23 results on '"Li, Wei"'
Search Results
2. A preliminary study of proximal realignment combination surgery in the treatment of adolescent habitual patellar dislocation
- Author
-
Li, Wei, Zhang, De-Bao, Xu, Sheng-Ming, Bi, Huang-Yi, and Gu, Gui-Shan
- Published
- 2023
- Full Text
- View/download PDF
3. Posterior osteosynthesis with a new self-designed lateral mass screw-plate system for unstable atlas burst fractures
- Author
-
Yang, Kun, Niu, He-gang, Tao, Hui, Liu, Chang, Cao, Yun, Li, Wei, Zhang, Jing-jing, Shen, Cai-liang, and Zhang, Yin-shun
- Published
- 2023
- Full Text
- View/download PDF
4. Randomized controlled trial of all-inside and standard single-bundle anterior cruciate ligament reconstruction with functional, MRI-based graft maturity and patient-reported outcome measures
- Author
-
Lin, Rubing, Zhong, Qiuwen, Wu, Xiao, Cui, Lei, Huang, Rong, Deng, Qianhua, Zuo, Jianwei, Jiang, Changqing, and Li, Wei
- Published
- 2022
- Full Text
- View/download PDF
5. Fat infiltration of paraspinal muscles as an independent risk for bone nonunion after posterior lumbar interbody fusion
- Author
-
Han, Gengyu, Zou, Da, Liu, Zexiang, Zhang, Bo, Gong, Chunjie, Zhou, Siyu, Li, Wei, Sun, Zhuoran, and Li, Weishi
- Published
- 2022
- Full Text
- View/download PDF
6. Paraspinal muscle characteristics on MRI in degenerative lumbar spine with normal bone density, osteopenia and osteoporosis: a case-control study
- Author
-
Han, Gengyu, Zou, Da, Liu, Zexiang, Zhou, Siyu, Li, Wei, Gong, Chunjie, Sun, Zhuoran, and Li, Weishi
- Published
- 2022
- Full Text
- View/download PDF
7. Closed reduction and percutaneous pinning vs open reduction and internal fixation in pediatric lateral condylar humerus fractures displaced by > 4 mm: an observational cross-sectional study
- Author
-
Xie, Li-wei, Deng, Zhi-qiang, Zhao, Ren-huan, Wang, Juan, Liu, Xin, Zhou, Ying, and Zhang, Hui
- Published
- 2021
- Full Text
- View/download PDF
8. Treatment of pediatric supracondylar humerus fractures accompanied with pink pulseless hands
- Author
-
Xie, Li-wei, Wang, Juan, and Deng, Zhi-qiang
- Published
- 2021
- Full Text
- View/download PDF
9. Treatment of pediatric lateral condylar humerus fractures with closed reduction and percutaneous pinning
- Author
-
Xie, Li-wei, Wang, Juan, Deng, Zhi-qiang, Zhao, Ren-huan, Chen, Wei, Kang, Chi, Ye, Jia-jun, Liu, Xin, Zhou, Ying, and Shen, Hai
- Published
- 2020
- Full Text
- View/download PDF
10. Lumbar plain radiograph is not reliable to identify lumbosacral transitional vertebra types according to Castellvi classification principle
- Author
-
Hou, Lisheng, Bai, Xuedong, Li, Haifeng, Gao, Tianjun, Li, Wei, Wen, Tianyong, He, Qing, Ruan, Dike, Shi, Lijing, and Bing, Wei
- Published
- 2020
- Full Text
- View/download PDF
11. Phospholipase C signaling activated by parathyroid hormone mediates the rapid osteoclastogenesis in the fracture healing of orchiectomized mice
- Author
-
Li, Wei, Yuan, Liang, Tong, Guojun, He, Youhua, Meng, Yue, Hao, Song, Chen, Jianting, Guo, Jun, Bringhurst, Richard, and Yang, Dehong
- Published
- 2018
- Full Text
- View/download PDF
12. Is hydroxychloroquine effective in treating primary Sjogren's syndrome: a systematic review and meta-analysis.
- Author
-
Shi-Qin Wang, Li-Wei Zhang, Pan Wei, Hong Hua, Wang, Shi-Qin, Zhang, Li-Wei, Wei, Pan, and Hua, Hong
- Subjects
- *
SJOGREN'S syndrome , *QUINOLINE , *TREATMENT effectiveness , *DRUG efficacy , *META-analysis , *THERAPEUTICS - Abstract
Background: To systematically review and assess the efficacy and safety of hydroxychloroquine (HCQ) for treating primary Sjogren's syndrome (pSS).Methods: Five electronic databases (Pubmed, EMBASE, Web of science, Ovid, Cochrane Library) were searched for randomized controlled trials and retrospective or prospective studies published in English that reported the effect of HCQ on pSS. The subjective symptoms (sicca symptoms, fatigue and pain) and the objective indexes (erythrocyte sedimentation rate and Schirmer test) were assessed as main outcome measures. A meta-analysis and descriptive study on the efficacy and safety of HCQ were conducted. The estimate of the effect of HCQ treatment was expressed as a proportion together with 95% confidence interval, and plotted on a forest plot.Results: Four trials with totals of 215 SS patients, including two randomized controlled trials, one double blind crossover trial and one retrospective open-label study, were analyzed in this review. For dry mouth and dry eyes, the effectiveness of HCQ treatment was essentially the same as placebo treatment. For fatigue, the effectiveness of HCQ was lower than placebo. The efficacy of HCQ in treating pain associated with pSS was superior to that of the placebo. There was no significant difference between HCQ-treated groups and controls in terms of Schirmer test results, but HCQ could reduce the erythrocyte sedimentation rate compare with placebo. A descriptive safety assessment showed that gastrointestinal adverse effects were the most common adverse effects associated with HCQ.Conclusions: This systematic review showed that there is no significant difference between HCQ and placebo in the treatment of dry mouth and dry eye in pSS. Well-designed, randomized, controlled trials are needed to provide higher-quality evidence to confirm our findings, and future studies should focus on some other index or extraglandular measures, such as cutaneous manifestations, to further explore the therapeutic effect of HCQ in pSS. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
13. Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients.
- Author
-
Qing-yao Zuo, Hong Wang, Wei Li, Xiao-hui Niu, Yan-hong Huang, Jia Chen, Yu-hua You, Bao-yue Liu, Ai-min Cui, Wei Deng, Zuo, Qing-Yao, Wang, Hong, Li, Wei, Niu, Xiao-Hui, Huang, Yan-Hong, Chen, Jia, You, Yu-Hua, Liu, Bao-Yue, Cui, Ai-Min, and Deng, Wei
- Subjects
HEALTH outcome assessment ,OSTEOMALACIA ,VITAMIN D deficiency ,RETROSPECTIVE studies ,HYPOPHOSPHATEMIA ,THERAPEUTICS ,LONGITUDINAL method ,PARANEOPLASTIC syndromes ,PHOSPHATES ,SOFT tissue tumors ,TREATMENT effectiveness ,CONNECTIVE tissue tumors - Abstract
Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. Nonspecific symptoms make the diagnosis elusive. In addition, locating the responsible tumor(s) is challenging. The aim of this study was to investigate the clinical management and outcomes of TIO.Methods: The clinical features, diagnostic procedures, treatment, and outcomes of 12 patients were reviewed retrospectively.Results: The cohort comprised six men and six women (mean age 45.5 ± 9.9 years, range 23-61 years). The mean duration of disease was 3.7 ± 2.6 years. All patients manifested progressive bone pain, muscle weakness, and/or difficulty walking. Serum phosphorus concentrations were low in all patients (mean 0.42 ± 0.12 mmol/L). Technetium-99m octreotide scintigraphy was performed in 11 patients and showed lesions in the right distal femur, left femoral head, and right tibial plateau, respectively, in three patients. Magnetic resonance imaging (MRI) was negative for lesions in one patient. Two patients underwent biopsies that showed negative histopathology. Two patients, at 2 years and 8 months, respectively, after having negative technetium-99m octreotide studies, underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography (CT), which revealed lesions in the sacrum and soft tissue of the left palm, respectively. One tumor was detected by CT and MRI. Overall, lesion sites were the head (two patients, 16.7%), thoracic and lumbar region (two, 16.7%), pelvis (three, 25%), lower limbs (four, 33.3%), and upper limbs (one, 8.3%). All patients underwent surgery, and histopathology showed phosphaturic mesenchymal tumors in each. Postoperatively, serum phosphorus concentrations normalized within 2-7 days in 11 patients. With follow-ups of 1-41 months, surgery was effective in 10 patients. One patient developed local recurrence and another had metastases.Conclusions: Locating tumors responsible for tumor-induced osteomalacia is often challenging. Although complete tumor resection confers a good prognosis in most patients, surveillance for recurrence and metastasis is necessary. Before surgery or when surgery is not indicated, oral phosphate can alleviate symptoms and metabolic imbalance. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
14. Hip fracture risk assessment: artificial neural network outperforms conditional logistic regression in an age- and sex-matched case control study
- Author
-
Li-Wei Hung, Jinn Lin, Jiann-Shing Shieh, Wo-Jan Tseng, and Maysam F. Abbod
- Subjects
Artificial neural network ,Male ,medicine.medical_specialty ,Multivariate analysis ,Wilcoxon signed-rank test ,Taiwan ,Standard score ,Effect Modifier, Epidemiologic ,Risk Assessment ,Hip fracture ,Sex Factors ,Rheumatology ,Statistics ,Conditional logistic regression ,Discrimination ,medicine ,Humans ,Orthopedics and Sports Medicine ,Aged ,Aged, 80 and over ,Likelihood Functions ,business.industry ,Hip Fractures ,Univariate ,Age Factors ,Odds ratio ,Middle Aged ,medicine.disease ,Surgery ,Logistic Models ,Case-Control Studies ,Calibration ,Population study ,Female ,Neural Networks, Computer ,Risk assessment ,business ,Osteoporotic Fractures ,Research Article - Abstract
Background Osteoporotic hip fractures with a significant morbidity and excess mortality among the elderly have imposed huge health and economic burdens on societies worldwide. In this age- and sex-matched case control study, we examined the risk factors of hip fractures and assessed the fracture risk by conditional logistic regression (CLR) and ensemble artificial neural network (ANN). The performances of these two classifiers were compared. Methods The study population consisted of 217 pairs (149 women and 68 men) of fractures and controls with an age older than 60 years. All the participants were interviewed with the same standardized questionnaire including questions on 66 risk factors in 12 categories. Univariate CLR analysis was initially conducted to examine the unadjusted odds ratio of all potential risk factors. The significant risk factors were then tested by multivariate analyses. For fracture risk assessment, the participants were randomly divided into modeling and testing datasets for 10-fold cross validation analyses. The predicting models built by CLR and ANN in modeling datasets were applied to testing datasets for generalization study. The performances, including discrimination and calibration, were compared with non-parametric Wilcoxon tests. Results In univariate CLR analyses, 16 variables achieved significant level, and six of them remained significant in multivariate analyses, including low T score, low BMI, low MMSE score, milk intake, walking difficulty, and significant fall at home. For discrimination, ANN outperformed CLR in both 16- and 6-variable analyses in modeling and testing datasets (p? Conclusions The risk factors of hip fracture are more personal than environmental. With adequate model construction, ANN may outperform CLR in both discrimination and calibration. ANN seems to have not been developed to its full potential and efforts should be made to improve its performance.
- Published
- 2013
15. High short-term and long-term excess mortality in geriatric patients after hip fracture: a prospective cohort study in Taiwan.
- Author
-
Li-Wei Hung, Wo-Jan Tseng, Guey-Shiun Huang, and Jinn Lin
- Subjects
- *
MORTALITY , *GERIATRIC psychiatry , *TOTAL hip replacement , *POPULATION - Abstract
Background Hip fracture has a high mortality rate, but the actual level of long-term excess mortality and its impact on population-wide mortality remains controversial. The present prospective study investigated short- and long-term excess mortality after hip fractures with adjustment of other risk factors. We calculated the population attributable risk proportion (PARP) to assess the impact of each risk factor on excess mortality. Methods We recruited 217 elders with hip fractures and 215 age- and sex-matched patients without fractures from the geriatric department of the same hospital. The mean follow-up time was 46.1 months (range: 35 to 57 months). We recorded data on 55 covariates, including baseline details about health, function, and bone mineral density. We used the multivariate Cox proportional hazards model to analyze hazard ratios (HRs) of short-term (<12 months followup) and long-term (⩾12 months follow-up) excess mortality for each covariate and calculated their PARP. Results Patients with hip fractures had a higher short-term mortality than non-fractured patients, and the long-term excess mortality associated with hip fracture remained high. The significant risk factors for short-term mortality were hip fracture, comorbidities, and lower (below cutoff) Mini Mental State Examination score with HRs of 2.4, 2.3, and 2.3, respectively. Their PARPs were 44.7%, 38.1%, and 34.3%, respectively. The significant risk factors for long-term mortality were hip fracture (HR: 2.7; PARP: 48.0%), lower T-score (HR: 3.3; PARP: 36.2%), lower body mass index (HR: 2.5; PARP: 42.8%), comorbidities (HR: 2.1; PARP: 34.8%), difficulty in activities of daily living (HR: 1.9; PARP: 31.8%), and smoking (HR: 2.5; PARP: 19.2%). Conclusions After comprehensive adjustment, hip fracture was a significant risk factor and contributed the most to long-term as well as short-term excess mortality. Its adequate prevention and treatment should be targeted. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
16. Hip fracture risk assessment: artificial neural network outperforms conditional logistic regression in an age- and sex-matched case control study.
- Author
-
Wo-Jan Tseng, Li-Wei Hung, Jiann-Shing Shieh, Abbod, Maysam F., and Jinn Lin
- Subjects
- *
HIP fractures , *ARTIFICIAL neural networks , *LOGISTIC regression analysis , *MORTALITY , *QUESTIONNAIRES , *WILCOXON signed-rank test , *INJURY risk factors - Abstract
Background: Osteoporotic hip fractures with a significant morbidity and excess mortality among the elderly have imposed huge health and economic burdens on societies worldwide. In this age- and sex-matched case control study, we examined the risk factors of hip fractures and assessed the fracture risk by conditional logistic regression (CLR) and ensemble artificial neural network (ANN). The performances of these two classifiers were compared. Methods: The study population consisted of 217 pairs (149 women and 68 men) of fractures and controls with an age older than 60 years. All the participants were interviewed with the same standardized questionnaire including questions on 66 risk factors in 12 categories. Univariate CLR analysis was initially conducted to examine the unadjusted odds ratio of all potential risk factors. The significant risk factors were then tested by multivariate analyses. For fracture risk assessment, the participants were randomly divided into modeling and testing datasets for 10-fold cross validation analyses. The predicting models built by CLR and ANN in modeling datasets were applied to testing datasets for generalization study. The performances, including discrimination and calibration, were compared with non-parametric Wilcoxon tests. Results: In univariate CLR analyses, 16 variables achieved significant level, and six of them remained significant in multivariate analyses, including low T score, low BMI, low MMSE score, milk intake, walking difficulty, and significant fall at home. For discrimination, ANN outperformed CLR in both 16- and 6-variable analyses in modeling and testing datasets (p < 0.005). For calibration, ANN outperformed CLR only in 16-variable analyses in modeling and testing datasets (p = 0.013 and 0.047, respectively). Conclusions: The risk factors of hip fracture are more personal than environmental. With adequate model construction, ANN may outperform CLR in both discrimination and calibration. ANN seems to have not been developed to its full potential and efforts should be made to improve its performance. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
17. High short-term and long-term excess mortality in geriatric patients after hip fracture: a prospective cohort study in Taiwan.
- Author
-
Hung, Li-Wei, Tseng, Wo-Jan, Huang, Guey-Shiun, and Lin, Jinn
- Abstract
Background: Hip fracture has a high mortality rate, but the actual level of long-term excess mortality and its impact on population-wide mortality remains controversial. The present prospective study investigated short- and long-term excess mortality after hip fractures with adjustment of other risk factors. We calculated the population attributable risk proportion (PARP) to assess the impact of each risk factor on excess mortality.Methods: We recruited 217 elders with hip fractures and 215 age- and sex-matched patients without fractures from the geriatric department of the same hospital. The mean follow-up time was 46.1 months (range: 35 to 57 months). We recorded data on 55 covariates, including baseline details about health, function, and bone mineral density. We used the multivariate Cox proportional hazards model to analyze hazard ratios (HRs) of short-term (<12 months follow-up) and long-term (≧ 2 months follow-up) excess mortality for each covariate and calculated their PARP.Results: Patients with hip fractures had a higher short-term mortality than non-fractured patients, and the long-term excess mortality associated with hip fracture remained high. The significant risk factors for short-term mortality were hip fracture, comorbidities, and lower (below cutoff) Mini Mental State Examination score with HRs of 2.4, 2.3, and 2.3, respectively. Their PARPs were 44.7%, 38.1%, and 34.3%, respectively. The significant risk factors for long-term mortality were hip fracture (HR: 2.7; PARP: 48.0%), lower T-score (HR: 3.3; PARP: 36.2%), lower body mass index (HR: 2.5; PARP: 42.8%), comorbidities (HR: 2.1; PARP: 34.8%), difficulty in activities of daily living (HR: 1.9; PARP: 31.8%), and smoking (HR: 2.5; PARP: 19.2%).Conclusions: After comprehensive adjustment, hip fracture was a significant risk factor and contributed the most to long-term as well as short-term excess mortality. Its adequate prevention and treatment should be targeted. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
18. The shift of segmental contribution ratio in patients with herniated disc during cervical lateral bending.
- Author
-
Lan, Haw-Chang H, Chen, Han-Yu, Kuo, Li-Chieh, You, Jia-Yuan, Li, Wei-Chun, and Wu, Shyi-Kuen
- Abstract
Background: Abnormal intervertebral movements of spine have been reported to be associated with trauma and pathological conditions. The importance of objective spinal motion imaging assessment in the frontal plane was frequently underestimated. The clinical evaluation of the segmental motion contribution could be useful for detecting the motion pattern of individual vertebrae. Therefore the purpose of this study was to investigate the shift of segmental contribution ratio in patients with herniated disc during cervical lateral bending to provide additional insights to cervical biomechanics.Methods: A total of 92 subjects (46 healthy adult subjects and 46 disc-herniated patients) were enrolled in this case-control study. The motion images during cervical lateral bending movements were digitized using a precise image protocol to analyze the intervertebral motion and contribution.Results: Our results showed that the intervertebral angulation during cervical lateral bending for the C2/3 to C6/7 segments were 7.66°±2.37°, 8.37°±2.11°, 8.91°±3.22°, 7.19°±2.29°, 6.31°±2.11°, respectively for the healthy subjects. For the patients with herniated disc, the intervertebral angulation for the C2/3 to C6/7 segments were 6.87°±1.67°, 7.83°±1.79°, 7.73°±2.71°, 5.13°±2.05°, 4.80°±1.93°, respectively. There were significant angulation and translational differences between healthy subjects and the patients with herniated disc in the C5/6 and C6/7 segments (P=0.001-0.029). The segmental contributions of the individual vertebral segments were further analyzed. There was a significant increase in segmental contribution ratio of C3/4 (P=0.048), while a significant decrease in contribution ratio of C5/6 (P=0.037) was observed in the patients with herniated disc. Our results indicated that the segmental contribution shifted toward the middle cervical spine in the patients with herniated disc.Conclusions: The segmental contributions of cervical spine during lateral bending movement were first described based on the validated radiographic protocol. The detection of the shift of segmental contribution ratio could be helpful for the diagnosis the motion abnormality resulted from the disc or, facet pathologies, and arthritic changes of cervical spine. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
19. Hip fracture risk assessment: artificial neural network outperforms conditional logistic regression in an age- and sex-matched case control study.
- Author
-
Tseng, Wo-Jan, Hung, Li-Wei, Shieh, Jiann-Shing, Abbod, Maysam F, and Lin, Jinn
- Abstract
Background: Osteoporotic hip fractures with a significant morbidity and excess mortality among the elderly have imposed huge health and economic burdens on societies worldwide. In this age- and sex-matched case control study, we examined the risk factors of hip fractures and assessed the fracture risk by conditional logistic regression (CLR) and ensemble artificial neural network (ANN). The performances of these two classifiers were compared.Methods: The study population consisted of 217 pairs (149 women and 68 men) of fractures and controls with an age older than 60 years. All the participants were interviewed with the same standardized questionnaire including questions on 66 risk factors in 12 categories. Univariate CLR analysis was initially conducted to examine the unadjusted odds ratio of all potential risk factors. The significant risk factors were then tested by multivariate analyses. For fracture risk assessment, the participants were randomly divided into modeling and testing datasets for 10-fold cross validation analyses. The predicting models built by CLR and ANN in modeling datasets were applied to testing datasets for generalization study. The performances, including discrimination and calibration, were compared with non-parametric Wilcoxon tests.Results: In univariate CLR analyses, 16 variables achieved significant level, and six of them remained significant in multivariate analyses, including low T score, low BMI, low MMSE score, milk intake, walking difficulty, and significant fall at home. For discrimination, ANN outperformed CLR in both 16- and 6-variable analyses in modeling and testing datasets (p?0.005). For calibration, ANN outperformed CLR only in 16-variable analyses in modeling and testing datasets (p?=?0.013 and 0.047, respectively).Conclusions: The risk factors of hip fracture are more personal than environmental. With adequate model construction, ANN may outperform CLR in both discrimination and calibration. ANN seems to have not been developed to its full potential and efforts should be made to improve its performance. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
20. Treatment and outcomes of tumor-induced osteomalacia associated with phosphaturic mesenchymal tumors: retrospective review of 12 patients.
- Author
-
Zuo QY, Wang H, Li W, Niu XH, Huang YH, Chen J, You YH, Liu BY, Cui AM, and Deng W
- Subjects
- Adult, Cohort Studies, Female, Follow-Up Studies, Humans, Hypophosphatemia blood, Hypophosphatemia surgery, Male, Middle Aged, Neoplasms, Connective Tissue blood, Neoplasms, Connective Tissue surgery, Osteomalacia blood, Osteomalacia diagnostic imaging, Osteomalacia surgery, Paraneoplastic Syndromes blood, Paraneoplastic Syndromes surgery, Phosphates blood, Retrospective Studies, Soft Tissue Neoplasms blood, Soft Tissue Neoplasms surgery, Treatment Outcome, Hypophosphatemia diagnostic imaging, Neoplasms, Connective Tissue diagnostic imaging, Paraneoplastic Syndromes diagnostic imaging, Soft Tissue Neoplasms diagnostic imaging
- Abstract
Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. Nonspecific symptoms make the diagnosis elusive. In addition, locating the responsible tumor(s) is challenging. The aim of this study was to investigate the clinical management and outcomes of TIO., Methods: The clinical features, diagnostic procedures, treatment, and outcomes of 12 patients were reviewed retrospectively., Results: The cohort comprised six men and six women (mean age 45.5 ± 9.9 years, range 23-61 years). The mean duration of disease was 3.7 ± 2.6 years. All patients manifested progressive bone pain, muscle weakness, and/or difficulty walking. Serum phosphorus concentrations were low in all patients (mean 0.42 ± 0.12 mmol/L). Technetium-99m octreotide scintigraphy was performed in 11 patients and showed lesions in the right distal femur, left femoral head, and right tibial plateau, respectively, in three patients. Magnetic resonance imaging (MRI) was negative for lesions in one patient. Two patients underwent biopsies that showed negative histopathology. Two patients, at 2 years and 8 months, respectively, after having negative technetium-99m octreotide studies, underwent
18 F-fluorodeoxyglucose positron emission tomography/computed tomography (CT), which revealed lesions in the sacrum and soft tissue of the left palm, respectively. One tumor was detected by CT and MRI. Overall, lesion sites were the head (two patients, 16.7%), thoracic and lumbar region (two, 16.7%), pelvis (three, 25%), lower limbs (four, 33.3%), and upper limbs (one, 8.3%). All patients underwent surgery, and histopathology showed phosphaturic mesenchymal tumors in each. Postoperatively, serum phosphorus concentrations normalized within 2-7 days in 11 patients. With follow-ups of 1-41 months, surgery was effective in 10 patients. One patient developed local recurrence and another had metastases., Conclusions: Locating tumors responsible for tumor-induced osteomalacia is often challenging. Although complete tumor resection confers a good prognosis in most patients, surveillance for recurrence and metastasis is necessary. Before surgery or when surgery is not indicated, oral phosphate can alleviate symptoms and metabolic imbalance.- Published
- 2017
- Full Text
- View/download PDF
21. Is hydroxychloroquine effective in treating primary Sjogren's syndrome: a systematic review and meta-analysis.
- Author
-
Wang SQ, Zhang LW, Wei P, and Hua H
- Subjects
- Humans, Prospective Studies, Randomized Controlled Trials as Topic methods, Retrospective Studies, Sjogren's Syndrome epidemiology, Treatment Outcome, Antirheumatic Agents therapeutic use, Hydroxychloroquine therapeutic use, Sjogren's Syndrome diagnosis, Sjogren's Syndrome drug therapy
- Abstract
Background: To systematically review and assess the efficacy and safety of hydroxychloroquine (HCQ) for treating primary Sjogren's syndrome (pSS)., Methods: Five electronic databases (Pubmed, EMBASE, Web of science, Ovid, Cochrane Library) were searched for randomized controlled trials and retrospective or prospective studies published in English that reported the effect of HCQ on pSS. The subjective symptoms (sicca symptoms, fatigue and pain) and the objective indexes (erythrocyte sedimentation rate and Schirmer test) were assessed as main outcome measures. A meta-analysis and descriptive study on the efficacy and safety of HCQ were conducted. The estimate of the effect of HCQ treatment was expressed as a proportion together with 95% confidence interval, and plotted on a forest plot., Results: Four trials with totals of 215 SS patients, including two randomized controlled trials, one double blind crossover trial and one retrospective open-label study, were analyzed in this review. For dry mouth and dry eyes, the effectiveness of HCQ treatment was essentially the same as placebo treatment. For fatigue, the effectiveness of HCQ was lower than placebo. The efficacy of HCQ in treating pain associated with pSS was superior to that of the placebo. There was no significant difference between HCQ-treated groups and controls in terms of Schirmer test results, but HCQ could reduce the erythrocyte sedimentation rate compare with placebo. A descriptive safety assessment showed that gastrointestinal adverse effects were the most common adverse effects associated with HCQ., Conclusions: This systematic review showed that there is no significant difference between HCQ and placebo in the treatment of dry mouth and dry eye in pSS. Well-designed, randomized, controlled trials are needed to provide higher-quality evidence to confirm our findings, and future studies should focus on some other index or extraglandular measures, such as cutaneous manifestations, to further explore the therapeutic effect of HCQ in pSS.
- Published
- 2017
- Full Text
- View/download PDF
22. Quantitative T2 relaxation time and magnetic transfer ratio predict endplate biochemical content of intervertebral disc degeneration in a canine model.
- Author
-
Chen C, Jia Z, Han Z, Gu T, Li W, Li H, Tang Y, Wu J, Wang D, He Q, and Ruan D
- Subjects
- Animals, Dogs, Forecasting, Intervertebral Disc Degeneration metabolism, Pilot Projects, Disease Models, Animal, Intervertebral Disc Degeneration pathology, Lumbar Vertebrae chemistry, Lumbar Vertebrae pathology, Magnetic Resonance Imaging methods
- Abstract
Background: Direct measurement of disc biochemical content is impossible in vivo. Therefore, magnetic resonance imaging (MRI) is used to evaluate disc health. Unfortunately, current clinical imaging techniques do not adequately assess degeneration, especially in the early stage of cartilage endplate, and subchondral bone zone (CEPZ). Therefore, this study aimed to investigate the sensitivity of quantitative MRI methods, namely T2 relaxation time and Magnetic Transfer Ratio (MTR), to identify early disc degeneration, especially for the CEPZ, using an experimental canine model of intervertebral disc injury and to investigate their sensitivity in depicting biochemically and histologically controlled degenerative changes in the disc., Methods: Sixteen juvenile dogs underwent iatrogenic annular disruption via stab incisions. The animals underwent repeated 3.0 T MR imaging, and were sacrificed 4, 8, and 12 weeks post-operatively. A continuous rectangle drawing method was used to select regions of interest for the intervertebral disc from the cephalic to caudal CEPZ including the vertebrae, nucleus pulposus (NP) and annulus fibrosus (AF), which resembled pixel measurement for imaging analysis. Presence of degenerative changes was controlled by biochemical and histological analyses. The correlations between histological score, biochemical content, and quantitative MRI signal intensities were also analyzed., Results: Both T2 relaxation time and MTR values changed for CEPZ, NP, and AF tissues within 12 weeks. T2 relaxation time values decreased significantly in the NP, AF, and CEPZ separately at pre-operation, 4, 8, and 12 weeks when compared each time (P < 0.05). MTR values showed no significant differences for the CEPZ between 8 and 4 weeks or 12 weeks, or compared to pre-operative values; there were significant differences for the AF. Biochemical and histological analysis showed changes consistent with quantitative MRI signal intensities for early stage degeneration., Conclusions: Early traumatic or degenerative changes are detectable with both T2 and MTR. T2 changes were more sensitive to the differences in disc status, especially for the CEPZ. Since T2 and MTR reflect different disc properties, performing both imaging under the same conditions would be helpful in the evaluation of disc degeneration. The continuous rectangle drawing can be a sensitive method to detect the changes of CEPZ.
- Published
- 2015
- Full Text
- View/download PDF
23. Mechanical pain sensitivity of deep tissues in children--possible development of myofascial trigger points in children.
- Author
-
Han TI, Hong CZ, Kuo FC, Hsieh YL, Chou LW, and Kao MJ
- Subjects
- Age Factors, Child, Child, Preschool, Chronic Pain diagnosis, Female, Humans, Male, Musculoskeletal Diseases diagnosis, Musculoskeletal Diseases physiopathology, Myofascial Pain Syndromes diagnosis, Pain Measurement methods, Aging physiology, Chronic Pain physiopathology, Mechanoreceptors physiology, Myofascial Pain Syndromes physiopathology, Pain Threshold physiology
- Abstract
Background: It is still unclear when latent myofascial trigger points (MTrPs) develop during early life. This study is designed to investigate the mechanical pain sensitivity of deep tissues in children in order to see the possible timing of the development of latent MTrPs and attachment trigger points (A-TrPs) in school children., Methods: Five hundreds and five healthy school children (age 4- 11 years) were investigated. A pressure algometer was used to measure the pressure pain threshold (PPT) at three different sites in the brachioradialis muscle: the lateral epicondyle at elbow (site A, assumed to be the A-TrP site), the mid-point of the muscle belly (site B, assumed to be the MTrP site), and the muscle-tendon junction as a control site (site C)., Results: The results showed that, for all children in this study, the mean PPT values was significantly lower (p < 0.05) at the assumed A-TrP site (site A) than at the other two sites, and was significantly lower (p < 0.05) at the assumed MTrP site (site B) than at the control site (site C). These findings are consistent if the data is analyzed for different genders, different dominant sides, and different activity levels., Conclusions: It is concluded that a child had increased sensitivity at the tendon attachment site and the muscle belly (endplate zone) after age of 4 years. Therefore, it is likely that a child may develop an A-Trp and a latent MTrP at the brachioradialis muscle after the age of 4 years. The changes in sensitivity, or the development for these trigger points, may not be related to the activity level of children aged 7-11 years. Further investigation is still required to identify the exact timing of the initial occurrence of a-Trps and latent MTrPs.
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.