1. Computed tomography derived cervical fat-free muscle fraction as an imaging-based outcome marker in patients with acute ischemic stroke: a pilot study
- Author
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Narine Mesropyan, Louisa Khorsandian, Anton Faron, Alois M. Sprinkart, Franziska Dorn, Daniel Paech, Alexander Isaak, Daniel Kuetting, Claus C. Pieper, Alexander Radbruch, Ulrike I. Attenberger, Jens Reimann, Felix J. Bode, Cornelia Kornblum, and Julian A. Luetkens
- Subjects
Acute ischemic stroke ,Computed tomography ,Muscle quality ,Fat-free muscle fraction ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Outcome assessment in stroke patients is essential for evidence-based stroke care planning. Computed tomography (CT) is the mainstay of diagnosis in acute stroke. This study aimed to investigate whether CT-derived cervical fat-free muscle fraction (FFMF) as a biomarker of muscle quality is associated with outcome parameters after acute ischemic stroke. Methods In this retrospective study, 66 patients (mean age: 76 ± 13 years, 30 female) with acute ischemic stroke in the anterior circulation who underwent CT, including CT-angiography, and endovascular mechanical thrombectomy of the middle cerebral artery between August 2016 and January 2020 were identified. Based on densitometric thresholds, cervical paraspinal muscles covered on CT-angiography were separated into areas of fatty and lean muscle and FFMF was calculated. The study cohort was binarized based on median FFMF (cutoff value:
- Published
- 2023
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