1. Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level
- Author
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Yu-Chen Sun, Ming-Sheng Teng, Hsien-Hsun Chang, Jeng-Feng Lin, Yu-Lin Ko, Lung-An Hsu, Semon Wu, and Hsuan-Pu Chen
- Subjects
Adult ,Male ,Linkage disequilibrium ,lcsh:Internal medicine ,lcsh:QH426-470 ,Interaction ,Matrix metalloproteinase 9 ,Taiwan ,Biology ,MMP9 ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Asian People ,Genotype ,SE-selectin ,Genetics ,Haplotype ,Humans ,Genetics(clinical) ,Polymorphism ,lcsh:RC31-1245 ,Genetics (clinical) ,Genetic association study ,E-selectin ,Plasma levels ,Middle Aged ,Human genetics ,body regions ,lcsh:Genetics ,Haplotypes ,Linear Models ,Regression Analysis ,Female ,Research Article - Abstract
Background E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals. Methods Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed. Results SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511). Conclusion SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.
- Published
- 2012