1. Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy - a case report.
- Author
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Nguyen Thi Cam Huong, Altibi, Ahmed M. A., Nguyen My Hoa, Le Anh Tuan, Salman, Samar, Morsy, Sara, Nguyen Thi Bich Lien, Nguyen Thanh Truong, Nguyen Thi Hoang Mai, Pham Thi Le Hoa, Nguyen Ba Thang, Van The Trung, Huong, Nguyen Thi Cam, Hoa, Nguyen My, Tuan, Le Anh, Lien, Nguyen Thi Bich, Truong, Nguyen Thanh, Mai, Nguyen Thi Hoang, Hoa, Pham Thi Le, and Thang, Nguyen Ba
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CRYPTOCOCCOSIS , *CRYPTOCOCCUS neoformans , *HIV-positive persons , *MYASTHENIA gravis , *THYMOMA , *IMMUNOSUPPRESSIVE agents - Abstract
Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly rare and usually signifies a marked immunodeficiency. Cryptococcosis in association with myasthenia gravis or thymoma has been previously documented in only very few cases in the literature.Case Presentation: We reported a complicated case of severe cutaneous cryptococcosis in a 39-year-old Vietnamese male patient with myasthenia gravis on long-term immunosuppressive therapy. The patient presented with a five month history of recurrent and progressive skin lesions that later on progressed into cryptococcal meningitis.Conclusion: Through this case, we aimed to emphasize the importance of including cutaneous cryptococcosis in the differential diagnosis of cutaneous lesions in patients on chronic immunosuppressive therapy. The cutaneous manifestations of cryptococcosis can be the first clue for a disseminated disease, which makes early recognition crucial and life-saving. [ABSTRACT FROM AUTHOR]- Published
- 2017
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