1. Continuous infusion versus intermittent infusion of vancomycin in critically ill patients undergoing continuous venovenous hemofiltration: a prospective interventional study
- Author
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Jinhui Xu, Lufen Duan, Jiahui Li, Fang Chen, Xiaowen Xu, Jian Lu, Zhiwei Zhuang, Yifei Cao, Yunlong Yuan, Xin Liu, Jiantong Sun, Qin Zhou, Lu Shi, and Lian Tang
- Subjects
Vancomycin ,Continuous venovenous hemofiltration ,Continuous infusion ,Intermittent infusion ,Prospective interventional study ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background A prospective interventional study comparing outcomes in critically ill patients receiving intermittent infusion (II) or continuous infusion (CI) of vancomycin during continuous venovenous hemofiltration (CVVH) is lacking. The objective of this study was to compare the pharmacokinetic/pharmacodynamics (PK/PD) target attainment, therapeutic efficacy and safety among critically ill patients who received CI or II of vancomycin in a prospective interventional trial and to explore the correlations of effluent flow rate (EFR) with PK/PD indices. Methods This prospective interventional study was conducted in two independent intensive care units (ICUs) from February 2021 to January 2022. Patients in one ICU were assigned to receive CI (intervention group) of vancomycin, whereas patients in the other ICU were assigned to receive II regimen (control group). The primary outcome was to compare the PK/PD target attainment, including target concentration and target area under the curve over 24 h to minimum inhibitory concentration (AUC24/MIC). Results Overall target attainment of PK/PD indices was higher with CI compared with II, irrespective of target concentration (78.7% vs. 40.5%; P
- Published
- 2022
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