong, Hsieh, Evelyn, Han, Yang, Zhu, Ting, Song, Xiaojing, Cao, Wei, Lyu, Wei, Wang, Jianhua, and Li, Taisheng
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- 2020
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9. The effects of antiretroviral therapy initiation time on HIV reservoir size in Chinese chronically HIV infected patients: a prospective, multi-site cohort study
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Luo, Ling, Wang, Nidan, Yue, Yongsong, Han, Yang, Lv, Wei, Liu, Zhengyin, Qiu, Zhifeng, Lu, Hongzhou, Tang, Xiaoping, Zhang, Tong, Zhao, Min, He, Yun, Shenghua, He, Wang, Min, Li, Yongzhen, Huang, Shaobiao, Li, Yong, Liu, Jing, Tuofu, Zhu, Routy, Jean-Pierre, and Li, Taisheng
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- 2019
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10. A higher CD4/CD8 ratio correlates with an ultralow cell-associated HIV-1 DNA level in chronically infected patients on antiretroviral therapy: a case control study.
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Yongsong Yue, Nidan Wang, Yang Han, Ting Zhu, Jing Xie, Zhifeng Qiu, Xiaojing Song, Yanling Li, Routy, Jean-Pierre, Jianhua Wang, Taisheng Li, Yue, Yongsong, Wang, Nidan, Han, Yang, Zhu, Ting, Xie, Jing, Qiu, Zhifeng, Song, Xiaojing, Li, Yanling, and Wang, Jianhua
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CD4 antigen ,CD8 antigen ,ANTIRETROVIRAL agents ,HIV ,MONONUCLEAR leukocytes ,DIAGNOSIS of HIV infections ,CHRONIC diseases ,HIV infections ,MULTIVARIATE analysis ,POLYMERASE chain reaction ,RESEARCH funding ,RNA ,T cells ,VIRAL load ,CASE-control method - Abstract
Background: The HIV-1 DNA reservoir is an important marker that reflects viro-immunological status and can be affected by multiple viral or cellular factors. Determining the potential factors associated with the size of the HIV-1 DNA reservoir benefits the surveillance of disease progression and antiretroviral treatments.Methods: We conducted a case control study to explore the factors that may affect the level of HIV-1 DNA. The level of HIV-1 total DNA in peripheral blood at 5 time points was quantified by quantitative PCR. Chronically HIV-1-infected patients whose cell-associated HIV-1 DNA levels were below the detection limit after receiving antiretroviral therapy (ART) for 96 weeks were identified (group 1), and patients who still had detectable levels of cell-associated HIV-1 DNA after ATR treatment were used as the control (group 2).Results: Twenty-one patients with ultralow levels of cell-associated HIV-1 DNA [<20 copies/106 peripheral blood mononuclear cells (PBMCs)] presented with a lower CD8+ T-cell count (average: 511 ± 191 versus 715 ± 256 cells/μL, p = 0.013) and a higher CD4/CD8 ratio (average: 1.04 ± 0.37 versus 0.72 ± 0.32, respectively, p = 0.002) at week 96. In the multivariate analysis, patients with a higher CD4/CD8 ratio at week 96 were more likely to have levels of HIV-1 DNA below the detection limit (per 0.1 increase, OR = 1.29, 95% CI, 1.05-1.59, p = 0.017).Conclusion: After matching baseline HIV-1 DNA levels, a higher CD4/CD8 ratio at week 96 was the only factor associated with an ultralow level of HIV-1 DNA. The CD4/CD8 ratio can be used as an easy biomarker to help monitor patients on ART who will be selected to participate in eradication studies. [ABSTRACT FROM AUTHOR]- Published
- 2017
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11. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease.
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Fuping Guo, Hsieh, Evelyn, Wei Lv, Yang Han, Jing Xie, Yanling Li, Xiaojing Song, Taisheng Li, Guo, Fuping, Lv, Wei, Han, Yang, Xie, Jing, Li, Yanling, Song, Xiaojing, and Li, Taisheng
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CARDIOVASCULAR disease related mortality ,HIV-positive persons ,MORTALITY ,CARDIOVASCULAR diseases risk factors ,DYSLIPIDEMIA ,HYPERTENSION ,HIV infection complications ,ANTI-HIV agents ,HYPERTENSION epidemiology ,HIV infection epidemiology ,OBESITY complications ,CARDIOVASCULAR diseases ,COMPARATIVE studies ,DIABETES ,HYPERLIPIDEMIA ,RESEARCH methodology ,MEDICAL cooperation ,OBESITY ,RESEARCH ,SMOKING ,EVALUATION research ,CROSS-sectional method ,RETROSPECTIVE studies ,DISEASE complications - Abstract
Background: Cardiovascular disease (CVD) is an important cause of mortality among HIV-infected patients, however little is known about the burden of CVD among this population in Asia. We sought to quantify prevalence of CVD risk factors, 10-year CVD risk, and patterns of CVD risk factor treatment in a group of individuals with HIV in China.Methods: We retrospectively analyzed baseline data from treatment-naïve HIV-infected adults enrolled in two multicenter clinical trials in China. Data regarding CVD risk factors such as smoking, hypertension, diabetes, dyslipidemia and obesity were assessed. The Framingham Risk Score (FRS) and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) risk scores were calculated to estimate 10-year CVD risk. The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score was used to identify individuals meeting criteria for lipid-lowering therapy.Results: In total, 973 patients were included in the analysis. Mean age was 36.0 ± 10.2 years and 74.2% were men. The most common CVD risk factors were dyslipidemia (51.7%) and smoking (23.7%). Prevalence of hypertension, diabetes and obesity were 8.4%, 4.6% and 1.0%, respectively. Over 65% of patients had at least one CVD risk factor. The prevalence of 10-year risk of CVD ≥10% was 4.5% based upon FRS and was 3.3% based upon D:A:D risk score. Few patients with dyslipidemia, hypertension or diabetes were on treatment.Conclusions: CVD risk factors are common but under-treated among Chinese treatment-naïve individuals with HIV. Future interventions should focus on training HIV providers to appropriately recognize and manage CVD risk factors during routine clinical assessments. [ABSTRACT FROM AUTHOR]- Published
- 2017
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12. Clinical and epidemiological features of the 2014 large-scale dengue outbreak in Guangzhou city, China.
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Yong Ping Lin, Yasha Luo, Yuan Chen, Lamers, Mart Matthias, Qiang Zhou, Xiao Han Yang, Sanyal, Sumana, Ka Pun Mok, Chris, Zhong Min Liu, Lin, Yong Ping, Luo, Yasha, Chen, Yuan, Zhou, Qiang, Yang, Xiao Han, Mok, Chris Ka Pun, and Liu, Zhong Min
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DENGUE viruses ,PREVENTION of epidemics ,SEROTYPES ,BLOOD serum analysis ,DENGUE ,DISEASE outbreaks ,BIOLOGICAL evolution ,FLAVIVIRUSES ,HOSPITAL care ,POLYMERASE chain reaction ,URBAN health ,REVERSE transcriptase polymerase chain reaction ,DIAGNOSIS - Abstract
Background: Dengue virus is transmitted by mosquito around the tropical and sub-tropical regions. There was a large-scale dengue epidemic in Guangdong province, China during 2014 and around fifty thousands dengue fever cases, including six deaths, have been reported. In this study, we aimed to understand the clinical characteristics of hospitalized patients with laboratory-confirmed dengue virus (DENV) infection and determined the origin of the virus from the outbreak.Methods: We have summarized the data from 138 hospitalized patients who were laboratory confirmed for dengue infection in Guangzhou city. Patients were classified as either non-severe dengue fever or severe dengue fever according to the guidelines from the WHO. Viral serotypes were determined by real time RT-PCR. Genetic sequences of the envelope and non-structural genes were amplified and analyzed from the serum samples of eleven patients.Results: Co-circulation of dengue serotype 1 and 2 were identified from the outbreak. Patients infected by serotype 1 or 2 showed similar clinical features. Patients with severe dengue fever showed prolonged hospitalization and significant impairment of organ functions. Four samples from serotype 1 and five samples from serotype 2 were closely related respectively and clustered with Guangzhou isolates from previous years. The remaining isolates of serotype 1 were related to viruses found in Malaysia, India, Bangladesh and Singapore.Conclusion: The phylogenetic grouping of Guangdong isolates suggests that dengue is no longer an imported disease in China. Analysis of the isolates obtained in this study together with the size of the outbreak are suggestive of endemic circulation in Guangdong province. [ABSTRACT FROM AUTHOR]- Published
- 2016
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13. Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted protease inhibitor-based regimen on renal function in HIV-infected individuals: a prospective, multicenter study.
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Cao, Ying, Han, Yang, Xie, Jing, Cui, Qu, Zhang, Lixia, Li, Yijia, Li, Yanling, Song, Xiaojing, Zhu, Ting, and Li, Taisheng
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Background: The aim of this study was to investigate the impact of a tenofovir disoproxil fumarate (TDF) plus ritonavir-boosted protease inhibitor (PI/r) regimen on renal function in Chinese HIV-infected patients.Methods: Seventy-five HIV-1 infected patients failing first-line antiretroviral therapy (ART) comprised the TDF+PI/r group. Seventy-five HIV-1 infected patients matched for gender, age, and renal function made up the control. All subjects completed follow-up visits over 48 weeks. CD4 cell count, plasma HIV-1 viral load, and urine protein level were assessed at the trial start (baseline, week 0) and at week 48. The serum creatinine and estimated glomerular filtration rate (eGFR) were monitored at each follow-up point. Change in eGFR from baseline to week 48 was also compared.Results: Compared to control, the TDF+PI/r group exhibited higher levels of serum creatinine (79 vs. 69.7 μmol/L, P<0.001) and a lower rate of eGFR (93.0 vs. 101.6 ml/min/1.73 m², P=0.009) at the end of week 48. Patients treated with TDF+PI/r showed greater decline in eGFR than control (-8.8 vs. 6.4 ml/min/1.73 m², P<0.001). Compared to baseline renal function of the control group, the TDF+PI/r group exhibited a greater median decline in eGFR at the end of week 48 (P<0.001).Conclusions: We found that a TDF+PI/r based ART regimen resulted in greater renal function decline over 48 weeks. Therefore, renal function should be monitored especially when TDF is used in combination with PI/r.Trial Registration: ClinicalTrials.gov identifier: NCT00872417. [ABSTRACT FROM AUTHOR]- Published
- 2013
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14. A higher CD4/CD8 ratio correlates with an ultralow cell-associated HIV-1 DNA level in chronically infected patients on antiretroviral therapy: a case control study.
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Yue Y, Wang N, Han Y, Zhu T, Xie J, Qiu Z, Song X, Li Y, Routy JP, Wang J, and Li T
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- Adult, Anti-Retroviral Agents therapeutic use, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes cytology, CD8-Positive T-Lymphocytes cytology, Case-Control Studies, Chronic Disease, Female, HIV Infections drug therapy, HIV Infections virology, HIV-1 isolation & purification, Humans, Leukocytes, Mononuclear cytology, Limit of Detection, Male, Multivariate Analysis, Real-Time Polymerase Chain Reaction, Viral Load, HIV Infections diagnosis, HIV-1 genetics, RNA, Viral blood
- Abstract
Background: The HIV-1 DNA reservoir is an important marker that reflects viro-immunological status and can be affected by multiple viral or cellular factors. Determining the potential factors associated with the size of the HIV-1 DNA reservoir benefits the surveillance of disease progression and antiretroviral treatments., Methods: We conducted a case control study to explore the factors that may affect the level of HIV-1 DNA. The level of HIV-1 total DNA in peripheral blood at 5 time points was quantified by quantitative PCR. Chronically HIV-1-infected patients whose cell-associated HIV-1 DNA levels were below the detection limit after receiving antiretroviral therapy (ART) for 96 weeks were identified (group 1), and patients who still had detectable levels of cell-associated HIV-1 DNA after ATR treatment were used as the control (group 2)., Results: Twenty-one patients with ultralow levels of cell-associated HIV-1 DNA [<20 copies/10
6 peripheral blood mononuclear cells (PBMCs)] presented with a lower CD8+ T-cell count (average: 511 ± 191 versus 715 ± 256 cells/μL, p = 0.013) and a higher CD4/CD8 ratio (average: 1.04 ± 0.37 versus 0.72 ± 0.32, respectively, p = 0.002) at week 96. In the multivariate analysis, patients with a higher CD4/CD8 ratio at week 96 were more likely to have levels of HIV-1 DNA below the detection limit (per 0.1 increase, OR = 1.29, 95% CI, 1.05-1.59, p = 0.017)., Conclusion: After matching baseline HIV-1 DNA levels, a higher CD4/CD8 ratio at week 96 was the only factor associated with an ultralow level of HIV-1 DNA. The CD4/CD8 ratio can be used as an easy biomarker to help monitor patients on ART who will be selected to participate in eradication studies.- Published
- 2017
- Full Text
- View/download PDF
15. Cardiovascular disease risk among Chinese antiretroviral-naïve adults with advanced HIV disease.
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Guo F, Hsieh E, Lv W, Han Y, Xie J, Li Y, Song X, and Li T
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- Adult, Anti-HIV Agents therapeutic use, China epidemiology, Cross-Sectional Studies, Diabetes Mellitus epidemiology, Dyslipidemias epidemiology, Dyslipidemias etiology, Female, HIV Infections epidemiology, Humans, Hypertension complications, Hypertension drug therapy, Hypertension epidemiology, Male, Middle Aged, Obesity complications, Obesity epidemiology, Retrospective Studies, Risk Factors, Smoking epidemiology, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, HIV Infections complications
- Abstract
Background: Cardiovascular disease (CVD) is an important cause of mortality among HIV-infected patients, however little is known about the burden of CVD among this population in Asia. We sought to quantify prevalence of CVD risk factors, 10-year CVD risk, and patterns of CVD risk factor treatment in a group of individuals with HIV in China., Methods: We retrospectively analyzed baseline data from treatment-naïve HIV-infected adults enrolled in two multicenter clinical trials in China. Data regarding CVD risk factors such as smoking, hypertension, diabetes, dyslipidemia and obesity were assessed. The Framingham Risk Score (FRS) and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) risk scores were calculated to estimate 10-year CVD risk. The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score was used to identify individuals meeting criteria for lipid-lowering therapy., Results: In total, 973 patients were included in the analysis. Mean age was 36.0 ± 10.2 years and 74.2% were men. The most common CVD risk factors were dyslipidemia (51.7%) and smoking (23.7%). Prevalence of hypertension, diabetes and obesity were 8.4%, 4.6% and 1.0%, respectively. Over 65% of patients had at least one CVD risk factor. The prevalence of 10-year risk of CVD ≥10% was 4.5% based upon FRS and was 3.3% based upon D:A:D risk score. Few patients with dyslipidemia, hypertension or diabetes were on treatment., Conclusions: CVD risk factors are common but under-treated among Chinese treatment-naïve individuals with HIV. Future interventions should focus on training HIV providers to appropriately recognize and manage CVD risk factors during routine clinical assessments.
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- 2017
- Full Text
- View/download PDF
16. The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004.
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Li H, Chang S, Han Y, Zhuang D, Li L, Liu Y, Liu S, Bao Z, Zhang W, Song H, Li T, and Li J
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- Adolescent, Adult, Aged, China epidemiology, Female, HIV Infections epidemiology, HIV-1 genetics, Humans, Male, Middle Aged, Young Adult, Anti-HIV Agents therapeutic use, Drug Resistance, Viral drug effects, HIV Infections virology, HIV-1 drug effects
- Abstract
Background: The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic., Methods: We conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database., Results: Of 521 participants, 478 samples were amplified and sequenced successfully. HIV Transmitted drug resistance prevalence in China was determined to be 6.7 %. We did not find significant differences in the TDR rate by demographic characteristics. No significant time trend in the prevalence of overall TDR was observed (p > 0.05)., Conclusions: We identified an intermediate prevalence of transmitted drug resistance (TDR), exhibiting a stable time trend. These findings enhance our understanding of HIV-1 drug resistance prevalence and time trend, and provide some guidelines for the comprehensive public health strategy of TDR prevention.
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- 2016
- Full Text
- View/download PDF
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