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2 results on '"Shengxi Liu"'

1. Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

Author

Kui Li, Caiyong Yang, Zicheng Jiang, Shengxi Liu, Jun Liu, Chuanqi Fan, Tao Li, and Xuemin Dong

Subjects
Tuberculosis, T-SPOT.TB, IGRA, Diagnosis, Risk factors, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Previous qualitative studies suggested that the false negative rate of the T cell spot test for tuberculosis infection (T-SPOT.TB) is associated with many risk factors in tuberculosis patients. However, more precise quantitative studies are lacking. The purpose of this study was to investigate the factors affecting quantified spot-forming cells (SFCs) to early secreted antigenic target 6 kDa (ESAT-6) or culture filtrate protein 10 kDa (CFP-10) in patients with active tuberculosis. Methods We retrospectively analyzed the data of 360 patients who met the inclusion criteria. Using the SFCs to ESAT-6 or CFP-10 levels as dependent variables, variables with statistical significance in the univariate analysis were subjected to optimal scaling regression analysis. The combination of ESAT-6 and CFP-10 (i.e., T-SPOT.TB) was analyzed by the exact logistic regression model. Results The results showed that the SFCs to ESAT-6 regression model had statistical significance (P

Published
2019
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2. Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

Author

Caiyong Yang, Tao Li, Jun Liu, Zicheng Jiang, Shengxi Liu, Xuemin Dong, Kui Li, and Chuanqi Fan

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Tuberculosis, T cell, T-Lymphocytes, 030106 microbiology, Logistic regression, Gastroenterology, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Antigen, Internal medicine, Statistical significance, Diagnosis, medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, T-SPOT.TB, Aged, Retrospective Studies, Antigens, Bacterial, Univariate analysis, IGRA, business.industry, Platelet Distribution Width, Regression analysis, Mycobacterium tuberculosis, Middle Aged, Active tuberculosis, bacterial infections and mycoses, medicine.disease, medicine.anatomical_structure, Infectious Diseases, Risk factors, Immunology, Optimal scaling, Female, business, CD8, Research Article
Abstract

Background Previous qualitative studies suggested that the false negative rate of the T cell spot test for tuberculosis infection (T-SPOT.TB) is associated with many risk factors in tuberculosis patients. However, more precise quantitative studies are lacking. The purpose of this study was to investigate the factors affecting quantified spot-forming cells (SFCs) to early secreted antigenic target 6 kDa (ESAT-6) or culture filtrate protein 10 kDa (CFP-10) in patients with active tuberculosis. Methods We retrospectively analyzed the data of 360 patients who met the inclusion criteria. Using the SFCs to ESAT-6 or CFP-10 levels as dependent variables, variables with statistical significance in the univariate analysis were subjected to optimal scaling regression analysis. The combination of ESAT-6 and CFP-10 (i.e., T-SPOT.TB) was analyzed by the exact logistic regression model. Results The results showed that the SFCs to ESAT-6 regression model had statistical significance (P

Published
2019

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