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Your search keyword '"Prieto, James M"' showing total 1 results
Start Over Author "Prieto, James M" Journal bmc medical genomics
1 results on '"Prieto, James M"'

1. Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease.

Author

Bickler, Stephen W, Cauvi, David M, Fisch, Kathleen M, Prieto, James M, Sykes, Alicia G, Thangarajah, Hariharan, Lazar, David A, Ignacio, Romeo C, Gerstmann, Dale R, Ryan, Allen F, Bickler, Philip E, and De Maio, Antonio

Subjects
Fibroblasts, Dermis, Humans, Peptidyl-Dipeptidase A, Receptors, Virus, Gene Expression Profiling, Age Factors, Gene Expression Regulation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Receptors, Pattern Recognition, Young Adult, RNA-Seq, COVID-19, SARS-CoV-2, Aging, Pattern recognition receptors, Skin fibroblasts, Toll-like receptor 4, Human Genome, Vaccine Related, Biodefense, Infectious Diseases, Lung, Clinical Research, Pneumonia, Prevention, Emerging Infectious Diseases, Genetics, Good Health and Well Being, Medical Biochemistry and Metabolomics, Oncology and Carcinogenesis, Genetics & Heredity
Abstract

BackgroundOlder aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes.MethodsUsing a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2.ResultsExtremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins.ConclusionsAssessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels.

Published
2021

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