1. CD209 in inflammatory bowel disease: a case-control study in the Spanish population
- Author
-
Carlos Taxonera, Juan Luis Mendoza, Elena Urcelay, María Gómez-García, Javier Martín, Javier Oliver, Miguel A. López-Nevot, Concepción Núñez, Alfonso Martínez, Luis Miguel Gómez, Emilio G. de la Concha, [Núñez,C, G de la Concha,E, Urcelay,E, Martínez,A] Servicio de Inmunología Clínica, Hospital Clínico San Carlos, Madrid, Spain.[Oliver,J, Gómez,LM, Martín,J] Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain.[Mendoza,JL, Taxonera,C] Unidad de Enfermedad Inflamatoria Intestinal, Hospital Clínico San Carlos, Madrid, Spain. [Gómez-García,M] Unidad de Enfermedad Inflamatoria Intestinal, Hospital Virgen de las Nieves, Granada, Spain. [López-Nevot,MA] Servicio de Inmunología, Hospital Virgen de las Nieves, Granada, Spain., and This work was supported by grants SAF2003-08522 and SAF2006-00398. Concepción Núñez and Alfonso Martínez have a FIS contract (CA06/0163 and CP04/00175, respectively) and Elena Urcelay works for the 'Fundación para la Investigación Biomédica-Hospital Clínico San Carlos'.
- Subjects
Male ,Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease [Medical Subject Headings] ,España ,Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Disease ,Inflammatory bowel disease ,Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Cell Adhesion Molecules [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Mediana Edad ,Crohn Disease ,Gene Frequency ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Statistical Distributions::Chi-Square Distribution [Medical Subject Headings] ,Genetics(clinical) ,Masculino ,Colitis Ulcerosa ,Genetics (clinical) ,Distribución de Chi-Cuadrado ,Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Antígenos HLA-DR ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings] ,integumentary system ,Adulto ,Femenino ,Lectinas Tipo C ,Estudios de Casos y Controles ,Inflammatory Bowel Diseases ,Middle Aged ,Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease [Medical Subject Headings] ,Ulcerative colitis ,Humanos ,Marcadores Genéticos ,Female ,Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings] ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface [Medical Subject Headings] ,Research Article ,Adult ,Genetic Markers ,lcsh:Internal medicine ,Genotype ,lcsh:QH426-470 ,Frecuencia de los Genes ,Receptores de Superficie Celular ,Predisposición Genética a la Enfermedad ,Check Tags::Male [Medical Subject Headings] ,Receptors, Cell Surface ,Biology ,Enfermedades Intestinales ,Polymorphism, Single Nucleotide ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens [Medical Subject Headings] ,Chemicals and Drugs::Biological Factors::Biological Markers::Genetic Markers [Medical Subject Headings] ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Lectins, C-Type ,Enfermedad de Crohn ,lcsh:RC31-1245 ,Gene ,Chi-Square Distribution ,Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings] ,Case-control study ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lectins::Lectins, C-Type [Medical Subject Headings] ,HLA-DR Antigens ,medicine.disease ,Spanish population ,Intestinal Diseases ,lcsh:Genetics ,Check Tags::Female [Medical Subject Headings] ,Spain ,Case-Control Studies ,Immunology ,Etiology ,Colitis, Ulcerative ,Moléculas de Adhesión Celular ,Polimorfismo de Nucleótido Simple ,Phenomena and Processes::Genetic Phenomena::Gene Frequency [Medical Subject Headings] ,Cell Adhesion Molecules ,Genotipo - Abstract
This article is available from: http://www.biomedcentral.com/1471-2350/8/75, [Background] The etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors. Although some genes are already known, the genetics underlying these diseases is complex and new candidates are continuously emerging. The CD209 gene is located in a region linked previously to IBD and a CD209 functional polymorphism (rs4804803) has been associated to other inflammatory conditions. Our aim was to study the potential involvement of this CD209 variant in IBD susceptibility., [Methods] We performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the CD209 single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using χ2 tests., [Results] No association between CD209 and UC or CD was observed initially. However, stratification of UC patients by HLA-DR3 status, a strong protective allele, showed that carriage of the CD209_G allele could increase susceptibility in the subgroup of HLA-DR3-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04–3.02, vs. controls)., [Conclusion] A functional variant in the CD209 gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary., This work was supported by grants SAF2003-08522 and SAF2006-00398. Concepción Núñez and Alfonso Martínez have a FIS contract (CA06/0163 and CP04/00175, respectively) and Elena Urcelay works for the "Fundación para la Investigación Biomédica-Hospital Clínico San Carlos".
- Published
- 2007